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Chloro-benzoquinones cause oxidative DNA damage through iron-mediated ROS production in Escherichia coli.

Abstract：

:Chloro-benzoquinones (CBQs) are a group of disinfection byproducts that are suspected to be potentially carcinogenic. Here, the mechanism of DNA damage caused by CBQs in the presence of ferrous ions was investigated in an Escherichia coli wild type M5 strain and a mutant L5 (ahpCF katEG mutant) strain that carried an enhanced green fluorescent protein reporter under the control of a SOS response gene (recA) promoter. All tested CBQs (including para-benzoquinone, 2-chloro-para-benzoquinone, and dichloro-para-benzoquinones with different substitutes) caused substantial oxidative DNA damage with EC50 values in the micromolar range. Moreover, 2,5-dichloro-para-benzoquinone (2,5-DCBQ), a typical CBQ, caused substantial ROS production in E. coli mutant cells. And ROS scavengers provided partial protective effects on genotoxicity of 2,5-DCBQ to E. coli mutant cells. The addition of Fe(2+) to the 2,5-DCBQ exposure system caused an increase in DNA oxidative damage; iron-chelating agents could partially prevent these cells from DNA damage. Finally, intracellular AhpCF, catalase E, and catalase G were all found to play an important role in the survival of E. coli cells exposed to CBQs, as indicated by an increased sensitivity of the ahpCF katEG mutant L5 strain to treatment compared with wild type M5 cells. Taken together, these results suggest that CBQs cause oxidative DNA damage in E. coli cells through the participation of iron-mediated ROS production.

journal_name

Chemosphere

journal_title

Chemosphere

authors

Chen Z,Zhou Q,Zou D,Tian Y,Liu B,Zhang Y,Wu Z

doi

10.1016/j.chemosphere.2015.04.076

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

379-86

eissn

0045-6535

issn

1879-1298

pii

S0045-6535(15)00422-1

journal_volume

135

pub_type

杂志文章

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