Abstract:
PURPOSE:To correlate intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters with the enhancement patterns of bone marrow and focal lesion obtained on whole-body (WB) dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) images in patients with stage-III multiple myeloma (MM) before and after systemic therapy. MATERIALS AND METHODS:Twenty-seven patients with MM were retrospectively included in this institutional review board-approved study. Requirement for written informed consent was waived. All patients underwent WB DCE MR imaging before treatment and 18 patients underwent repeat MR imaging 3 months after treatment. A transverse IVIM DWI sequence with 10 b values (0, 10, 20, 30, 50, 80, 100, 200, 400, and 800 sec/mm(2)) was acquired within bone marrow and focal lesions. The IVIM parameters (perfusion fraction [f], molecular diffusion coefficient [D], and perfusion-related D [D*]) and apparent diffusion coefficient (ADC) were extracted for both focal lesions and bone marrow and correlated with focal lesions and maximal bone marrow enhancement (BMEmax) (Spearman correlation coefficient) at baseline and at follow-up (Wilcoxon signed-rank test). RESULTS:D and ADC values positively correlated with BMEmax (r = 0.7, P < .001; and r = 0.455, P = .0435, respectively). Patients with increased BMEmax showed significantly increased ADC and D within bone marrow versus patients who did not have increased BMEmax (ADC, 0.67 × 10(-3) mm(2)/sec vs 0.54 × 10(-3) mm(2)/sec, P = .03; D, 0.58 × 10(-3) mm(2)/sec vs 0.42 × 10(-3) mm(2)/sec, P < .001). Within focal lesions, f was the maximum in lesions that showed enhancement followed by washout. After treatment in good responders, the significant decrease in maximal enhancement value of focal lesions (baseline vs after treatment, 213.9% ± 78.7 [standard deviation] vs 131% ± 53.6, respectively; P < .001) was accompanied by a significant decrease in f (baseline vs after treatment, 11% ± 3.8 vs 5.8% ± 4.7, respectively; P < .001). CONCLUSION:Diffuse bone marrow involvement is associated with increased D. Hypervascular focal lesions with high maximal enhancement value of focal lesions also show high f value. Likewise, the decreased maximal enhancement value of focal lesions after treatment is accompanied by decreased f.
journal_name
Radiologyjournal_title
Radiologyauthors
Bourillon C,Rahmouni A,Lin C,Belhadj K,Beaussart P,Vignaud A,Zerbib P,Pigneur F,Cuenod CA,Bessalem H,Cavet M,Boutekadjirt A,Haioun C,Luciani Adoi
10.1148/radiol.2015141728subject
Has Abstractpub_date
2015-12-01 00:00:00pages
773-83issue
3eissn
0033-8419issn
1527-1315journal_volume
277pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract:PURPOSE:To compare the postdural puncture headache (PDPH) rates after myelography with use of 22-gauge Whitacre (blunt tip) versus standard 22-gauge Quincke (bevel-tip) spinal needles. MATERIALS AND METHODS:At myelography, 340 patients were randomly assigned to one of two groups in which either the Whitacre (167 patie...
journal_title:Radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1148/radiology.200.3.8756930
更新日期:1996-09-01 00:00:00
abstract::The authors report a case of renal cell carcinoma in which computed tomography (CT) revealed fatty tissue and calcification within a solid renal mass. The detection of a mass with negative CT numbers at CT and increased echogenicity at ultrasound led to the incorrect diagnosis of angiomyolipoma (renal hamartoma). The ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.188.2.8327690
更新日期:1993-08-01 00:00:00
abstract::A case of tuberculosis mimicking carcinoma in the distal colon is reported. The difficulty in diagnosing a solitary tuberculous colonic lesion, a review of the literature, and a differential diagnosis are presented. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/118.2.293
更新日期:1976-02-01 00:00:00
abstract::Haglund syndrome is a common cause of posterior heel pain, characterized clinically by a painful soft-tissue swelling at the level of the achilles tendon insertion. On the lateral heel radiograph the syndrome is characterized by a prominent calcaneal bursal projection, retrocalcaneal bursitis, thickening of the Achill...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.144.1.7089270
更新日期:1982-07-01 00:00:00
abstract:PURPOSE:To determine if digital chest images could be compressed in a primary interpretation context without perceived loss of fidelity (below the visually lossless threshold) at transilluminated film or cathode ray tube (CRT) display. MATERIALS AND METHODS:One hundred forty-four posteroanterior radiographs were obtai...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2282011998
