当前位置： SCI文献检索 > NEUROPSYCHOLOGIA期刊下所有文献 > Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris Water Maze: A case study.

Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris Water Maze: A case study.

Abstract：

:Damage to the medial temporal lobes produces profound amnesia, greatly impairing the ability of patients to learn about new associations and events. While studies in rodents suggest a strong link between damage to the hippocampus and the ability to navigate using distal landmarks in a spatial environment, the connection between navigation and memory in humans remains less clear. Past studies on human navigation have provided mixed findings about whether patients with damage to the medial temporal lobes can successfully acquire and navigate new spatial environments, possibly due, in part, to issues related to patient demographics and characterization of medial temporal lobe damage. Here, we report findings from a young, high functioning patient who suffered severe medial temporal lobe damage. Although the patient is densely amnestic, her ability to acquire and utilize new, but coarse, spatial "maps" appears largely intact. Specifically, a novel computational analysis focused on the precision of her spatial search revealed a significant deficit in spatial precision rather than spatial search strategy. These findings argue that an intact hippocampus in humans is not necessary for representing multiple external landmarks during spatial navigation of new environments. We suggest instead that the human hippocampus may store and represent complex high-resolution bindings of features in the environment as part of a larger role in perception, memory, and navigation.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Kolarik BS,Shahlaie K,Hassan A,Borders AA,Kaufman KC,Gurkoff G,Yonelinas AP,Ekstrom AD

doi

10.1016/j.neuropsychologia.2015.11.013

subject

Has Abstract

pub_date

2016-01-08 00:00:00

pages

90-101

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(15)30228-1

journal_volume

80

pub_type

杂志文章

相关文献

NEUROPSYCHOLOGIA文献大全
  • Processing conflicting information: facilitation, interference, and functional connectivity.

    abstract：:When a conflict task involves congruent, neutral, and incongruent conditions, it is possible to examine facilitation (neutral vs. congruent) and interference (incongruent vs. neutral) components. Very few studies investigated the brain areas that are specifically involved in facilitation or interference. We used funct...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2008.05.025

    authors： Cohen Kadosh R,Cohen Kadosh K,Henik A,Linden DE

    更新日期：2008-10-01 00:00:00

  • The influence of time awake and circadian rhythm upon performance on a frontal lobe task.

    abstract：:Previous research has suggested a time-of-day effect for response inhibition on a task known to be dependent on frontal lobe function. We used a forced desynchronisation protocol to separate effects of circadian and sleep homeostat processes on a modified version of this task. Fourteen healthy young adults followed an...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2006.12.012

    authors： Harrison Y,Jones K,Waterhouse J

    更新日期：2007-04-09 00:00:00

  • Body inversion effect without body sense: insights from deafferentation.

    abstract：:Like faces, human bodies are recognized via the configuration of their parts; their recognition is impaired by inversion. Processing of configural relations has been shown to depend on perceptual expertise with certain classes of objects. Because people see their own body and others' bodies frequently, humans are expe...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2006.06.018

    authors： Bosbach S,Knoblich G,Reed CL,Cole J,Prinz W

    更新日期：2006-01-01 00:00:00

  • Egocentric reference and asymmetric perception of space.

    abstract：:Normal dextrals performed tactilo-kinesthetic bisection tasks in a median position, at three directions of gaze: 30 degrees to the left, 30 degrees to the right, 0 degree. Instead of pseudoneglect phenomenon, a deviation of the subjective middle to the side opposite to the direction of gaze and hand use was found, whi...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/0028-3932(93)90091-d

    authors： Chokron S,Imbert M

    更新日期：1993-03-01 00:00:00

  • Facial expression recognition in people with medicated and unmedicated Parkinson's disease.

    abstract：:Recognition of facial expressions of emotion was investigated in people with medicated and unmedicated Parkinson's disease (PD) and matched controls (unmedicated PD, n=16; medicated PD, n=20; controls, n=40). Participants in the medicated group showed some visual impairment (impaired contrast sensitivity) and performe...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/s0028-3932(02)00295-6

    authors： Sprengelmeyer R,Young AW,Mahn K,Schroeder U,Woitalla D,Büttner T,Kuhn W,Przuntek H

    更新日期：2003-01-01 00:00:00

  • Mental planning and anticipatory processes with acute and chronic frontal lobe lesions: a comparison of maze performance in routine and non-routine situations.

