An integrated approach for probing the structure and mechanical properties of diatoms: Toward engineered nanotemplates.

Abstract:

:The wide variety of diatom frustule shapes and intricate architectures provide viable prototypes to guide the design and fabrication of nanodevices and nanostructured materials for applications ranging from sensors to nanotemplates. In this study, a combined experimental-simulation method was developed to probe the porous structure and mechanical behavior of two distinct marine diatom species, Coscinodiscus sp. (centric) and Synedra sp. (pennate), through ambient nanoindentation and finite element method analysis. These diatom frustule dimensions differed largely depending on diatom species with pore diameters d ranging from 0.3 to 3.0 μm. Young's modulus E and hardness H measurements of the diatom frustules were obtained via nanoindentation experiments. These values varied depending on diatom species (E between 1.1-10.6 GPa, H between 0.10-1.03 GPa for the Coscinodiscus sp.; and E between 13.7-18.6 GPa, H between 0.85-1.41 GPa for the Synedra sp.). Additionally, the mechanical response of diatom structures to uniform compression was examined. Predictive simulations were performed on the aforementioned diatom frustules, as well as another diatom structure (pennate Fragilariopsis kerguelensis), to correlate the mechanical response with specific morphology variables (e.g., pore or slit sizes). Results from calculated von Mises stress and displacement distributions unveil unique information on the effect that uniform loads have on these frustules, which can aid the design of tailored nanotemplates. A correlation between mechanical properties and porosity was established for selected frustules, and reported for the first time in this study.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Moreno MD,Ma K,Schoenung J,Dávila LP

doi

10.1016/j.actbio.2015.07.028

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

313-24

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(15)30026-X

journal_volume

25

pub_type

杂志文章
  • Absorption performance of iodixanol-imprinted polymers in aqueous and blood plasma media.

    abstract::This paper presents the preparation and absorption performance of iodixanol-imprinted polymers in aqueous and blood plasma media in vitro for biomedical applications. The imprinted polymers were prepared by non-covalent imprinting of iodixanol in a matrix of poly(4-vinylpyridine) crosslinked by ethylene glycol dimetha...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2009.11.007

    authors: Liu Z,Bucknall DG,Allen MG

    更新日期:2010-06-01 00:00:00

  • Nano-scale modification of titanium implant surfaces to enhance osseointegration.

    abstract::The main aim of this review study was to report the state of art on the nano-scale technological advancements of titanium implant surfaces to enhance the osseointegration process. Several methods of surface modification are chronologically described bridging ordinary methods (e.g. grit blasting and etching) and advanc...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审

    doi:10.1016/j.actbio.2019.05.045

    authors: Souza JCM,Sordi MB,Kanazawa M,Ravindran S,Henriques B,Silva FS,Aparicio C,Cooper LF

    更新日期:2019-08-01 00:00:00

  • Biomimetic hydrogel with tunable mechanical properties for vitreous substitutes.

    abstract:UNLABELLED:The vitreous humor of the eye is a biological hydrogel principally composed of collagen fibers interspersed with hyaluronic acid. Certain pathological conditions necessitate its removal and replacement. Current substitutes, like silicone oils and perfluorocarbons, are not biomimetic and have known complicati...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.07.051

    authors: Santhanam S,Liang J,Struckhoff J,Hamilton PD,Ravi N

    更新日期:2016-10-01 00:00:00

  • Effect of nanostructure on osteoinduction of porous biphasic calcium phosphate ceramics.

    abstract::In order to evaluate the effect of the nanostructure of calcium phosphate ceramics on osteoinductive potential, porous biphasic calcium phosphate (BCP) ceramics with a nano- or submicron structure were prepared via microwave sintering and compared to conventional BCP ceramics. The selective protein adsorption of bovin...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,收录出版

    doi:10.1016/j.actbio.2012.06.021

    authors: Li B,Liao X,Zheng L,Zhu X,Wang Z,Fan H,Zhang X

    更新日期:2012-10-01 00:00:00

  • Advanced silk material spun by a transgenic silkworm promotes cell proliferation for biomedical application.

