Abstract:
:Hallervorden-Spatz disease is a rare autosomal recessive disorder in which dopaminergic deficiency in the substantia nigra and its nigrostriatal projection has been identified. It is characterised by a slow but progressive course culminating in death. This case report describes a 13-year-old male, with a clinical diagnosis of Hallervorden-Spatz disease, who developed recurrent episodes of an acute illness, the features of which closely resembled those of the neuroleptic malignant syndrome. However, in this patient there had been no exposure to neuroleptic medication. The clinical events in this case suggest that dopaminergic hypoactivity, which is characteristic of Hallervorden-Spatz disease, can trigger episodes of neuroleptic malignant syndrome.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Hayashi K,Chihara E,Sawa T,Tanaka Ydoi
10.1111/j.1365-2044.1993.tb07070.xsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
499-502issue
6eissn
0003-2409issn
1365-2044journal_volume
48pub_type
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