Pancuronium and vecuronium pharmacokinetics and pharmacodynamics in younger and elderly adults.

abstract：BACKGROUND:Previously, the authors found that anesthetized diabetic dogs had increased cerebral blood flow (CBF) and oxygen consumption (CMRO2). These results may have been influenced by anesthesia or surgery. The aim of this study was to determine whether CBF and CMRO2 are increased in the awake or anesthetized state ...

journal_title：Anesthesiology

authors： Sieber FE,Brown PR,Wu Y,Koehler RC,Traystman RJ

更新日期：1993-11-01 00:00:00

abstract：:The treatment of venous air embolism by aspiration from central venous catheters is well established. However, some anesthesiologists prefer to use a pulmonary artery catheter to monitor patients undergoing a neurosurgical procedure in the sitting position. While offering certain advantages, pulmonary artery catheters...

journal_title：Anesthesiology

authors： Bowdle TA,Artru AA

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of the local anesthetic used or by pretreatment with a beta2-adrenoceptor agonist is unknown. Therefore, we assessed the effect of awake fiberoptic intubation after lidocaine or dyclonin...

journal_title：Anesthesiology

authors： Groeben H,Schlicht M,Stieglitz S,Pavlakovic G,Peters J

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:The health-related effects of the operating room environment are unclear. The authors compared mortality risks of anesthesiologists to those of internal medicine physicians between 1979 and 1995. METHODS:The Physician Master File database, a listing of all US physicians, was used to identify anesthesiologis...

journal_title：Anesthesiology

authors： Alexander BH,Checkoway H,Nagahama SI,Domino KB

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Exogenous pyruvate and ethyl pyruvate (EP), the key ingredient in a new Ringer's solution in clinical trials, are antioxidants as well as metabolic substrates. In vivo studies show both to be protective in oxidative stress, with EP being better. The authors used an acute rat brain slice preparation to compar...

journal_title：Anesthesiology

authors： Zeng J,Liu J,Yang GY,Kelly MJ,James TL,Litt L

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Spinal nitric oxide (NO) is important for the analgesic actions of morphine and cholinergic agents. Its role in the analgesic effect of delta-opioid receptor agonists is not known. In the present study, the authors determined the role of spinal endogenous NO in the antinociceptive effect of intrathecal [D-Pe...

journal_title：Anesthesiology

authors： Chen SR,Pan HL

更新日期：2003-01-01 00:00:00

abstract：:Effects of lidocaine on arterial pressure, heart rate and electrocortical activity were studied in nine fetal lambs at 0.77 to 0.92 gestation (116 to 138 days of gestation; term in sheep is 150 days). Lidocaine was administered into a fetal femoral vein either as a continuous infusion or as a bolus injection. Epilepti...

journal_title：Anesthesiology

authors： Teramo K,Benowitz N,Heymann MA,Rudolph AM

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:In the event of trauma, emergency reversal of anticoagulation therapy may be required. However, no specific reversal agents are routinely available for the direct oral anticoagulants such as dabigatran. The authors investigated four-factor prothrombin complex concentrate (PCC) for treating dabigatran-induced...

journal_title：Anesthesiology

authors： Honickel M,Braunschweig T,van Ryn J,Ten Cate H,Spronk HM,Rossaint R,Grottke O

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Ventilator-associated pneumonia is a clear risk factor for acute lung injury which has been poorly described in trauma patients. This prospective study was undertaken to estimate the incidence of such ventilator-associated pneumonia leading to acute lung injury, the risk factors, and the associated morbidity...

journal_title：Anesthesiology

authors： Stéphan F,Mabrouk N,Decailliot F,Delclaux C,Legrand P

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:This study was conducted to compare the performance accuracy of the independent variables Bispectral Index (BIS), A-Line ARX index (AAI), and predicted propofol effect-site concentration (CePROP) to measure the dependent variables of loss of responses to different stimulation defined as loss of response to v...

journal_title：Anesthesiology

authors： Struys MM,Vereecke H,Moerman A,Jensen EW,Verhaeghen D,De Neve N,Dumortier FJ,Mortier EP

