Potentiation of epidural opioids with epidural droperidol. A one year retrospective study.

Abstract:

:During a period of one year, 119 patients with chronic pain received injections of opioids via a catheter inserted in the lumbar epidural space. Twenty-three patients (19%) showed evidence of tolerance and were given droperidol 1.25-5.0 mg epidurally. In 20 patients in this study, there was a significant reduction in the number of epidural opioid injections. Six patients complained of excessive sedation, which disappeared when the dose of droperidol was reduced, although this did not affect the analgesia. One patient given an accidental overdose of droperidol developed reversible Parkinsonism. It is concluded that epidural administration of the dopamine antagonist droperidol may be beneficial as supplementary medication to epidural opioids when tolerance develops.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Bach V,Carl P,Ravlo O,Crawford ME,Werner M

doi

10.1111/j.1365-2044.1986.tb12959.x

subject

Has Abstract

pub_date

1986-11-01 00:00:00

pages

1116-9

issue

11

eissn

0003-2409

issn

1365-2044

journal_volume

41

pub_type

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