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Comparison of the application of B-mode and strain elastography ultrasound in the estimation of lymph node metastasis of papillary thyroid carcinoma based on a radiomics approach.

Abstract：

PURPOSE:B-mode ultrasound (B-US) and strain elastography ultrasound (SE-US) images have a potential to distinguish thyroid tumor with different lymph node (LN) status. The purpose of our study is to investigate whether the application of multi-modality images including B-US and SE-US can improve the discriminability of thyroid tumor with LN metastasis based on a radiomics approach. METHODS:Ultrasound (US) images including B-US and SE-US images of 75 papillary thyroid carcinoma (PTC) cases were retrospectively collected. A radiomics approach was developed in this study to estimate LNs status of PTC patients. The approach included image segmentation, quantitative feature extraction, feature selection and classification. Three feature sets were extracted from B-US, SE-US, and multi-modality containing B-US and SE-US. They were used to evaluate the contribution of different modalities. A total of 684 radiomics features have been extracted in our study. We used sparse representation coefficient-based feature selection method with 10-bootstrap to reduce the dimension of feature sets. Support vector machine with leave-one-out cross-validation was used to build the model for estimating LN status. RESULTS:Using features extracted from both B-US and SE-US, the radiomics-based model produced an area under the receiver operating characteristic curve (AUC) [Formula: see text] 0.90, accuracy (ACC) [Formula: see text] 0.85, sensitivity (SENS) [Formula: see text] 0.77 and specificity (SPEC) [Formula: see text] 0.88, which was better than using features extracted from B-US or SE-US separately. CONCLUSIONS:Multi-modality images provided more information in radiomics study. Combining use of B-US and SE-US could improve the LN metastasis estimation accuracy for PTC patients.

journal_name

Int J Comput Assist Radiol Surg

journal_title

International journal of computer assisted radiology and surgery

authors

Liu T,Ge X,Yu J,Guo Y,Wang Y,Wang W,Cui L

doi

10.1007/s11548-018-1796-5

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1617-1627

issue

eissn

1861-6410

issn

1861-6429

pii

10.1007/s11548-018-1796-5

journal_volume

pub_type

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Comparison of the application of B-mode and strain elastography ultrasound in the estimation of lymph node metastasis of papillary thyroid carcinoma based on a radiomics approach.