    abstract：:A series of computerized mazes were masked during presentation allowing only partial view of their structure. Patients suffering from acute or chronic unilateral frontal (medial, lateral) or retrorolandic (temporal, parietal) lesions and non-brain-damaged controls were required to pass through the mazes repeatedly, un...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/0028-3932(91)90042-7

    authors： Karnath HO,Wallesch CW,Zimmermann P

    更新日期：1991-01-01 00:00:00

  • Atypical recruitment of medial prefrontal cortex in autism spectrum disorders: an fMRI study of two executive function tasks.

    abstract：:Recent studies have suggested an uneven profile of executive dysfunction in autism spectrum disorders (ASD). For example, some authors have reported deficits on newly developed tests of executive function sensitive to rostral prefrontal function, despite spared, or even superior, performance on other tests. We investi...

    journal_title：Neuropsychologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neuropsychologia.2008.03.025

    authors： Gilbert SJ,Bird G,Brindley R,Frith CD,Burgess PW

    更新日期：2008-01-01 00:00:00

  • Lateralized use of the mouth in production of vocalizations by marmosets.

    abstract：:We have found that the common marmoset, Callithrix jacchus, displays a larger left hemimouth during production of fear expressions, with or without vocalization, and a larger right hemimouth when producing a social contact call. Thus, marmosets have right hemisphere specialization for the production of negative emotio...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/s0028-3932(98)00037-2

    authors： Hook-Costigan MA,Rogers LJ

    更新日期：1998-12-01 00:00:00

  • Selective loss of verbal imagery.

    abstract：:This single case study of the ability to generate verbal and non-verbal imagery in a woman who sustained a gunshot wound to the brain reports a significant difficulty in generating images of word shapes but not a significant problem in generating object images. Further dissociation, however, was observed in her abilit...

    journal_title：Neuropsychologia

    pub_type： 临床试验,杂志文章

    doi：10.1016/0028-3932(95)00120-4

    authors： Mehta Z,Newcombe F

    更新日期：1996-05-01 00:00:00

  • Sources of between-subjects variability in perceptual asymmetries: a meta-analytic review.

    abstract：:A number of studies have reported correlations between subjects' asymmetry scores on left and right hemisphere specialized tasks. In this paper we report the results of meta-analyses performed on these correlations. Results showed positive correlations between subjects' asymmetry scores on left and right hemisphere sp...

    journal_title：Neuropsychologia

    pub_type： 杂志文章,meta分析

    doi：10.1016/0028-3932(91)90053-b

    authors： Kim H,Levine SC

    更新日期：1991-01-01 00:00:00

  • Children's and adults' neural bases of verbal and nonverbal 'theory of mind'.

    abstract：:Theory of mind (ToM) - our ability to predict behaviors of others in terms of their underlying intentions - has been examined through verbal and nonverbal false-belief (FB) tasks. Previous brain imaging studies of ToM in adults have implicated medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ) for adu...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2006.11.017

    authors： Kobayashi C,Glover GH,Temple E

    更新日期：2007-04-08 00:00:00

  • Functional reorganization of the auditory pathways (or lack thereof) in callosal agenesis is predicted by monaural sound localization performance.

    abstract：:Neuroimaging studies show that permanent peripheral lesions such as unilateral deafness cause functional reorganization in the auditory pathways. However, functional reorganization of the auditory pathways as a result of higher-level damage or abnormalities remains poorly investigated. A relatively recent behavioural ...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2009.10.023

    authors： Paiement P,Champoux F,Bacon BA,Lassonde M,Mensour B,Leroux JM,Lepore F

    更新日期：2010-01-01 00:00:00

  • Influence of different types of grasping on the transport component of prehension movements.

    abstract：:The main aim of the present study was to clarify whether different types of grasping may affect the transport component of prehension movements. To this purpose two experiments were carried out. In the first experiment the kinematics of arm movements (transport and manipulation components) were studied in eight normal...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/0028-3932(91)90025-4

    authors： Gentilucci M,Castiello U,Corradini ML,Scarpa M,Umiltà C,Rizzolatti G

    更新日期：1991-01-01 00:00:00

  • Perceptual flexibility after frontal or temporal lobectomy.

