Cryptorchidism, gonocyte development, and the risks of germ cell malignancy and infertility: A systematic review.


BACKGROUND/AIM:Cryptorchidism, or undescended testis (UDT) occurs in 1%-4% of newborn males and leads to a risk of infertility and testicular malignancy. Recent research suggests that infertility and malignancy in UDT may be caused by abnormal development of the neonatal germ cells, or gonocytes, which normally transform into spermatogonial stem cells (SSC) or undergo apoptosis during minipuberty at 2-6 months in humans (2-6 days in mice). We aimed to identify the current knowledge on how UDT is linked to infertility and malignancy. METHODS:Here we review the literature from 1995 to the present to assess the possible causes of infertility and malignancy in UDT, from both human studies and animal models. RESULTS:Both the morphological steps and many of the genes involved in germ cell development are now characterized, but the factors involved in gonocyte transformation and apoptosis in both normal and cryptorchid testes are not fully identified. During minipuberty there is evidence for the hypothalamic-pituitary axis stimulating gonocyte transformation, but without known direct control by LH and androgen, although FSH may have a role. An arrested gonocyte maybe the origin of later malignancy at least in syndromic cryptorchid testes in humans, which is consistent with the recent finding that gonocytes are normally absent in a rodent model of congenital cryptorchidism, where malignancy has not been reported. CONCLUSION:The results of this review strengthen the view that malignancy and infertility in men with previous UDT may be caused by abnormalities in germ cell development during minipuberty. TYPE OF STUDY:Systematic review (secondary, filtered) LEVEL OF EVIDENCE: Level I.


J Pediatr Surg


Loebenstein M,Thorup J,Cortes D,Clasen-Linde E,Hutson JM,Li R




Has Abstract


2020-07-01 00:00:00














  • Predictors of postoperative respiratory complications in premature infants after inguinal herniorrhaphy.

    abstract::There is a significant incidence of inguinal hernia in premature infants and the optimal timing of repair is controversial. A high rate of postoperative respiratory complications has been reported in this group. In this study, the records of 47 premature infants (mean gestational age, 30.3 weeks) who underwent hernior...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Gollin G,Bell C,Dubose R,Touloukian RJ,Seashore JH,Hughes CW,Oh TH,Fleming J,O'Connor T

    更新日期:1993-02-01 00:00:00

  • Inhibiting hydrogen sulfide production in umbilical stem cells reduces their protective effects during experimental necrotizing enterocolitis.

    abstract:INTRODUCTION:Umbilical mesenchymal stem cells (USC) have been shown to reduce illness in animal models of necrotizing enterocolitis (NEC), possibly through the paracrine release of hydrogen sulfide (H2S). We hypothesized that animals treated with USCs with inhibited H2S synthesis would exhibit more severe disease. MET...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Drucker NA,Te Winkel JP,Shelley WC,Olson KR,Markel TA

    更新日期:2019-06-01 00:00:00

  • Staple line ulcers: a cause of chronic GI bleeding following STEP procedure.

    abstract::Intestinal failure (IF) results from a critical reduction in the functional intestinal mass resulting in dependence on total parenteral nutrition (TPN) for growth and survival. Short bowel syndrome (SBS) is the most common cause of intestinal failure in pediatrics. Following resection, the small bowel undergoes adapta...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Gibbons TE,Casteel HB,Vaughan JF,Dassinger MS

    更新日期:2013-06-01 00:00:00

  • A Canadian national survey: understanding the differences in management of cryptorchidism among pediatric surgeons and pediatric urologists.

    abstract:BACKGROUND:This investigation aims to assess the variability in practice patterns regarding management of children with cryptorchidism (UDT) among pediatric urologists (U) and pediatric surgeons (S) practicing in Canada. METHODS:All active members of Pediatric Urologists of Canada (PUC) and Canadian Association of Ped...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kim JK,Chua M,Braga L,Langer JC,Hancock BJ,Lorenzo AJ,Bagli D,Farhat WA,Koyle MA

    更新日期:2019-09-01 00:00:00

  • The Cambridge experience with buried bumpers.

    abstract:AIM:Buried Bumper (BB) is a complication of percutaneous endoscopic gastrostomy (PEG) that leads to tube dysfunction and major morbidity. Although many techniques have been described to manage BB, none are universally adopted, and laparotomy remains the mainstay. We introduce a novel endoscopic technique in paediatric ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Goneidy A,Malakounides G,Aslam A

