Abstract：
:A mechanistic model of the Fitzhugh-Nagumo type is proposed for the pulse-like jasmonate response in plants. The model is composed of a bistable signaling pathway coupled to a negative feedback loop. The bistable signaling pathway describes a recently discovered positive feedback loop involving jasmonate and the MYC2 transcription factor regulating promoter activity during plant defense. The negative feedback loop is assumed to reflect a second jasmonate-dependent signaling pathway that is also used for ethylene signaling. The impact of the negative feedback loop is to destroy the high-level jasmonate fixed-point of the bistable jasmonate/MYC2 module. As a result, the high-level state becomes a ghost attractor and the jasmonate defense response becomes pulse-like.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Chiangga S,Pornkaveerat W,Frank TDdoi
10.1016/j.mbs.2016.01.001subject
Has Abstractpub_date
2016-03-01 00:00:00pages
80-90eissn
0025-5564issn
1879-3134pii
S0025-5564(16)00002-Xjournal_volume
273pub_type
杂志文章abstract：:Parallel numerical simulations of excitation and recovery in three-dimensional myocardial domains are presented. The simulations are based on the anisotropic Bidomain and Monodomain models, including intramural fiber rotation and orthotropic or axisymmetric anisotropy of the intra- and extra-cellular conductivity tens...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2005.04.003
更新日期：2005-09-01 00:00:00
abstract：:A simple model of Freeman and Johnson on cutaneous mechanoreceptors is modified by introducing mechanisms for hyperexcitation and refractoriness. These lead to significant improvements in the match between the neural and model data. ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(94)00083-c
更新日期：1995-11-01 00:00:00
abstract：:A three-dimensional diffusion model with either hexagonal or cylindrical symmetry has been constructed to simulate desorption profiles of hydrophilic chemicals from the topmost layer of human skin (the stratum corneum) as measured in ex vivo studies. The tissue is pierced by skin appendages - sweat glands and hair fol...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2018.03.010
更新日期：2018-06-01 00:00:00
abstract：:Two-dimensional pioneer-climax models of competing species differential equations are introduced and examined. The per capita growth rates are functions of weighted densities of the individual species. Constant rate forcing is added representing stocking or harvesting. The ensuring stability properties of interior equ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(96)00065-x
更新日期：1996-10-01 00:00:00
abstract：:Cooperating behaviors abound across all domains of life, but are vulnerable to invasion by cheaters. An important evolutionary question is to determine mechanisms that stabilize and maintain cooperation levels and prevent population collapse. Policing is one strategy populations may employ to achieve this goal, and it...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2019.108257
更新日期：2019-10-01 00:00:00
abstract：:The influence of intrinsic channel noise on the spiking activity of excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic dynamics of individual ion channels does affect the electric properties of the cell-membrane patches. ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.08.024
更新日期：2007-06-01 00:00:00
abstract：:The epidemiology of infectious diseases makes use of a number of terms, such as exposure, infected, carrier, attack rate, and immunity. Researchers who intend to model the spread of epidemics should be aware of the problems with some of these terms. The role played by inapparent, or subclinical, infections is receivin...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(91)90001-y
更新日期：1991-12-01 00:00:00
abstract：:Through use of the local state isomorphism theorem instead of the algebraic equivalence theorem of linear systems theory, the similarity transformation approach is extended to nonlinear models, resulting in finitely verifiable sufficient and necessary conditions for global and local identifiability. The approach requi...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(89)90024-2
更新日期：1989-04-01 00:00:00
abstract：:Emergency vaccination during an epidemic of classical swine fever virus (CSFV) has become a serious option because of the ethical problems of strategies with massive culling and the availability of a marker vaccine that reduces virus transmission. Here we present a model of between-herd CSFV transmission, which quanti...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2003.08.005
更新日期：2003-12-01 00:00:00
abstract：:WHO tuberculosis researchers recently published a mathematical model to predict TB incidence decline with fulfillment of Sustainable Development Goal (SDG) subtargets [1]. This model omitted the subtargets of land rights and basic services and of reduction in deaths from climatic disaster, likely highly influential fa...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2019.05.002
更新日期：2019-07-01 00:00:00
abstract：:This study is a theoretical excursion into gravity models and their usability in evaluating importance of spatial structure and population development for the spread of colonizing organisms. A so called "gravity score" for sites is deduced, and such a score could be used for predicting risk of colonization once one si...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2009.08.008
更新日期：2009-11-01 00:00:00
abstract：:When ionizing radiation strikes a cell it induces DNA double strand breaks (DSBs). Subsequently, some of the DSBs misrejoin and thus cause alterations in the size distribution of the DNA fragments. We derive a system of non-linear integro-differential equations describing the misrejoining interactions of five classes ...