    abstract：:Using stimuli with ambiguous figure-ground relationships, Ricci and Blundo (1990, Neuropsychologia 28, 1163-1173) demonstrated that patients with frontal-lobe lesions are impaired at shifting perspective. No significant difference between right frontal and left frontal groups was found. To investigate this phenomenon ...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/0028-3932(94)90159-7

    authors： Meenan JP,Miller LA

    更新日期：1994-09-01 00:00:00

  • Bilingualism alters brain functional connectivity between "control" regions and "language" regions: Evidence from bimodal bilinguals.

    abstract：:Previous neuroimaging studies have revealed that bilingualism induces both structural and functional neuroplasticity in the dorsal anterior cingulate cortex (dACC) and the left caudate nucleus (LCN), both of which are associated with cognitive control. Since these "control" regions should work together with other lang...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2015.04.007

    authors： Li L,Abutalebi J,Zou L,Yan X,Liu L,Feng X,Wang R,Guo T,Ding G

    更新日期：2015-05-01 00:00:00

  • Genetics and mathematics: FMR1 premutation female carriers.

    abstract：:Neuropsychological investigations of FMR1 premutation carriers without FXTAS present one domain resulting in contradictory findings, namely that of mathematical skills. One reason for this might be that standard clinical batteries used so far may be inadequate to uncover precise deficits within specific mathematical s...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2012.10.021

    authors： Semenza C,Bonollo S,Polli R,Busana C,Pignatti R,Iuculano T,Maria Laverda A,Priftis K,Murgia A

    更新日期：2012-12-01 00:00:00

  • Beyond Alzheimer's disease: Can bilingualism be a more generalized protective factor in neurodegeneration?

    abstract：:Bilingualism has been argued to have an impact on cognition and brain structure. Effects have been reported across the lifespan: from healthy children to ageing adults, including clinical (ageing) populations. It has been argued that active bilingualism may significantly contribute to the delaying of the expression of...

    journal_title：Neuropsychologia

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropsychologia.2020.107593

    authors： Voits T,Pliatsikas C,Robson H,Rothman J

    更新日期：2020-10-01 00:00:00

  • Hemispheric specialization for speech in retarded children.

    abstract：:Hemispheric asymmetries in retarded and normal children were examined in dichotic tests which followed extensive auditory-discrimination training and which required non-verbal responses to digits or words. Mean right-ear advantages were smaller for the retarded group than for the normal group. However, most retarded c...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/0028-3932(83)90103-3

    authors： Pipe ME,Beale IL

    更新日期：1983-01-01 00:00:00

  • Autonomy of lower-level perception from global processing in autism: evidence from brain activation and functional connectivity.

    abstract：:Previous behavioral studies have shown that individuals with autism are less hindered by interference from global processing during the performance of lower-level perceptual tasks, such as finding embedded figures. The primary goal of this study was to examine the brain manifestation of such atypicality in high-functi...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2011.04.005

    authors： Liu Y,Cherkassky VL,Minshew NJ,Just MA

    更新日期：2011-06-01 00:00:00

  • Retrograde amnesia in rats with lesions to the hippocampus on a test of spatial memory.

    abstract：:The present study examined remote spatial memory in a test that spans several months to determine whether remote memories are spared relative to more recent ones, as predicted by models of memory consolidation. At 3, 6 or 12 months of age, groups of rats received forced-choice training as to the location of food rewar...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2005.01.013

    authors： Winocur G,Moscovitch M,Caruana DA,Binns MA

    更新日期：2005-01-01 00:00:00

  • Brain structural correlates of executive and social cognition profiles in behavioral variant frontotemporal dementia and elderly bipolar disorder.

    abstract：:An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsycholo...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2017.02.012

    authors： Baez S,Pinasco C,Roca M,Ferrari J,Couto B,García-Cordero I,Ibañez A,Cruz F,Reyes P,Matallana D,Manes F,Cetcovich M,Torralva T

    更新日期：2019-03-18 00:00:00

  • Vertical biases in scene memory.

    abstract：:In a recent theoretical paper (Behavioral and Brain Sciences, 1990, 13, 519-542), Previc argued that vertical asymmetries in perception may largely result from the biases of the lower and upper visual fields toward proximal and distal space, respectively. The present study examined whether this same relationship may e...

    journal_title：Neuropsychologia

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0028-3932(97)00091-2

    authors： Previc FH,Intraub H

    更新日期：1997-12-01 00:00:00

  • Auditory cortex and anterior cingulate cortex sources of the early evoked gamma-band response: relationship to task difficulty and mental effort.

