Abstract：
BACKGROUND:Acute appendicitis is one of the most common surgical emergencies. An early and accurate diagnosis of acute appendicitis is vital. Evidence for a link between platelets indices and inflammation disease comes from recent studies. We aimed to evaluate preoperative diagnostic values of platelet indices (Mean platelet volume-MPV, Platelet Distribution Width-PDW, Plateletcrit-PCT) and leukocyte count (WBC) in comparison with post-operative histopathology results in patients who underwent appendectomy. METHODS:The 165 patients who underwent appendectomy, were evaluated retrospectively. Patients' demographic characteristics, imaging findings, preoperative laboratory markers and postoperative histopathology results were recorded. The patients were divided into three groups based on the histopathologic findings; perforated appendicitis, acute appendicitis without perforation and negative appendectomy group. The specificity, sensitivity, positive predictive value (PPV) and negative predictive value (NPV) of the laboratory markers were measured. Additionally potential correlation among laboratory markers analysed. RESULTS:The negative appendectomy rate was 15.1% in 165 patients. The leukocyte count was statistically higher in acute appendicitis (14.9×103/μL) group than negative appendectomy (6.9×103/μL) group. There was also statistically significant difference between groups according to the PCT levels. The leukocyte count achieved sensitivity, specificity, PPV, and NPV of 95.9, 24, 99.1, and 92.7% respectively. A significant positive correlation between WBC and PCT were obtained. Inflammatory markers were not directly related to the severity of the disease. CONCLUSIONS:Elevated leukocyte count and PCT levels support diagnosis of acute appendicitis in correlation with pathological findings. Thereby combination of the inflammatory markers, positive clinical and radiological findings would improve diagnostic accuracy in acute appendicitis. KEY WORDS:Acute appendicitis, Inflammatory markers, Platelet indices. :L’appendicite acuta è una delle più comuni emergenze chirurgiche, ed una sua diagnosi tempestiva e precisa è della massima importanza. Da studi recenti è emerso un evidente colllegamento tra gli indici piastrinici e le malattie infiammatorie. Con questo studio ci siamo proposti di valutare il valore diagnostico preoperatorio degli indici piastrinici (volume piastrinico medio – MPV, distribuzione dello spessore piastrinico – PDW, piatrinocrito – PCT) e conta leucocitaria (WBC) in raffronto con i dati istopatologici postopertaori in pazienti sottoposti ad appendicectomia. Lo studio è stato condotto su 165 pazienti appendicectomizzati, e valutati retrospettivamente, rilevando le loro caratteristiche demografiche, la diagnostica per immagini ed i dati di laboratorio preoperatori ed i risultati istopatologici postoperatori. I pazienti sono stati suddivisi in tre gruppi in relazione ai rilievi istopatologici: appendicite perforata, appendicite acuta senza perforazione e appendice indenne. Sono stati presi in considerazione specificità, sensibilità e valore predittivo positivo (PPV) e negativo (NPV) dei dati di laboratorio, analizzando ulteriori correlazioni potenziali tra questi dati. L’incidenza delle appendicectomie con appendice indenne è risultata del 15,1% sui 165 pazienti. La conta leucocitaria è risultata statisticamente più elevata nel gruppo delle appendiciti acute (14,9 x 103/μL ) rispetto al gruppo delle appendici indenni (6.9×103/μL). Sono risultate differenze statisticamente significative tra i gruppi in relazione ai livelli del piastrinocrito. La conta leucocitaria ha dimostrato sensibilità, specificità, PPV e NPV rispettivamente del 95,9%, 24%, 99,1% e 92,7% ed una correlazione positiva tra WBC e PCT senza una diretta correlazione tra i markers della flogosi e la sua gravità In conclusione una conta leucocitaria elevata ed alti livelli del PCT sono diagnostici nell’appendicite acuta in correlazione con i dati isto-patologici. Pertanto la combinazione dei markers infiammatori con i reperti clinici e radiologici sono in grado di migliorare l’accuratezza diagnostica nell’appendicite acuta.
journal_name
Ann Ital Chirjournal_title
Annali italiani di chirurgiaauthors
Gu Nes ME,Deniz MM,Yılmaz Ssubject
Has Abstractpub_date
2017-01-01 00:00:00pages
222-228eissn
0003-469Xissn
2239-253Xpii
S0003469X17027191journal_volume
88pub_type
杂志文章abstract：:Gastric hyperplastic polyps are often asymptomatic and are found incidentally at upper endoscopy performed for unrelated reasons. Although they are considered a benign lesion, all symptomatic polyps should be removed for a more reliable histological diagnosis, resolution of symptoms and to prevent potential malignant ...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：AIM OF THE STUDY:The superior pedicle mammaplasty is a technique frequently employed in the treatment of breast ptosis, associated or not with hypertrophy of the gland, followed by satisfactory results. This technique is normally not indicated in severe breast ptosis (pendulous breast) because of the excessive length o...
