Characterization of LipN (Rv2970c) of Mycobacterium Tuberculosis H37Rv and its Probable Role in Xenobiotic Degradation.

abstract：:Angiotensin converting enzyme (ACE) 2 is a carboxypeptidase that shares 42% amino acid homology with ACE. Little is known about the regulation or pattern of expression of ACE2 in the mouse lung, including its definitive cellular distribution or developmental changes. Based on Northern blot and RT-PCR data, we report t...

journal_title：Journal of cellular biochemistry

authors： Wiener RS,Cao YX,Hinds A,Ramirez MI,Williams MC

更新日期：2007-08-01 00:00:00

abstract：:We have recently demonstrated that transforming growth factor (TGF)-beta 1 and TGF-beta 2 are potent inhibitors of the growth and differentiation of murine and human hematopoietic cells. The proliferation of primary unfractionated murine bone marrow by interleukin-3 (IL-3) and human bone marrow by IL-3 or granulocyte/...

journal_title：Journal of cellular biochemistry

authors： Keller JR,Sing GK,Ellingsworth LR,Ruscetti FW

更新日期：1989-02-01 00:00:00

abstract：:Butyrate inhibits growth of lung cancer. However, the molecular mechanism is still unclear. Here we profiled miRNAs that responded to sodium butyrate(NaB) stimulation in A549 cells, a non-small cell lung cancer cell line, using microarray. We found 33 up-regulated microRNAs and 22 down-regulated microRNAs (log2 ≥1.5 f...

journal_title：Journal of cellular biochemistry

authors： Xiao X,Cao Y,Chen H

更新日期：2018-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the development and progression of non-small cell lung cancer (NSCLC). Recently, several studies have shown that miR-99a is downregulated in various cancers, which can affect tumor initiation and maintenance. Herein, we found that miR-99a was downregulated in NSCLC tissues ...

journal_title：Journal of cellular biochemistry

authors： Yu SH,Zhang CL,Dong FS,Zhang YM

更新日期：2015-02-01 00:00:00

abstract：:Phosphoinositides (PIs) and proteins involved in the PI signaling pathway are distributed in the nucleus as well as at the plasma membrane and in the cytoplasm, although their nuclear localization mechanisms have not been clarified in detail. Generally, proteins that shuttle between the cytoplasm and nucleus contain n...

journal_title：Journal of cellular biochemistry

authors： Yagisawa H

更新日期：2006-02-01 00:00:00

abstract：:Sea urchin CS histone variants are electrophoretically heterogeneous when analyzed in two dimensional polyacrylamide gels (2D-PAGE). Previous results suggested that this heterogeneity is due to the poly (ADP-ribosylation) of these proteins. Consequently, native CS histone variants were subjected to different treatment...

journal_title：Journal of cellular biochemistry

authors： Imschenetzky M,Morín V,Carvajal N,Montecino M,Puchi M

更新日期：1996-04-01 00:00:00

abstract：:The expression of matrix metalloproteinase-13 (MMP-13), involved in bone turnover, is elevated in stretched MC3T3-E1 osteoblast-like cells. Strain-mediated forces impact bone remodeling due in large part to the movement of fluid through the canalicular-lacunar network. The resulting fluid shear stress (FSS) over the s...

journal_title：Journal of cellular biochemistry

authors： Charoonpatrapong-Panyayong K,Shah R,Yang J,Alvarez M,Pavalko FM,Gerard-O'Riley R,Robling AG,Templeton E,Bidwell JP

更新日期：2007-12-01 00:00:00

abstract：:Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. It may lead to neurodevelopmental impairment and adulthood onset disorders. Recently, long noncoding RNAs (lncRNAs) were found to be associated with the pathogenesis of FGR. Here we report th...

journal_title：Journal of cellular biochemistry

authors： Zhang L,Deng X,Shi X,Dong X

更新日期：2019-06-01 00:00:00

abstract：:Osteoporosis and its complications cause morbidity and mortality in the aging population, and result from increased bone resorption by osteoclasts in parallel with decreased bone formation by osteoblasts. A widely accepted strategy for improving bone health is targeting osteoprogenitor cells in order to stimulate thei...

journal_title：Journal of cellular biochemistry

authors： Amantea CM,Kim WK,Meliton V,Tetradis S,Parhami F

更新日期：2008-10-01 00:00:00

abstract：:Skin is a representative self-renewing tissue containing stem cells. Although many attempts have been made to define and isolate skin-derived stem cells, establishment of a simple and reliable isolation procedure remains a goal to be achieved. Here, we report the isolation of cells having stem cell properties from mou...