    更新日期:2019-02-01 00:00:00

  • Nasal glioma.

    abstract::In this report 12 cases of nasal glioma are reviewed. It is shown that they present in three different ways. The etiology, pathology, differential diagnosis, and treatment are discussed. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Alexander TA

    更新日期:1978-10-01 00:00:00

  • Intestinal trichobezoar with perforation in a child.

    abstract::A 4-year-old girl presented with a history and examination results suggestive of peritonitis. Exploration of abdomen was done with suspicion of enteric perforation, which showed long ileal trichobezoar with perforation of .5-cm diameter. The stomach was devoid to any fragment of bezoar. There was no history of hair ea...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Sharma V,Sharma ID

    更新日期:1992-04-01 00:00:00

  • External caliper-based measurements of the modified percent depth as an alternative to cross-sectional imaging for assessing the severity of pectus excavatum.

    abstract:BACKGROUND:Cross-sectional imaging (CSI) may be clinically unnecessary in the evaluation of pectus excavatum (PE). The purpose of our study was to prospectively evaluate the accuracy and reliability of the modified percent depth (MPD), derived from caliper-based external measurements, in identifying PE. METHODS:Childr...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,多中心研究


    authors: Bludevich BM,Kauffman JD,Litz CN,Farach SM,DeRosa JC,Wharton K,Potthast K,Danielson PD,Snyder CW,Chandler NM

    更新日期:2020-06-01 00:00:00

  • Vascular control for resection of suprahepatic intracaval Wilms' tumor: technical considerations.

    abstract::The surgical resection of Wilms' tumor can be complicated by tumor thrombus extension into the inferior vena cava. In cases of suprahepatic Wilms' tumor thrombus that may extend into the right atrium, a median sternotomy and cardiopulmonary bypass (CPB) are used to facilitate tumor resection. However, if the tumor can...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Lodge AJ,Jaggers J,Adams D,Rice HE

    更新日期:2000-12-01 00:00:00

  • Necrotizing enterocolitis as a prognostic factor for the neurodevelopmental outcome of preterm infants - match control study after 2years.

    abstract:PURPOSE:Necrotizing enterocolitis (NEC) in very low birth weight infants is a risk factor for developmental delay. To our knowledge, there are no studies published investigating the neurodevelopmental outcome of patients with NEC comparing surgically treated and conservatively treated patients versus match paired contr...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Allendorf A,Dewitz R,Weber J,Bakthiar S,Schloesser R,Rolle U

    更新日期:2018-08-01 00:00:00

  • Ex vivo testing of a temperature- and pressure-controlled amnio-irrigator for fetoscopic surgery.

    abstract:BACKGROUND:Currently, amnioinfusion fluids used in operative fetoscopy usually are preheated to body temperature. As the complexity of procedures increases, purposed designed devices should be designed that allow control of pressure and temperature during amnioinfusion or amnioexchange. In the current study, a prototyp...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bonati F,Perales A,Novak P,Barki G,Gratacós E,Nicolini U,Deprest JA

    更新日期:2002-01-01 00:00:00

  • Surgery in children with hydatid disease of the spleen.

    abstract:BACKGROUND/PURPOSE:Hydatid disease of the spleen is a rare disease, and it occurs in 1% to 8% of all children with hydatid disease. That difference in frequency depends on the social and economic status of the patients and the country. The aim of our study is to reveal its diagnosis and treatment. METHODS:From 1985 to...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kalinova K,Stefanova P,Bosheva M

    更新日期:2006-07-01 00:00:00

  • NADPH-diaphorase histochemistry: a reliable test for the intraoperative diagnosis of Hirschsprung's disease.

    abstract::Seromuscular biopsies were obtained from eight cases, at various levels, during a Swanson pull-through operation. The specimens were examined by using NADPH-diaphorase histochemistry. In the ganglionic segment of bowel, there were a large number of NADPH-diaphorase-positive nerve fibers in the circular and longitudina...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kobayashi H,Hirakawa H,Puri P

    更新日期:1996-11-01 00:00:00

  • Cell proliferation and apoptosis in experimental lung hypoplasia.