    abstract::Natural silk fiber spun by the silkworm Bombyx mori is widely used not only for textile materials, but also for biofunctional materials. In the present study, we genetically engineered an advanced silk material, named hSFSV, using a transgenic silkworm, in which the recombinant human acidic fibroblast growth factor (h...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2014.06.031

    authors: Wang F,Xu H,Wang Y,Wang R,Yuan L,Ding H,Song C,Ma S,Peng Z,Peng Z,Zhao P,Xia Q

    更新日期:2014-12-01 00:00:00

  • Optimized in vitro procedure for assessing the cytocompatibility of magnesium-based biomaterials.

    abstract::Magnesium (Mg) is a promising biomaterial for degradable implant applications that has been extensively studied in vitro and in vivo in recent years. In this study, we developed a procedure that allows an optimized and uniform in vitro assessment of the cytocompatibility of Mg-based materials while respecting the stan...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2015.06.005

    authors: Jung O,Smeets R,Porchetta D,Kopp A,Ptock C,Müller U,Heiland M,Schwade M,Behr B,Kröger N,Kluwe L,Hanken H,Hartjen P

    更新日期:2015-09-01 00:00:00

  • Hydroxyapatite coating affects the Wnt signaling pathway during peri-implant healing in vivo.

    abstract::Owing to its bio- and osteoconductivity, hydroxyapatite (HA) is a widely used implant material, but its osteogenic properties are only partly evaluated in vitro and in vivo. The present study focused on bone healing adjacent to HA-coated titanium (Ti) implants, with or without incorporated lithium ions (Li(+)). Specia...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2013.12.012

    authors: Thorfve A,Lindahl C,Xia W,Igawa K,Lindahl A,Thomsen P,Palmquist A,Tengvall P

    更新日期:2014-03-01 00:00:00

  • A sustained intravitreal drug delivery system with remote real time monitoring capability.

    abstract:UNLABELLED:Many chorioretinal diseases are chronic and need sustained drug delivery systems to keep therapeutic drug level at the disease site. Many intravitreal drug delivery systems under developing do not have mechanism incorporated for a non-invasive monitoring of drug release. The current study prepared rugate por...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2015.06.012

    authors: Hou H,Nieto A,Belghith A,Nan K,Li Y,Freeman WR,Sailor MJ,Cheng L

    更新日期:2015-09-01 00:00:00

  • Unraveling the role of β1 integrin isoforms in cRGD-mediated uptake of nanoparticles bearing hydrophilized alkyne moieties in epithelial and endothelial cells.

    abstract::The uptake and trafficking of NPs is impacted by several attributes such as size, shape, surface charge and importantly by surface ligands that can interact with the cell plasma membrane. We envision that NPs which can be readily modified in aqueous environments will be key to engineering patient-specific nanotherapeu...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2020.08.038

    authors: Zhang W,Teske N,Samadi M,Sarem M,Shastri VP

    更新日期:2020-10-15 00:00:00

  • Self-assembled composite matrix in a hierarchical 3-D scaffold for bone tissue engineering.

    abstract::It is of high clinical relevance in bone tissue engineering that scaffolds promote a high seeding efficiency of cells capable of osteogenic differentiation, such as human bone marrow-derived mesenchymal stem cells (hMSCs). We evaluated the effects of a novel polycaprolactone (PCL) scaffold on hMSC seeding efficiency, ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2010.12.031

    authors: Chen M,Le DQ,Baatrup A,Nygaard JV,Hein S,Bjerre L,Kassem M,Zou X,Bünger C

    更新日期:2011-05-01 00:00:00

  • Cell-laden hydrogel/titanium microhybrids: Site-specific cell delivery to metallic implants for improved integration.

