Abstract:
PURPOSE:The purpose of the present study is to apply kinetic analysis to investigate exercise-related changes in the metabolism of the skeletal muscle of the rat hindlimb by [[Formula: see text]]acetate positron emission tomography and computed tomography (PET/CT). METHODS:Contractions were induced in Wistar rats' left hindlimb by electrostimulation of the Vastus Lateralis muscle motor point. After 15 min of muscle contractions, [[Formula: see text]]acetate was injected and PET/CT of both hindlimbs was acquired. The resting hindlimb was used as a control reference. The kinetic parameters [Formula: see text] and [Formula: see text] were calculated for the target muscles (exercised and control) and correlated with the corresponding standardized uptake values (SUVs). The ratio between each kinetic parameter values and the SUV extracted for the exercised muscle and the muscle at rest was computed ([Formula: see text] and [Formula: see text], respectively). RESULTS:Kinetic analysis quantitatively confirmed that net tracer uptake ([Formula: see text]) and washout ([Formula: see text]) were significantly higher in exercised muscles ([Formula: see text] for exercised muscles vs. [Formula: see text] for resting muscles, [Formula: see text]; [Formula: see text] for exercised muscle vs. [Formula: see text] for resting muscle, [Formula: see text]). On the other hand, SUV was not significantly different between active and inactive muscles ([Formula: see text] for exercised muscles vs. [Formula: see text] for resting muscles). Linear regression analysis revealed a good correlation ([Formula: see text]) between net tracer uptake ratio ([Formula: see text]) and the SUV ratio [Formula: see text]). A lower correlation was found between the net tracer washout ratio ([Formula: see text]) and the SUV ratio ([Formula: see text]). CONCLUSION:The present study showed that kinetic modelling can detect changes between active and inactive skeletal muscles with a higher sensitivity with respect to the SUV, when performed with [[Formula: see text]]acetate PET/CT.
journal_name
Int J Comput Assist Radiol Surgauthors
Trombella S,García D,Colin DJ,Germain S,Seimbille Y,Ratib Odoi
10.1007/s11548-015-1260-8subject
Has Abstractpub_date
2016-05-01 00:00:00pages
733-43issue
5eissn
1861-6410issn
1861-6429pii
10.1007/s11548-015-1260-8journal_volume
11pub_type
杂志文章abstract:PURPOSE:Ultrasound is increasingly being employed in different orthopedic procedures as an imaging modality for real-time guidance. Nevertheless, low signal-to-noise-ratio and different imaging artifacts continue to hamper the success of ultrasound-based procedures. Bone shadow region is an important feature indicating...
journal_title:International journal of computer assisted radiology and surgery
pub_type: 杂志文章
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journal_title:International journal of computer assisted radiology and surgery
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:International journal of computer assisted radiology and surgery
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:International journal of computer assisted radiology and surgery
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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journal_title:International journal of computer assisted radiology and surgery
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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更新日期:2019-08-01 00:00:00
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journal_title:International journal of computer assisted radiology and surgery
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journal_title:International journal of computer assisted radiology and surgery
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更新日期:2014-05-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2016-04-01 00:00:00
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journal_title:International journal of computer assisted radiology and surgery
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更新日期:2019-03-01 00:00:00
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更新日期:2018-11-01 00:00:00
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journal_title:International journal of computer assisted radiology and surgery
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更新日期:2010-07-01 00:00:00
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journal_title:International journal of computer assisted radiology and surgery
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journal_title:International journal of computer assisted radiology and surgery
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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更新日期:2018-05-01 00:00:00
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journal_title:International journal of computer assisted radiology and surgery
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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更新日期:2020-02-01 00:00:00