    abstract:BACKGROUND/PURPOSE:Current treatment for lethal pulmonary hypoplasia in congenital diaphragmatic hernia (CDH) may be hampered by uncertainty over its origin. Herniation of abdominal organs into the chest was thought to produce lung hypoplasia by compression. Experimental CDH models suggest that disturbed lung growth pr...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Jesudason EC,Connell MG,Fernig DG,Lloyd DA,Losty PD

    更新日期:2000-01-01 00:00:00

  • Urinary diversion in children with pelvic tumors.

    abstract:PURPOSE:The aim of this study was to investigate children presenting with malignant pelvic tumors obstructing the upper urinary tract. METHODS:Seventeen children with upper urinary tract obstruction by a malignant tumor were reviewed. A nephrostomy tube or Double J (DJ) stent was inserted into each obstructed urinary ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Meir DB,Inoue M,Gur U,Livne PM,Yaniv Y,Tiedeman K,Ashley DM,Hutson JM

    更新日期:2004-12-01 00:00:00

  • The risk factors and clinical significance of acute postoperative complications after unstented pediatric pyeloplasty: a single surgeon's experience.

    abstract:PURPOSE:To analyze the risk factors and clinical significance of postoperative complications after unstented pediatric pyeloplasty. MATERIALS AND METHODS:We analyzed 285 kidney units (KUs) on which unstented pyeloplasty was performed between April 2002 and March 2010. Measures included preoperative factors, postoperat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Lee YS,Lee CN,Kim MU,Jang WS,Lee H,Im YJ,Han SW

    更新日期:2014-07-01 00:00:00

  • Intracranial pressure monitoring in the management of the pediatric trauma patient.

    abstract::Intracranial pressure (ICP) monitoring is an important adjunct in the management of the severely injured child with major head trauma. From a series of 18 patients with multiple trauma, smoke inhalation, and near-drowning, we report an illustrative case of head injury and pulmonary aspiration in which ICP monitoring w...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Caniano DA,Nugent SK,Rogers MC,Haller JA

    更新日期:1980-08-01 00:00:00

  • Repair of gastroschisis with preservation of the umbilicus.

    abstract::A simplified technique for the repair of gastroschisis without the need to excise the umbilicus or make a fascial incision has been developed. First, the abdominal wall is stretched and the viscera are reduced. Next, the skin and subcutaneous tissue are elevated from the fascia for 1.5 cm around the defect and the fas...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Wesson DE,Baesl TJ

    更新日期:1986-09-01 00:00:00

  • BAPS prize-1999: Lung growth induced by prenatal tracheal occlusion and its modifying factors: a study in the rat model of congenital diaphragmatic hernia.

    abstract:BACKGROUND/PURPOSE:Prenatal tracheal occlusion (TO) has been shown to accelerate lung growth in animal models and models of pulmonary hypoplasia. However, these models may not mimic early events in human congenital diaphragmatic hernia (CDH). The authors previously have developed a model of TO in the rat. The purpose o...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kitano Y,Kanai M,Davies P,von Allmen D,Yang EY,Radu A,Kitano Y,Adzick NS,Flake AW

    更新日期:2001-02-01 00:00:00

  • A histopathological study of the remnant of extrahepatic bile duct in so-called uncorrectable biliary atresia.

    abstract::Histopathological study of the remnant of extrahepatic bile ducts in 40 cases of so-called uncorrectable biliary atresia, upon which we operated the last three years, has been performed. The histological findings of the remnant were classified into three types. Only two cases were found to have type 1a ducts in the po...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Miyano T,Suruga K,Tsuchiya H,Suda K

    更新日期:1977-02-01 00:00:00

  • Percutaneous transhepatic cholangiography (PTC) in biliary atresia with special reference to the structure of the intrahepatic bile ducts.

    abstract::Percutaneous transhepatic cholangiography (PTC) was carried out in 30 cases of biliary atresia, 19 prior to surgery, and 11 following hepatic portoenterostomy. The intrahepatic biliary system was demonstrated in 47% of the patients prior to surgery and in all cases following surgery. Two distinct patterns of intrahepa...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Hashimoto T,Yura J

    更新日期:1981-02-01 00:00:00

  • P-glycoprotein status of favorable-histology Wilms' tumor predicts treatment outcome.