journal_title：Journal of cellular biochemistry

authors： Medina RJ,Kataoka K,Takaishi M,Miyazaki M,Huh NH

更新日期：2006-05-01 00:00:00

abstract：:HOXB13 exerts a close relation in several human cancers. This study explored the role of HOXB13 in glioblastoma (GBM), a brain tissue with the highest aggressive rate and mortality in adults. Through microarray and immunohistochemistry analyses, HOXB13 was highly expressed in GBM tissues. Furthermore, we showed that h...

journal_title：Journal of cellular biochemistry

authors： Wang X,Sun Y,Xu T,Qian K,Huang B,Zhang K,Song Z,Qian T,Shi J,Li L

更新日期：2019-09-01 00:00:00

abstract：:Metastatic cancer is a complex positive feedback loop system. Such as system has a tendency to acquire extreme robustness. Signaling pathways controlling that robustness can fail completely if an essential element from the signaling is removed. That element is a locus of fragility. Targeting that locus represents the ...

journal_title：Journal of cellular biochemistry

authors： Radisavljevic Z

更新日期：2008-08-15 00:00:00

abstract：:We investigated the effects of vitamin D3 on the signaling pathways by prostaglandin E2 (PGE2) in osteoblast-like MC3T3-E1 cells. The pretreatment with 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), an active form of vitamin D3, significantly inhibited cAMP accumulation induced by 10 microM PGE2 in a dose-dependent manner i...

journal_title：Journal of cellular biochemistry

authors： Tokuda H,Kotoyori J,Suzuki A,Oiso Y,Kozawa O

更新日期：1993-06-01 00:00:00

abstract：:Every year about 500,000 people in the United States die as a result of cancer. Among them, 90% exhibit systemic disease with metastasis. Considering this high rate of incidence and mortality, it is critical to understand the mechanisms behind metastasis and identify new targets for therapy. In recent years, two broad...

journal_title：Journal of cellular biochemistry

authors： Tse JC,Kalluri R

更新日期：2007-07-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) infects millions of people each year. These bacilli can survive inside macrophages. To favor their survival, pathogen alters various signal transduction pathways in host cells. Phospholipase C (PLC) signaling regulates various processes in mammalian cells but has never been investigate...

journal_title：Journal of cellular biochemistry

authors： Paroha R,Chaurasiya SK,Chourasia R

更新日期：2019-04-01 00:00:00

abstract：:The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of ...

journal_title：Journal of cellular biochemistry

authors： Stein GS,Zaidi SK,Stein JL,Lian JB,van Wijnen AJ,Montecino M,Young DW,Javed A,Pratap J,Choi JY,Ali SA,Pande S,Hassan MQ

更新日期：2008-08-15 00:00:00

abstract：:Cutaneous melanoma (CM) has become a major public health concern. Studies illustrate that minichromosome maintenance protein 7 (MCM7) participate in various diseases including skin disease. Our study aimed to study the effects of MCM7 silencing on CM cell autophagy and apoptosis by modulating the AKT threonine kinase ...

journal_title：Journal of cellular biochemistry

authors： Yang Y,Ma S,Ye Z,Zhou X

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is a progressive and disabling disorder, characterized by synovial inflammation and joint effusion. This study aimed to explore the role of stanniocalcin-1 (STC1) in the development of OA by regulating the survival and inflammation of fibroblast-like synovial (FLS) cells. METHODS:Microarr...

journal_title：Journal of cellular biochemistry

authors： Wu Y,Li Z,Jia W,Li M,Tang M

更新日期：2019-06-01 00:00:00

abstract：:Preserving self-renewal, multipotent capacity, and large-scale expansion of highly functional progenitor cells, including endothelial progenitor cells (EPCs), is a controversial issue. These current limitations, therefore, raise the need of developing promising in vitro conditions for prolonged expansion of EPCs witho...

journal_title：Journal of cellular biochemistry

authors： Siavashi V,Nassiri SM,Rahbarghazi R,Vafaei R,Sariri R

更新日期：2016-08-01 00:00:00

abstract：:The myelin basic protein (MBP)-phosphorylating enzymes present during maturation and early embryogenesis of the sea star (Pisaster ochraceus) were investigated. The major maturation-activated MBP kinase (p45 Mapk) was molecularly cloned based on tryptic sequence information obtained with the purified enzyme and shown ...

journal_title：Journal of cellular biochemistry

authors： Lefebvre DL,Charest DL,Yee A,Crawford BJ,Pelech SL

更新日期：1999-11-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinical emergencies with no effective pharmaceutical treatment. This study aims to determine the protective effects of Nrf2-transfected human amniotic mesenchymal stem cells (hAMSCs) against lipopolysaccharide (LPS)-induced lung injury in mice...

