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Study and evaluation of mechanisms of dual targeting drug delivery system with tumor microenvironment assays compared with normal assays.

Abstract：

:A dual targeting delivery system was developed to completely conquer the two barriers that glioma treatment faces: the blood-brain barrier (BBB) and the brain-glioma barrier. Recently, a system comprising AS1411 aptamer (for glioma targeting) and TGN peptide (for BBB targeting) modified nanoparticles (AsTNPs) was developed, which can effectively target brain glioma and improve the survival of glioma-bearing mice. However, the in vitro models currently used are far too different from the in vivo tumor microenvironment that the glioma targeting delivery system actually faces. In this study, the pharmacology mechanisms of AsTNPs were explored in several models that imitated the tumor microenvironment. AsTNPs can be selectively taken up by endothelial and glioma cells, effectively penetrating the BBB and brain-glioma barriers to reach glioma cells and display their anti-glioma effect. The cell monolayers, tumor spheroids and coculture systems were more suitable in vitro models for the pharmacology evaluation of targeted drug delivery systems.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Gao H,Yang Z,Zhang S,Pang Z,Liu Q,Jiang X

doi

10.1016/j.actbio.2013.11.003

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

858-67

issue

2

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(13)00559-X

journal_volume

10

pub_type

杂志文章

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