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Memory function under anesthesia is undesired but may arise from light hypnosis as well as stress-enhanced learning during surgery. The bispectral index (BIS, Aspect Medical Systems, Norwood, MA) is a monitor of hypnotic state that can help to avoid light hypnosis (i.e., BIS above 60). This study tested the ...

journal_title：Anesthesiology

authors： Kerssens C,Gaither JR,Sebel PS

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children. METHODS:Eighty unpremedicated c...

journal_title：Anesthesiology

authors： Ved SA,Walden TL,Montana J,Lea DE,Tefft MC,Kataria BK,Pudimat MA,Nicodemus HF,Milmoe GJ

更新日期：1996-07-01 00:00:00

abstract：:The authors investigated the value of high-dose thiopental (TH) therapy after 16-min complete global brain ischemia (GBI) in three groups of pigtailed monkeys, using a neck cuff model of GBI with 96 h intensive care postischemia (PI). Control group (n18): Normotension was restored within 2 min PI; paralysis/controlled...

journal_title：Anesthesiology

authors： Gisvold SE,Safar P,Hendrickx HH,Rao G,Moossy J,Alexander H

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:Evidence concerning the concentrations of volatile anesthetics that prevent learning and recall is limited. Epinephrine is believed to enable learning during anesthesia. We investigated the effects of isoflurane and its interaction with epinephrine on learning and subsequent retention of the rabbit's classic...

journal_title：Anesthesiology

authors： el-Zahaby HM,Ghoneim MM,Johnson GM,Gormezano I

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:The authors compared the intubation success rate of straight reinforced tracheal tubes emerging from the Airtraq laryngoscope (Prodol Meditec S.A., Vizcaya, Spain) with standard preformed polyvinyl chloride tracheal tubes in anesthetized patients. METHODS:The authors randomly allocated 347 adult patients to...

journal_title：Anesthesiology

authors： Dimitriou VK,Zogogiannis ID,Douma AK,Pentilas ND,Liotiri DG,Wachtel MS,Karakitsos D

更新日期：2009-12-01 00:00:00

abstract：:The effect of halothane, at clinically relevant concentrations on the ability of human polymorphonuclear leukocytes (PMNL) to kill the most frequently isolated gram-negative organisms responsible for human bacteremias, Escherichia coli and Klebsiella pneumoniae, was studied. Exposure of PMNL to 0.75 per cent halothane...

journal_title：Anesthesiology

authors： Welch WD

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Aprotinin has been reported to reduce blood loss and transfusion requirements in patients having major orthopedic operations. Data on whether epsilon amino-caproic acid (EACA) is effective in this population are sparse. METHODS:Sixty-nine adults with malignancy scheduled for either pelvic, extremity or spin...

journal_title：Anesthesiology

authors： Amar D,Grant FM,Zhang H,Boland PJ,Leung DH,Healey JA

更新日期：2003-02-01 00:00:00

abstract：:This study was designed to assess the relationship between MAC and hypertension. To this purpose, MAC of halothane was determined in fully inbred spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Because MAC determination was performed in animals whose lungs were mechanically ventilated, the adequacy ...

journal_title：Anesthesiology

authors： Wouters P,Doursout MF,Merin RG,Chelly JE

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Cardiac complications are common during the postoperative period and may be associated with hypoxemia and tachycardia. Preliminary studies in high-risk patients after operation have shown a possible beneficial effect of oxygen therapy on arterial oxygen saturation and heart rate. METHODS:The authors studied...

journal_title：Anesthesiology

authors： Rosenberg-Adamsen S,Lie C,Bernhard A,Kehlet H,Rosenberg J

更新日期：1999-02-01 00:00:00

abstract：:An important guideline for anesthesia in patients with ischemic heart disease is the effect on myocardial oxygen demand. Therefore, this investigation evaluated commonly used myocardial oxygen demand formulas for clinical application. The study was performed on patients undergoing coronary bypass surgery (n = 62). Mea...

journal_title：Anesthesiology

authors： Hoeft A,Sonntag H,Stephan H,Kettler D

更新日期：1991-07-01 00:00:00

abstract：:Carotid endarterectomy requires temporary surgical occlusion of the involved carotid artery. During occlusion, the minimally acceptable (critical) internal carotid artery stump pressure is reported to be 50 torr, whereas for regional cerebral blood flow (rCBF), a critical range is reported to be 18-24 ml/100 g/min. Du...