journal_title：Journal of cellular biochemistry

authors： Zhang S,Jiang W,Ma L,Liu Y,Zhang X,Wang S

更新日期：2018-02-01 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95-2). Sorafenib induced cell death in EC cell...

journal_title：Journal of cellular biochemistry

authors： Sun NK,Huang SL,Chang TC,Chao CC

更新日期：2013-08-01 00:00:00

abstract：:Gastric cancer (GC) is the fifth most frequent cancer and the third-leading cause of cancer-related death worldwide. It is a highly heterogeneous disease regarding the morphological and molecular viewpoints. Since it is curable in primary stages, early detection could improve the survival rate. Long noncoding RNAs con...

journal_title：Journal of cellular biochemistry

authors： Kangarlouei R,Irani S,Noormohammadi Z,Memari F,Mirfakhraie R

更新日期：2019-08-01 00:00:00

abstract：:We previously suggested that keratinocyte releasable factors might modulate the wound healing process by regulating the expression of key extracellular matrix components such as collagenase (matrix metalloproteinase-1) and type I collagen in fibroblasts. The first one, we called it keratinocyte-derived anti-fibrogenic...

journal_title：Journal of cellular biochemistry

authors： Chavez-Muñoz C,Hartwell R,Jalili RB,Jafarnejad SM,Lai A,Nabai L,Ghaffari A,Hojabrpour P,Kanaan N,Duronio V,Guns E,Cherkasov A,Ghahary A

更新日期：2012-08-01 00:00:00

abstract：:Promyelocytic leukemia nuclear bodies (PML-NBs) are multiprotein complexes that include PML protein and localize in nuclear foci. PML-NBs are implicated in multiple stress responses, including apoptosis, DNA repair, and p53-dependent growth inhibition. ALT-associated PML bodies (APBs) are specialized PML-NBs that incl...

journal_title：Journal of cellular biochemistry

authors： Shen H,Maki CG

更新日期：2010-12-01 00:00:00

abstract：:As an aggressive breast cancer (BCa) subtype, triple-negative breast cancer (TNBC) responses poorly to chemotherapy and endocrine therapy, and usually has a worse prognosis. This is largely due to the lack of specific therapeutic targets, laying claim to an imperious demand to clarify the key signaling pathways potent...

journal_title：Journal of cellular biochemistry

authors： Tang X,Zhou Y,Liu Y,Zhang W,Liu C,Yan C

更新日期：2020-11-01 00:00:00

abstract：:Genistein, a natural isoflavone phytoestrogen present in soybeans, caused a dose-dependent growth inhibition of the two hormone-sensitive cell lines T47D and ZR75.1 and of the two hormone-independent cell lines MDAMB-231 and BT20. Flow cytometric analysis of cells treated for 4 days with 15 and 30 microM genistein sho...

journal_title：Journal of cellular biochemistry

authors： Cappelletti V,Fioravanti L,Miodini P,Di Fronzo G

更新日期：2000-09-14 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) expression and the growth factor such as platelet-derived growth factor (PDGF) and their receptors have been considered relevant in the process of angiogenesis and dissemination in esophageal squamous cell carcinoma (ESCC). Small glutamine-rich tetratricopeptide repeat-containing prote...

journal_title：Journal of cellular biochemistry

authors： Yang X,Cheng L,Li M,Shi H,Ren H,Ding Z,Liu F,Wang Y,Cheng C

更新日期：2014-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is known as one of important autoimmune disorders which can lead to joint pain and damage throughout body. Given that internal (ie, genetic and epigenetic alterations) and external factors (ie, lifestyle changes, age, hormones, smoking, stress, and obesity) involved in RA pathogenesis. Increa...

journal_title：Journal of cellular biochemistry

authors： Zakeri Z,Salmaninejad A,Hosseini N,Shahbakhsh Y,Fadaee E,Shahrzad MK,Fadaei S

更新日期：2019-03-01 00:00:00

abstract：:Diacylglycerol (DG) kinase (DGK), which phosphorylates DG to generate phosphatidic acid (PA), consists of ten isozymes (α-к). Recently, we identified a novel small molecule inhibitor, CU-3, that selectively inhibits the activity of the α isozyme. In addition, we newly obtained Compound A, which selectively and strongl...

journal_title：Journal of cellular biochemistry

authors： Yamaki A,Akiyama R,Murakami C,Takao S,Murakami Y,Mizuno S,Takahashi D,Kado S,Taketomi A,Shirai Y,Goto K,Sakane F

更新日期：2019-06-01 00:00:00