    abstract：:High frequency oscillations in the 40 Hz (gamma-band)-range are involved in the synchronization of brain regions, e.g., in cognitive functions. It has been suggested that the auditory evoked gamma-band response (GBR) is affected by attention and apart from auditory cortex activity a frontal or anterior cingulate corte...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2007.02.020

    authors： Mulert C,Leicht G,Pogarell O,Mergl R,Karch S,Juckel G,Möller HJ,Hegerl U

    更新日期：2007-06-11 00:00:00

  • Action verbs and the primary motor cortex: a comparative TMS study of silent reading, frequency judgments, and motor imagery.

    abstract：:Single pulse transcranial magnetic stimulation (TMS) was applied to the hand area of the left primary motor cortex or, as a control, to the vertex (STIMULATION: TMS(M1) vs. TMS(vertex)) while right-handed volunteers silently read verbs related to hand actions. We examined three different tasks and time points for stim...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2008.01.015

    authors： Tomasino B,Fink GR,Sparing R,Dafotakis M,Weiss PH

    更新日期：2008-01-01 00:00:00

  • Planning: fixed-foreperiod event-related potentials during the Tower of London task.

    abstract：:Slow wave ERPs were recorded from 28 young adults as they generated plans for various difficulty levels of a fixed-foreperiod version of the Tower of London task. The resulting waveform included three segments: (1) a left-lateralized negative early-interval wave, which was frontally maximal but not sensitive to diffic...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2011.02.025

    authors： Byrd DL,Case KH,Berg WK

    更新日期：2011-04-01 00:00:00

  • Material-dependent and material-independent selection processes in the frontal and parietal lobes: an event-related fMRI investigation of response competition.

    abstract：:The present study used the flanker task [Percept. Psychophys. 16 (1974) 143] to identify neural structures that support response selection processes, and to determine which of these structures respond differently depending on the type of stimulus material associated with the response. Participants performed two versio...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/s0028-3932(03)00040-x

    authors： Hazeltine E,Bunge SA,Scanlon MD,Gabrieli JD

    更新日期：2003-01-01 00:00:00

  • When seeing depends on knowing: adults with Autism Spectrum Conditions show diminished top-down processes in the visual perception of degraded faces but not degraded objects.

    abstract：:Behavioural, neuroimaging and neurophysiological approaches emphasise the active and constructive nature of visual perception, determined not solely by the environmental input, but modulated top-down by prior knowledge. For example, degraded images, which at first appear as meaningless 'blobs', can easily be recognize...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2009.12.023

    authors： Loth E,Gómez JC,Happé F

    更新日期：2010-04-01 00:00:00

  • Working memory and reward association learning impairments in obesity.

    abstract：:Obesity has been associated with impaired executive functions including working memory. Less explored is the influence of obesity on learning and memory. In the current study we assessed stimulus reward association learning, explicit learning and memory and working memory in healthy weight, overweight and obese indivi...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2014.10.004

    authors： Coppin G,Nolan-Poupart S,Jones-Gotman M,Small DM

    更新日期：2014-12-01 00:00:00

  • Cognitive estimation in patients with probable Alzheimer's disease and alcoholic Korsakoff patients.

    abstract：:Cognitive estimation is an important function in daily living. In early studies it was proposed that estimation deficits are associated with frontal lobe damage and executive dysfunctions. In this study, we assessed Alzheimer patients and patients with alcoholic Korsakoff's syndrome with a newly developed cognitive es...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/s0028-3932(02)00183-5

    authors： Brand M,Kalbe E,Fujiwara E,Huber M,Markowitsch HJ

    更新日期：2003-01-01 00:00:00

  • Adaptive phonemic coding in the listening and speaking brain.

    abstract：:In order to determine the neural substrates of phonemic coding during both listening and speaking, we used a repetition suppression (RS) paradigm in which vowels were repeatedly perceived or produced while measuring BOLD activity with sparse sampling functional magnetic resonance imaging (fMRI). RS refers to the pheno...

    journal_title：Neuropsychologia

    pub_type： 杂志文章

    doi：10.1016/j.neuropsychologia.2019.107267

    authors： Grabski K,Sato M

    更新日期：2020-01-01 00:00:00