    abstract::Patients with advanced-stage favorable-histology (FH) Wilms' tumor have a 4-year relapse-free survival rate of 70% to 90% after resection and chemotherapy of actinomycin D, vincristine, and doxorubicin. These three agents are actively pumped out of cells by P-glycoprotein (Pgp). The authors studied whether Wilms' tumo...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Sola JE,Wojno KJ,Dooley W,Colombani PM

    更新日期:1994-08-01 00:00:00

  • Case report of an 11-year-old child with a nonfunctional malignant pheochromocytoma.

    abstract::Pheochromocytoma is an unusual cause of surgical hypertension and is extremely rare in the pediatric population. We present a case of a hypertension-producing malignant pheochromocytoma in an 11-year-old, which was initially unresectable. The tumor responded partially to aggressive chemotherapy and was completely rese...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Holwitt D,Neifeld J,Massey G,Lanning D

    更新日期:2007-11-01 00:00:00

  • Serum and erythrocyte acetylcholinesterase activity in Hirschsprung's disease.

    abstract::Acetylcholinesterase activity was measured in the serum and erythrocytes from 22 children. The 12 patients in whom the diagnosis of Hirschsprung's disease was confirmed, had a significantly higher concentration of enzyme in both serum and erythrocytes than the 10 children in whom the diagnosis was excluded. This syste...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Boston VE,Cywes S,Davies MR

    更新日期:1978-08-01 00:00:00

  • Ileal exclusion for Byler's disease: an alternative surgical approach with promising early results for pruritus.

    abstract:BACKGROUND/PURPOSE:Progressive familial intrahepatic cholestasis (Byler's disease) is often characterized by pruritus-induced self-mutilation with minimal response to medical therapy. The causative cholestasis is likely to progress to cirrhosis necessitating transplantation. Partial external biliary diversion has been ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Hollands CM,Rivera-Pedrogo FJ,Gonzalez-Vallina R,Loret-de-Mola O,Nahmad M,Burnweit CA

    更新日期:1998-02-01 00:00:00

  • Distal spleno-renal shunt for portal decompression in childhood.

    abstract::Successful portal decompression presents a unique challenge in children. The meso-caval shunt, utilizing the large caliber iliac vein in constructing the anastomosis, has been accepted as the standard operative procedure for treating these patients. Technical and anatomic difficulties, however, often prevent the succe...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Rodgers BM,Talbert JL

    更新日期:1979-02-01 00:00:00

  • Pyriform sinus cyst and fistula in the newborn: the value of endoscopic cannulation.

    abstract::A case of pyriform sinus cyst and fistula presenting in the neonatal period is described. Endoscopic cannulation of the fistula tract was used to confirm the diagnosis and to simplify the resection. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Tyler D,Effmann E,Shorter N

    更新日期:1992-12-01 00:00:00

  • Inflammatory cloacogenic polyps in children.

    abstract::Inflammatory cloacogenic polyp (ICP) is a rare lesion arising in the region of the anorectal transitional zone. It is likely caused by occult internal prolapse. Most cases reported in the literature are in the adult population. This is a report of ICP in four children. Awareness of this entity in children is important...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bass J,Soucy P,Walton M,Nizalik E

    更新日期:1995-04-01 00:00:00

  • Selective management of pediatric pancreatic injuries.

    abstract:BACKGROUND:Despite trauma being the most common cause of pediatric pancreatitis, the diagnosis and management is often difficult. METHODS:The hospital course, diagnostic and surgical procedures, and complications for all children with traumatic pancreatitis evaluated at a Regional Level I Trauma Center were reviewed r...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Firstenberg MS,Volsko TA,Sivit C,Stallion A,Dudgeon DL,Grisoni ER

    更新日期:1999-07-01 00:00:00

  • A prospective randomized double-blind trial of bolus urokinase in the treatment of established Hickman catheter sepsis in children.

    abstract:BACKGROUND:The incidence of Hickman catheter sepsis is 10% to 40%, with resultant catheter loss in one third of infections. Urokinase causes dissolution of colonized intracatheter fibrin thrombi and may improve salvage. STUDY AIMS:To evaluate the efficacy of 12-hour-interval slow-push urokinase infusion in addition to...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: La Quaglia MP,Caldwell C,Lucas A,Corbally M,Heller G,Steinherz L,Brown AE,Groeger J,Exelby PR

    更新日期:1994-06-01 00:00:00