journal_title：Anesthesiology

authors： McKay RD,Sundt TM,Michenfelder JD,Gronert GA,Messick JM,Sharbrough FW,Piepgras DG

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:Patient-controlled analgesia (PCA) with intravenous morphine and patient-controlled epidural analgesia (PCEA), using an opioid either alone or in combination with a local anesthetic, are two major advances in the management of pain after major surgery. However, these techniques have been evaluated poorly in ...

journal_title：Anesthesiology

authors： Mann C,Pouzeratte Y,Boccara G,Peccoux C,Vergne C,Brunat G,Domergue J,Millat B,Colson P

更新日期：2000-02-01 00:00:00

abstract：:The effects of halothane (0.75% and 1.5%) and isoflurane (2.6%) on macroscopic Ca2+ and K+ channel currents (ICa and IK, respectively) were investigated in voltage-clamped vascular muscle cells from the canine coronary artery. Single coronary arterial cells were dialyzed with K+ glutamate solution and superfused with ...

journal_title：Anesthesiology

authors： Buljubasic N,Rusch NJ,Marijic J,Kampine JP,Bosnjak ZJ

更新日期：1992-06-01 00:00:00

abstract：:Hepatic drug-metabolizing enzymes and hepatic ultrastructure were studied in rats after two hours of anesthesia with 1 MAC halothane or diethyl ether. Twelve hours after cessation of either anesthetic smooth endoplasmic reticulum was increased in centrilobular but not in periportal hepatocytes. This change persisted a...

journal_title：Anesthesiology

authors： Ross WT Jr,Cardell RR Jr

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:Early acquisition of critical competencies by novice anesthesiology residents is essential for patient safety, but traditional training methods may be insufficient. The purpose of this study was to determine the effectiveness of high-fidelity simulation training of novice residents in the initial management ...

journal_title：Anesthesiology

authors： Park CS,Rochlen LR,Yaghmour E,Higgins N,Bauchat JR,Wojciechowski KG,Sullivan JT,McCarthy RJ

更新日期：2010-01-01 00:00:00

abstract：:This study was designed to test the hypothesis that the volatile anesthetics directly affect cardiac contractile proteins. For this purpose, the effects of various anesthetic doses of halothane, enflurane, and isoflurane on myocardial calcium sensitivity and maximal calcium-activated force were examined in rat cardiac...

journal_title：Anesthesiology

authors： Murat I,Ventura-Clapier R,Vassort G

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:A recent model of acute incisional pain has been characterized that strongly parallels the postoperative period in patients experiencing evoked pain. In that setting, abundant literature has revealed antihypersensitive effects produced by intrathecally administered alpha2-adrenergic receptor agonists, such a...

journal_title：Anesthesiology

authors： Duflo F,Boselli E,Ryvlin P,Chassard D

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:The authors compare three techniques for insertion of the ProSeal laryngeal mask airway. METHODS:Two hundred forty healthy patients aged 18-80 yr were randomly allocated for ProSeal laryngeal mask airway insertion using the digital, introducer tool (IT), or gum elastic bougie (GEB)-guided techniques. The di...

journal_title：Anesthesiology

authors： Brimacombe J,Keller C,Judd DV

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Systemically administered local anesthetics and other sodium channel blockers produce analgesia in patients with hypersensitivity disorders. To assess whether these agents have a role in the treatment of visceral pain, the present study examined the effects of intravenous lidocaine on neuronal and reflex res...

journal_title：Anesthesiology

authors： Ness TJ

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The authors determined the segmental effects of intracarotid verapamil in human subjects by using a novel method of measuring proximal and distal cerebrovascular resistance. Their hypothesis was that intracarotid verapamil, a calcium channel-blocking drug that augments cerebral blood flow and reverses arteri...

journal_title：Anesthesiology

authors： Joshi S,Meyers PM,Pile-Spellman J,Wang M,Sahlein DH

更新日期：2004-04-01 00:00:00