Abstract：
UNLABELLED:Next generation sequencing and proteomics have helped to comprehensively characterize gene expression in tick salivary glands at both the transcriptome and the proteome level. Functional data are, however, lacking. Given that tick salivary secretions are critical to the success of the tick transmission lifecycle and, as a consequence, for host colonization by the pathogens they spread, we thoroughly review here the literature on the known interactions between tick saliva (or tick salivary gland extracts) and the innate and adaptive vertebrate immune system. The information is intended to serve as a reference for functional characterization of the numerous genes and proteins expressed in tick salivary glands with an ultimate goal to develop novel vector and pathogen control strategies. SIGNIFICANCE:We overview all the known interactions of tick saliva with the vertebrate immune system. The provided information is important, given the recent developments in high-throughput transcriptomic and proteomic analysis of gene expression in tick salivary glands, since it may serve as a guideline for the functional characterization of the numerous newly-discovered genes expressed in tick salivary glands.
journal_name
J Proteomicsjournal_title
Journal of proteomicsauthors
Kotál J,Langhansová H,Lieskovská J,Andersen JF,Francischetti IM,Chavakis T,Kopecký J,Pedra JH,Kotsyfakis M,Chmelař Jdoi
10.1016/j.jprot.2015.07.005subject
Has Abstractpub_date
2015-10-14 00:00:00pages
58-68eissn
1874-3919issn
1876-7737pii
S1874-3919(15)30061-0journal_volume
128pub_type
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