Abstract：
PURPOSE:Functional bowel outcome in patients with anorectal malformation often is poor. For fecal incontinence resulting from sphincter dysfunction, biofeedback (BFB) training appears to be effective. The aim of study was to investigate the bowel function in incontinent children treated for ARM, using a clinical score, a manometric and pelvic magnetic resonance evaluation, in order to establish predictive parameters of response after BFB. METHODS:25 children (median age of 6.5 years) with true fecal incontinence were evaluated by clinical score, anorectal manometry and magnetic resonance imaging (MRI). According to these evaluations patients were divided in 4 groups: group 1 (favorables manometry and MRI); group 2 (favorable manometry and unfavorable MRI); group 3 (unfavorable manometry and favorable MRI); group 4 (unfavorables manometry and MRI). All groups started a cycle of BFB and six months after end of BFB, were reevaluated by clinical score and manometry. RESULTS:The overall response to BFB was excellent in 44%, discrete in 40% and poor in 16%; a better response was found in groups 1 and 2 than groups 3 and 4. The differences between groups before BFB proportionally correlated with values after BFB; a correlation with genitourinary and spinal anomalies was found. CONCLUSIONS:Our results showed that BFB is an effective for fecal incontinence when the assessment pretreatment (functional and morphologic) is favorable; the manometry can evaluate the potential sphincterial recovery after BFB with a further prognostic benefit if correlated to morphologic evaluation with MRI.
journal_name
J Pediatr Surgjournal_title
Journal of pediatric surgeryauthors
Caruso AM,Catalano P,Li Voti G,Salerno S,Casuccio A,Di Pace MR,Cimador Mdoi
10.1016/j.jpedsurg.2015.03.068subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1648-52issue
10eissn
0022-3468issn
1531-5037pii
S0022-3468(15)00316-4journal_volume
50pub_type
临床试验,杂志文章abstract：BACKGROUND/PURPOSE:Since the discovery of the cystic fibrosis transmembrane regulator (CFTR) gene, cystic fibrosis has been an attractive target for gene therapy. Postnatal gene transfer in the respiratory epithelium has been difficult and particularly inefficient in the submucosal gland cells, the target cells for CFT...
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journal_title：Journal of pediatric surgery
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journal_title：Journal of pediatric surgery
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journal_title：Journal of pediatric surgery
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pub_type： 杂志文章,meta分析,评审
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journal_title：Journal of pediatric surgery
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journal_title：Journal of pediatric surgery
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journal_title：Journal of pediatric surgery
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journal_title：Journal of pediatric surgery
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journal_title：Journal of pediatric surgery
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journal_title：Journal of pediatric surgery
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abstract：BACKGROUND/AIM:Cryptorchidism, or undescended testis (UDT) occurs in 1%-4% of newborn males and leads to a risk of infertility and testicular malignancy. Recent research suggests that infertility and malignancy in UDT may be caused by abnormal development of the neonatal germ cells, or gonocytes, which normally transfo...
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