    abstract:UNLABELLED:Porous titanium implants are widely used in dental, orthopaedic and otorhinolaryngology fields to improve implant integration to host tissue. A possible step further to improve the integration with the host is the incorporation of autologous cells in porous titanium structures via cell-laden hydrogels. Fast ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.01.023

    authors: Koenig G,Ozcelik H,Haesler L,Cihova M,Ciftci S,Dupret-Bories A,Debry C,Stelzle M,Lavalle P,Vrana NE

    更新日期:2016-03-01 00:00:00

  • Cell sheet mechanics: How geometrical constraints induce the detachment of cell sheets from concave surfaces.

    abstract::Despite of the progress made to engineer structured microtissues such as BioMEMS and 3D bioprinting, little control exists how microtissues transform as they mature, as the misbalance between cell-generated forces and the strength of cell-cell and cell-substrate contacts can result in unintended tissue deformations an...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.08.044

    authors: Yamashita T,Kollmannsberger P,Mawatari K,Kitamori T,Vogel V

    更新日期:2016-11-01 00:00:00

  • Cathodic voltage-controlled electrical stimulation of titanium for prevention of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii biofilm infections.

    abstract::Antibiotic resistance of bacterial biofilms limits available treatment methods for implant-associated orthopaedic infections. This study evaluated the effects of applying cathodic voltage-controlled electrical stimulations (CVCES) of -1.5V and -1.8V (vs. Ag/AgCl) to coupons of commercially pure titanium (cpTi) incubat...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.11.056

    authors: Canty M,Luke-Marshall N,Campagnari A,Ehrensberger M

    更新日期:2017-01-15 00:00:00

  • Chitosan layered gold nanorods as synergistic therapeutics for photothermal ablation and gene silencing in triple-negative breast cancer.

    abstract:UNLABELLED:Small interfering RNAs (siRNAs) are extensively studied due to their promising potential as therapeutic agents for a wide variety of diseases, including cancer. However, efficient delivery of siRNAs to target cells and tissues is problematic due to a lack of suitable delivery vehicles. In this work, we devel...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2015.07.026

    authors: Yang Z,Liu T,Xie Y,Sun Z,Liu H,Lin J,Liu C,Mao ZW,Nie S

    更新日期:2015-10-01 00:00:00

  • Study and evaluation of mechanisms of dual targeting drug delivery system with tumor microenvironment assays compared with normal assays.

    abstract::A dual targeting delivery system was developed to completely conquer the two barriers that glioma treatment faces: the blood-brain barrier (BBB) and the brain-glioma barrier. Recently, a system comprising AS1411 aptamer (for glioma targeting) and TGN peptide (for BBB targeting) modified nanoparticles (AsTNPs) was deve...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2013.11.003

    authors: Gao H,Yang Z,Zhang S,Pang Z,Liu Q,Jiang X

    更新日期:2014-02-01 00:00:00

  • Advanced technology-driven therapeutic interventions for prevention of tendon adhesion: design, intrinsic and extrinsic factor considerations.

    abstract::Tendon adhesion formation describes the development of fibrotic tissue between the tendon and its surrounding tissues, which commonly occurs as a reaction to injury or surgery. Its impact on function and quality of life varies from negligible to severely disabling, depending on the affected area and extent of adhesion...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审

    doi:10.1016/j.actbio.2021.01.027

    authors: Zhang Q,Yang Y,Yildirimer L,Xu T,Zhao X

    更新日期:2021-01-25 00:00:00

  • Continuous microfluidic encapsulation of single mesenchymal stem cells using alginate microgels as injectable fillers for bone regeneration.

    abstract::The encapsulation of cells in microscale hydrogels can provide a mimic of a three-dimensional (3D) microenvironment to support cell viability and functions and to protect cells from the environmental stress, which have been widely used in tissue regeneration and cell therapies. Here, a microfluidics-based approach is ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2020.05.024

    authors: An C,Liu W,Zhang Y,Pang B,Liu H,Zhang Y,Zhang H,Zhang L,Liao H,Ren C,Wang H