journal_title：Annali italiani di chirurgia
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更新日期：2007-11-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:An increase in intra-abdominal pressure causes a decrease in the splanchnic blood flow and the intramucosal pH of the bowel, as well as increasing the risk of ischemia in the colon. The aim of the present study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on the ischemia caused by laparoscop...
journal_title：Annali italiani di chirurgia
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更新日期：2016-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
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doi：
更新日期：2006-11-01 00:00:00
abstract：:Venous leg ulcer is the most frequent cause of trophic lesions of the limbs in patients with chronic venous insufficiency. Appropriate management of cutaneous vascular lesions is based on systemic, vascular and local assessment. The Authors used a protease-modulating matrix in 126 patients suffering from venous leg ul...
journal_title：Annali italiani di chirurgia
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doi：
更新日期：2009-09-01 00:00:00
abstract：AIM:The aim of our study was to determine how many and what subtypes of breast cancer could be treated with breast-conserving surgery after NACT. Another outcome was to determine the applicability of MD Anderson Cancer Center nomogram to predict it. MATERIAL OF STUDY:We reviewed the histological examinations of 86 per...
journal_title：Annali italiani di chirurgia
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更新日期：2018-01-01 00:00:00
abstract：:The early rectal cancer which needs conservative surgical treatment should present some pathological characters: intramucosal site without muscularis invasion (pT1), high or moderate differentiated grading (GI-G2), no lymph node metastasis or vascular invasion. Total mesorectal excision is the gold standard for these ...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：2003-05-01 00:00:00
abstract：AIM:To value the results of "open" surgery with sphincter preservation, TME nerve-sparing, fast-track, without a protective stoma in a consecutive series of patients with subperitoneal rectal cancer (s.p.r.c.). MATERIALS AND METHODS:In January 1989, we started a prospective, non-randomized study designed to assess whe...
journal_title：Annali italiani di chirurgia
pub_type： 临床试验,杂志文章
doi：
更新日期：2010-07-01 00:00:00
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journal_title：Annali italiani di chirurgia
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doi：
更新日期：1989-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
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doi：
更新日期：2012-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:"Forgotten" goiter is an extremely rare disease which is defined as a mediastinal thyroid mass found after total thyroidectomy. The authors report their experience of 7 cases of residual mediastinal goiter after total thyroidectomy for substernal goiter. Six patients were female and one male with a median age of 56 ye...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:A correlation between the location of mutation in the adenomatous polyposis coli (APC) gene and clinical manifestations of familial adenomatous polyposis (FAP) has repeatedly been reported. Some Authors suggest the use of mutational analysis as a guide to select the best surgical option in FAP patients. Howe...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:A dissection of a manometric trace of the upper esophageal sphincter and the crico-esophageal coordination Although manometry is the most accurate method for diagnosing esophageal motility disorders, several patient suffering of high dysphagia remain undiagnosed. Most Authors concentrate their efforts in studying the ...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：2007-09-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:In spite of the decreasing incidence of gastric carcinoma, as it is reported in recent reports from the U.S.A., total gastrectomy and its surgical indications results and complications, focus the interest of surgeons. We analize 61 cases of total gastrectomy for carcinoma, treated in the years 1982-1992. Perioperative...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：INTRODUCTION:We report a case of correction of an end colostomy prolapse with Delorme technique in an advanced stage oncologic patient to emphasize the clinical implications and advantages of this procedure. CASE REPORT:A 51-year-old male patient with a stage IV rectal adenocarcinoma underwent laparoscopy for a pallia...
journal_title：Annali italiani di chirurgia
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doi：
更新日期：2012-11-01 00:00:00
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journal_title：Annali italiani di chirurgia
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doi：
更新日期：2002-05-01 00:00:00
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journal_title：Annali italiani di chirurgia
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doi：
更新日期：1999-09-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2008-05-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：UNLABELLED:Ectopic thyroid goiter accounts approximately for 1% of all substernal goiters and for 10-15% of all mediastinal masses. Sternotomy is generally accepted as the most adequate approach for the removal of ectopic thyroid goiters of the anterior mediastinum. We report two cases of mediastinal ectopic goiter rem...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
