The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting.

Abstract:

:It is not known whether dexamethasone increases the effectiveness of anti-emetics when given to treat postoperative nausea and vomiting (PONV). In a randomised study, 242 patients who were experiencing PONV received dolasetron and placebo, haloperidol and placebo, dolasetron and dexamethasone, or haloperidol and dexamethasone. The results from 228 patients were suitable for analysis. PONV recurred significantly less frequently in patients treated with additional dexamethasone (33%) than in patients treated without additional dexamethasone (51%). The combination of dexamethasone with dolasetron or dexamethasone with haloperidol is superior to dolasetron or haloperidol alone for the treatment of PONV.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Rüsch D,Arndt C,Martin H,Kranke P

doi

10.1111/j.1365-2044.2007.05136.x

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

810-7

issue

8

eissn

0003-2409

issn

1365-2044

pii

ANA5136

journal_volume

62

pub_type

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