    更新日期:2020-07-15 00:00:00

  • Phosphonium-based ionic liquids as modifiers for biomedical grade poly(vinyl chloride).

    abstract::This work reports and discusses the influence of four phosphonium-based ionic liquids (PhILs), namely trihexyl(tetradecyl) phosphonium dicyanamide, [P(6,6,6,14)][dca]; trihexyl(tetradecyl) phosphonium bis(trifluoromethylsulfonyl)imide, [P(6,6,6,14)][Tf(2)N]; tetrabutyl phosphonium bromide, [P(4,4,4,4)][Br]; and tetrab...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2011.10.034

    authors: Dias AM,Marceneiro S,Braga ME,Coelho JF,Ferreira AG,Simões PN,Veiga HI,Tomé LC,Marrucho IM,Esperança JM,Matias AA,Duarte CM,Rebelo LP,de Sousa HC

    更新日期:2012-03-01 00:00:00

  • Predicting and understanding collagen remodeling in human native heart valves during early development.

    abstract::The hemodynamic functionality of heart valves strongly depends on the distribution of collagen fibers, which are their main load-bearing constituents. It is known that collagen networks remodel in response to mechanical stimuli. Yet, the complex interplay between external load and collagen remodeling is poorly underst...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2018.08.040

    authors: Ristori T,Bouten CVC,Baaijens FPT,Loerakker S

    更新日期:2018-10-15 00:00:00

  • An overview of thin film nitinol endovascular devices.

    abstract::Thin film nitinol has unique mechanical properties (e.g., superelasticity), excellent biocompatibility, and ultra-smooth surface, as well as shape memory behavior. All these features along with its low-profile physical dimension (i.e., a few micrometers thick) make this material an ideal candidate in developing low-pr...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审

    doi:10.1016/j.actbio.2015.03.025

    authors: Shayan M,Chun Y

    更新日期:2015-07-01 00:00:00

  • A flexible porous chiral auxetic tracheal stent with ciliated epithelium.

    abstract::Tracheal stent placement is a principal treatment for tracheobronchial stenosis, but complications such as mucus plugging, secondary stenosis, migration, and strong foreign body sensation remain unavoidable challenges. In this study, we designed a flexible porous chiral tracheal stent intended to reduce or overcome th...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2021.01.044

    authors: Liu J,Yao X,Wang Z,Ye J,Luan C,He Y,Lin H,Fu J

    更新日期:2021-01-30 00:00:00

  • Synthesis, characterization and osteoblastic activity of polycaprolactone nanofibers coated with biomimetic calcium phosphate.

    abstract::Immersion of electrospun polycaprolactone (PCL) nanofiber mats in calcium phosphate solutions similar to simulated body fluid resulted in deposition of biomimetic calcium phosphate layer on the nanofibers and thus a highly bioactive novel scaffold has been developed for bone tissue engineering. Coatings with adequate ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2009.04.037

    authors: Mavis B,Demirtaş TT,Gümüşderelioğlu M,Gündüz G,Colak U

    更新日期:2009-10-01 00:00:00

  • Synergistic effects of laminin-1 peptides, VEGF and FGF9 on salivary gland regeneration.

    abstract::Hyposalivation is associated with radiation therapy, Sjögren's syndrome and/or aging, and is a significant clinical problem that decreases oral health and overall health in many patients and currently lacks effective treatment. Hence, methods to regenerate salivary glands and restore saliva secretion are urgently need...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2019.04.049

    authors: Nam K,Dean SM,Brown CT,Smith RJ Jr,Lei P,Andreadis ST,Baker OJ

    更新日期:2019-06-01 00:00:00

  • Cell spreading correlates with calculated logP of amino acid-modified surfaces.