journal_title：Mathematical biosciences
pub_type： 杂志文章,评审
doi：10.1016/s0025-5564(98)00006-6
更新日期：1998-05-01 00:00:00
abstract：:It is well known that in the most general epidemic models with multiple pathogen variants a competitive exclusion principle is valid, such that the variant with the highest reproduction number eliminates the rest. Mechanisms such as super-infection, coinfection, and cross-immunity can lead to pathogen polymorphism whe...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.09.010
更新日期：2007-05-01 00:00:00
abstract：:Many situations in population biology involve a rate--typically a contact or recruitment rate--which increases linearly for small populations but reaches a maximum value (saturates) for large populations. Models for populations of variable size need to incorporate both characteristics to predict behavior accurately. T...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2004.11.001
更新日期：2004-12-01 00:00:00
abstract：:Methods of phylogenetic inference use more and more complex models to generate trees from data. However, even simple models and their implications are not fully understood. Here, we investigate the two-state Markov model on a tripod tree, inferring conditions under which a given set of observations gives rise to such ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2012.03.001
更新日期：2012-05-01 00:00:00
abstract：:Reactivity (a.k.a initial growth) is necessary for diffusion driven instability (Turing instability). Using a notion of common Lyapunov function we show that this necessary condition is a special case of a more powerful (i.e. tighter) necessary condition. Specifically, we show that if the linearised reaction matrix an...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2012.04.006
更新日期：2012-09-01 00:00:00
abstract：:When comparing the performance of a stochastic model of an epidemic at two points in a parameter space, a threshold is said to have been crossed when at one point an epidemic develops with positive probability; while at the other there is a tendency for an epidemic to become extinct. The approach used to find threshol...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(01)00093-1
更新日期：2002-05-01 00:00:00
abstract：:A Gompertz-type diffusion process characterized by the presence of exogenous factors in the drift term is considered. Such a process is able to describe the dynamics of populations in which both the intrinsic rates are modified by means of time-dependent terms. In order to quantify the effect of such terms the evaluat...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2013.01.001
更新日期：2013-09-01 00:00:00
abstract：:Using the coalescent process, DNA sequences of a sample of individuals can be used to study the phylogenetic history of the individuals. Under the infinitely-many-sites mutation model, the DNA sequence data can be summarized by the number of segregating sites (which is numerically equivalent to the number of mutations...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(98)10029-9
更新日期：1998-10-01 00:00:00
abstract：:Two optimization problems are considered: Harvesting from a structured population with maximal gain subject to the condition of non-extinction, and vaccinating a population with prescribed reduction of the reproduction number of the disease at minimal costs. It is shown that these problems have a similar structure and...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2005.09.001
更新日期：2007-04-01 00:00:00
abstract：:A mathematical model is presented for the growth of a multicellular spheroid that comprises a central core of necrotic cells surrounded by an outer annulus of proliferating cells. The model distinguishes two mechanisms for cell loss: apoptosis and necrosis. Cell loss due to apoptosis is defined to be programmed cell d...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(96)00023-5
更新日期：1996-07-15 00:00:00
abstract：:Free access to a common pool of resource in a country may lead to over-exploitation and sacrifice future opportunities of harvesting. As such, the protection of a common fishery resource is worth investigating. In this paper we develop a two-period model and a multi-period model to analyze the optimal inter-temporal u...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.06.007
更新日期：2007-05-01 00:00:00
abstract：:Most endocrine cells secrete hormones as a result of Ca2+-regulated exocytosis, i.e., fusion of the membranes of hormone-containing secretory granules with the cell membrane, which allows the hormone molecules to escape to the extracellular space. As in neurons, electrical activity and cell depolarization open voltage...
journal_title：Mathematical biosciences
pub_type： 杂志文章,评审
doi：10.1016/j.mbs.2016.11.010
更新日期：2017-01-01 00:00:00
abstract：:Mathematical models of biological systems often have components that vary on different timescales. This multi-timescale character can lead to problems when doing computer simulations, which can require a great deal of computer time so that the components that change on the fastest time scale can be resolved. Mathemati...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2016.07.003
更新日期：2017-05-01 00:00:00
abstract：:The goal of this study is to uncover some unobservable aspects of the individual-patient natural history of metastatic renal cell carcinoma (RCC) through mathematical modeling. We analyzed four clear cell RCC patients who at the time of primary tumor resection already had pulmonary metastases. Our description of the n...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2019.01.008
更新日期：2019-03-01 00:00:00
abstract：:The ability of an organism to degrade harmful substances to less toxic compounds is referred to as metabolic resistance. The biochemical processes result in a shift of dose-response curves associated with the toxic substances. Hence, the development of metabolic resistance may cause great problems of managing pests an...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2012.11.010
更新日期：2013-03-01 00:00:00
abstract：:A mathematical analysis of the stability in human respiration, based on the tau-decomposition method, is conducted on a simple, but realistic CO2 model of the respiratory system. This model incorporates a two-compartment representation (lungs and tissues) for the plant and a very general class of controller. By derivi...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(98)10028-7
更新日期：1998-09-01 00:00:00
abstract：:The electronic structure of DNA is theoretically investigated by use of the coherent potential approximation. Even when the sequence of the four kinds of bases is nonperiodic, guanine block forms the persistent highest valence band edge, and adenine block forms the persistent lowest conduction band edge state. Accordi...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(94)00118-5
更新日期：1995-12-01 00:00:00
abstract：:Multi-patch models - also known as metapopulation models - provide a simple framework within which the role of spatial processes in disease transmission can be examined. An n-patch model which distinguishes between k different classes of individuals is considered. The linear stability of spatially homogeneous solution...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2003.09.003
更新日期：2004-03-01 00:00:00
abstract：:We apply to Michaelis-Menten kinetics an alternative approach to the study of Singularly Perturbed Differential Equations, that is based on the Renormalization Group (SPDERG). To this aim, we first rebuild the perturbation expansion for Michaelis-Menten kinetics, beyond the standard Quasi-Steady-State Approximation (s...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2017.11.012
更新日期：2018-05-01 00:00:00
