Combined FDG and [F-18]fluoride whole-body PET: a feasible two-in-one approach to cancer imaging?

Abstract:

PURPOSE:To evaluate the diagnostic usefulness of the combined application of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG; for the evaluation of soft tissue) and [F-18]fluoride (for the evaluation of the skeleton) in positron emission tomography (PET) of cancer. MATERIALS AND METHODS:Sixty consecutive patients (23 women, 37 men; mean age +/- SD, 51 years +/- 14; age range, 13-76 years) were entered into this prospective study. Thirty patients underwent only FDG PET. Thirty patients underwent combined FDG and fluoride PET. The PET findings were correlated with the findings of other imaging modalities. Interobserver agreement for the anatomic lesion localization was calculated with the use of the kappa statistic. RESULTS:All 30 combined FDG and fluoride studies yielded high-quality whole-body images. PET findings correlated with other imaging findings in 54 (78%) of 69 lesions in the control group and with 64 (88%) of 73 lesions in the combined group. Interobserver agreement in the control group was 0.74; it was 0.95 in the combined group. CONCLUSION:Combined FDG and fluoride PET is an advanced metabolic imaging approach for the evaluation of cancer.

journal_name

Radiology

journal_title

Radiology

authors

Hoegerle S,Juengling F,Otte A,Altehoefer C,Moser EA,Nitzsche EU

doi

10.1148/radiology.209.1.9769840

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

253-8

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

209

pub_type

临床试验,杂志文章,随机对照试验
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