    abstract::The interactions of cells with synthetic surfaces are a critical factor in biomaterials design and it would be invaluable if these interactions could be precisely controlled and predicted. Hydrophobicity or lipophilicity of the surface is commonly used to rationalize cell attachment to materials. In the pharmaceutical...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2007.02.006

    authors: Rawsterne RE,Todd SJ,Gough JE,Farrar D,Rutten FJ,Alexander MR,Ulijn RV

    更新日期:2007-09-01 00:00:00

  • Inkjet printed antibiotic- and calcium-eluting bioresorbable nanocomposite micropatterns for orthopedic implants.

    abstract::Inkjet printing of antibiotic- and calcium-eluting micropatterns was explored as a novel means of preventing the formation of biofilm colonies and facilitating osteogenic cell development on orthopedic implant surfaces. The micropatterns consisted of a periodic array of ∼50 μm circular dots separated by ∼150 μm. The c...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2011.08.006

    authors: Gu Y,Chen X,Lee JH,Monteiro DA,Wang H,Lee WY

    更新日期:2012-01-01 00:00:00

  • A PEGylated fibrin-based wound dressing with antimicrobial and angiogenic activity.

    abstract::Wounds sustained under battlefield conditions are considered to be contaminated and their initial treatment should focus on decreasing this contamination and thus reducing the possibility of infection. The early and aggressive administration of antimicrobial treatment starting with intervention on the battlefield has ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2011.04.003

    authors: Seetharaman S,Natesan S,Stowers RS,Mullens C,Baer DG,Suggs LJ,Christy RJ

    更新日期:2011-07-01 00:00:00

  • Energy dispersive X-ray diffraction study of phase development during hardening of calcium phosphate bone cements with addition of chitosan.

    abstract::The aim of this work was to study the phase transformation during the setting reaction of two calcium phosphate bone cements based on either alpha tricalcium phosphate (alpha-TCP) or tetracalcium phosphate (TetCP) initial solid phase, and a magnesium carbonate-phosphoric acid solution as the hardening liquid. Low mole...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2008.01.006

    authors: Rau JV,Generosi A,Smirnov VV,Ferro D,Rossi Albertini V,Barinov SM

    更新日期:2008-07-01 00:00:00

  • Hypoxia-mimicking Co doped TiO2 microporous coating on titanium with enhanced angiogenic and osteogenic activities.

    abstract:UNLABELLED:Advanced titanium (Ti) based bone implant with both angiogenesis and osteogenesis stimulating activities for enhanced clinical performance is stringently needed. In the present work, TiO2/calcium-phosphate (TCP) coatings on Ti doped with cobalt (Co) of various amounts (designated as C2-TCP, C7-TCP, and C13-T...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.07.045

    authors: Zhou J,Zhao L

    更新日期:2016-10-01 00:00:00

  • Harnessing Wharton's jelly stem cell differentiation into bone-like nodule on calcium phosphate substrate without osteoinductive factors.

    abstract::An important aim of bone regenerative medicine is to design biomaterials with controlled chemical and topographical features to guide stem cell fate towards osteoblasts without addition of specific osteogenic factors. Herein, we find that sprayed bioactive and biocompatible calcium phosphate substrates (CaP) with cont...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.11.042

    authors: Mechiche Alami S,Rammal H,Boulagnon-Rombi C,Velard F,Lazar F,Drevet R,Laurent Maquin D,Gangloff SC,Hemmerlé J,Voegel JC,Francius G,Schaaf P,Boulmedais F,Kerdjoudj H

    更新日期:2017-02-01 00:00:00

  • Enzyme-mediated cross-linking of Pluronic copolymer micelles for injectable and in situ forming hydrogels.

    abstract::A new class of injectable and erodible hydrogels exhibiting highly robust gel strength at body temperature was fabricated by enzyme-mediated cross-linking between Pluronic copolymer micelles. Tyramine-conjugated Pluronic F-127 tri-block copolymers at two terminal ends of polyethylene oxide (PEO) side chains were synth...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2010.11.029

    authors: Lee SH,Lee Y,Lee SW,Ji HY,Lee JH,Lee DS,Park TG

    更新日期:2011-04-01 00:00:00