Abstract:
:A cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed myasthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED50 and ED90 values for suxamethonium were 0.08 mg/kg and 0.20 mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90-95% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Abel M,Eisenkraft JB,Patel Ndoi
10.1111/j.1365-2044.1991.tb09310.xsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
30-2issue
1eissn
0003-2409issn
1365-2044journal_volume
46pub_type
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