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:To assess placental perfusion and permeability in mice with magnetic resonance (MR) imaging. MATERIALS AND METHODS:This study was conducted according to French law and National Institutes of Health recommendations for animal care. Twenty-two pregnant BALB/c mice were examined at 1.5 T with a single-section dua...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2413051168
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:To prospectively evaluate multiobserver diagnostic performance and reader agreement for colorectal polyp detection in a well-characterized cohort of patients with increased number of polyps, compared with an average-risk patient, with colonoscopy as the reference standard. MATERIALS AND METHODS:A cohort of 70 ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2252011625
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To assess the value of magnetic resonance (MR) imaging in the diagnosis of pelvic inflammatory disease (PID) and to compare MR imaging with transvaginal ultrasonography (US) and laparoscopy. MATERIALS AND METHODS:Thirty consecutive patients hospitalized because they were clinically suspected of having PID unde...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.210.1.r99ja04209
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To assess the reproducibility and accuracy of volumetric quantifications of articular cartilage in the knee determined with three-dimensional (3D) magnetic resonance (MR) imaging combined with pulsed saturation transfer subtraction (STS) or T1-weighted fat suppression (FS) imaging. MATERIALS AND METHODS:Eight ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.192.2.8029420
更新日期:1994-08-01 00:00:00
abstract::During the past few years, several articles have appeared in the scientific literature that predict thousands of cancers and cancer deaths per year in the U.S. population caused by medical imaging procedures that use ionizing radiation. These predictions are computed by multiplying small and highly speculative risk fa...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.12112678
更新日期:2012-08-01 00:00:00
abstract::Eighty-nine biliary strictures in 73 patients who had undergone percutaneous balloon dilatation were reviewed to determine long-term patency rates and clinical management problems. The majority of dilatations were performed in patients with anastomotic strictures (n = 44), iatrogenic strictures (n = 28), and stricture...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.160.1.3715030
更新日期:1986-07-01 00:00:00
abstract::Local relapse was suspected in 26 women treated conservatively for breast cancer. All women underwent routine magnetic resonance (MR) imaging and a dynamic MR subtraction study after injection of gadolinium-tetraazacyclododecanetetra-acetic acid. Twelve women had no local relapse. Surgical biopsy enabled confirmation ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.188.2.8327700
更新日期:1993-08-01 00:00:00
abstract:PURPOSE:To quantitatively determine the delivery of systemic liposomal doxorubicin to tumors treated with pulsed high-intensity focused ultrasound and to study the mechanism underlying this delivery in a murine model. MATERIALS AND METHODS:All animal work was performed in compliance with guidelines and approval of ins...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2342030889
更新日期:2005-02-01 00:00:00
abstract::The anterior humeral line is a valuable aid in the search for supracondylar fractures in children. When it is abnormal other signs of fracture should be carefully sought. The AHL was normal in only 5.8% of the cases reviewed (4 of 68 cases). There was other evidence of fracture in each case. Comparison of the AHLs on ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/128.1.145
更新日期:1978-07-01 00:00:00
abstract::Ultrasound guidance was used in 10 aspiration and six drainage procedures in the intensive care unit. Sonography offered a safe and effective method for guidance of diagnostic aspiration in the ICU setting. Additionally, cholecystostomy, nephrostomy, abscess drainage, and empyema drainage were performed at bedside as ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.154.2.3966140
更新日期:1985-02-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic usefulness of the combined application of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG; for the evaluation of soft tissue) and [F-18]fluoride (for the evaluation of the skeleton) in positron emission tomography (PET) of cancer. MATERIALS AND METHODS:Sixty consecutive patients (23 wom...
