The role of nuclear medicine in the management of thymomas.

Abstract:

AIM OF THE STUDY:To evaluate the role of nuclear medicine techniques in the management of patients with thymoma. MATERIALS AND METHODS:The Authors performed a review of the literature about the usefulness of traditional nuclear medicine and positron emission tomography in patients with thymic tumours. RESULTS AND DISCUSSION:Nuclear medicine imaging can provide additional information in cases of thymoma such as in differential diagnosis between thymic tumours, staging and restaging. Thallium-201 (201Tl), 99mTc-sestamibi and 99mTc-tetrofosmin are useful tumour-imaging agent. Another radiopharmaceutical useful in the management of thymomas is 111In-pentetreotide, a somatostatin analogue, used to define the receptor status and the extent of disease in malignant thymomas. Positron emission tomography (PET) is a powerful diagnostic tool for diagnosis, staging and restaging of neoplasms in general. The most used PET radiopharmaceutical is the fluorodeoxyglucose (18F-FDG), a glucose analogue. The uptake of FDG reflects the metabolic activity of organs and neoplasms and correlates with the tumour growth rate. There is a paucity of literature on the use of PET scanning in the diagnosis of thymoma. Further perspective studies with a larger number of cases, considering the development of hybrid imaging PET-CT and new PET radiopharmaceuticals, may increase the role of nuclear medicine in the diagnostic and therapeutic management of thymic neoplasms.

journal_name

Ann Ital Chir

authors

Treglia G,Spitilli MG,Calcagni ML,Giordano A

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

371-4

issue

5

eissn

0003-469X

issn

2239-253X

journal_volume

78

pub_type

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