journal_title:Radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1148/radiology.209.1.9769840
更新日期:1998-10-01 00:00:00
abstract:PURPOSE:To evaluate fluorine 18 ((18)F) dihydroxyphenylalanine (DOPA) whole-body positron emission tomography (PET) as a biochemical imaging approach for detection of pheochromocytomas. MATERIALS AND METHODS:(18)F DOPA PET and magnetic resonance (MR) imaging were performed in 14 consecutive patients suspected of havin...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2222010622
更新日期:2002-02-01 00:00:00
abstract::Radiologic evaluation of frontal sinus fractures is instrumental in determining the need for surgery. Computed tomography (CT) is an excellent modality for evaluation of frontal sinus trauma, particularly for anterior and posterior wall fractures. However, fractures of the nasofrontal duct are more difficult to deline...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.165.1.3628770
更新日期:1987-10-01 00:00:00
abstract::Eighteen cases of long-standing rheumatoid arthritis and superimposed pyarthrosis were reviewed to determine the most distinguishing radiographic features. Soft-tissue changes allowed earlier diagnosis in the knee and ankle joints and consisted of large asymmetrical joint effusion and fat-pad edema. Bony articular cha...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/122.1.17
更新日期:1977-01-01 00:00:00
abstract:PURPOSE:To evaluate the data acquired over 2 1/2 years regarding the use of mechanical thrombolysis as the routine, preferred treatment for thrombosed access grafts in a large patient population undergoing hemodialysis. MATERIALS AND METHODS:Mechanical thrombolysis was performed in 1,176 cases. Data were collected on ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.200.3.8756920
更新日期:1996-09-01 00:00:00
abstract::Twenty-nine patients with known or suspected malignancy were studied with identical T1-weighted (spin echo [SE] and inversion recovery [IR]) and T2-weighted SE magnetic resonance (MR) imaging at 0.5 and 1.5 T to evaluate the relative sensitivities of these sequences for detecting focal hepatic lesions. At 0.5 T, 98 le...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.174.1.2152980
更新日期:1990-01-01 00:00:00
abstract::To determine the prevalence of "nonobstructive" (impairment of gas transfer) emphysema in a select population of smokers with dyspnea, a retrospective study of patients with emphysema evident at high-resolution computed tomography (HRCT) was undertaken. Four hundred seventy HRCT studies were reviewed. In 47 cases, cen...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.182.3.1535900
更新日期:1992-03-01 00:00:00
abstract:PURPOSE:To determine whether silver-coated tunneled hemodialysis catheters reduce infection and to determine the frequency of central venous thrombosis and stenosis with percutaneous placement of right internal jugular vein dialysis catheters by interventional radiologists. MATERIALS AND METHODS:Ninety-one patients we...
journal_title:Radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1148/radiology.207.2.9577500
更新日期:1998-05-01 00:00:00
abstract::The authors used color Doppler ultrasonography (US) to evaluate 33 children with suspected appendicitis and found locally increased blood flow in all of 10 patients with appendicitis or periappendiceal abscess; the studies were normal in 16 patients without appendicitis. The gray-scale sonographic results were concord...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.184.3.1509060
更新日期:1992-09-01 00:00:00
abstract::The line spread function (LSF) and modulation transfer function (MTF) of 9 rare-earth screen/film systems were measured and compared with those of two fast calcium tungstate systems, using double-emulsion films sandwiched between two screens and mounted in regular cassettes. The LSFs were found to fit exponential func...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/121.2.473
更新日期:1976-11-01 00:00:00
abstract::The goals of reconstructive surgery for scaphoid fracture nonunions include restoration of normal scaphoid length and shape by use of the contralateral scaphoid bone as a geometric model. A literature search revealed limited documentation of normal biometric measurements and no validation of scaphoid anatomic symmetry...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.187.1.8451410
更新日期:1993-04-01 00:00:00
abstract::One hundred twenty-five patients with biopsy proved clinical stage A or B prostatic carcinoma were evaluated with biplane transrectal ultrasonography (US) prior to radical prostatectomy. Sonograms were evaluated for capsular transgression of the tumor into the posterior and posterolateral aspects of the glands as mani...
journal_title:Radiology
pub_type: 临床试验,杂志文章
doi:10.1148/radiology.178.3.1994420
更新日期:1991-03-01 00:00:00
abstract:PURPOSE:To analyze asymptomatic adnexal masses at positron emission tomography (PET) with fluorodeoxyglucose (FDG) in correlation with histopathologic findings and evaluate FDG PET for assessing malignancy in comparison with transvaginal B-mode and Doppler ultrasonography (US) and magnetic resonance (MR) imaging. MATE...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2233001850
更新日期:2002-06-01 00:00:00
abstract:PURPOSE:To report the prevalence of qualitative radiographic findings for femoroacetabular impingement (FAI) and associations among them and to characterize the inter- and intraobserver variability of these interpretations. MATERIALS AND METHODS:This study is part of an institutional review board-approved population-b...
journal_title:Radiology
pub_type: 杂志文章,随机对照试验
doi:10.1148/radiol.11102354
更新日期:2011-08-01 00:00:00
abstract::Twenty cases of methadone-induced pulmonary edema confirmed by clinical, laboratory and roentgenographic findings were extensively reviewed and the roentgenographic manifestations defined in terms of patterns, distribution, and duration of the process. Drug tolerance is a major factor in determining the severity of to...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/114.1.51
更新日期:1975-01-01 00:00:00