Abstract:
BACKGROUND:Little is known about how the expression of Ephrin type-A receptor 2 (EphA2) influences cell-cell adhesion, migration, angiogenesis, and the formation of vasculogenic mimicry (VM) channels in uveal melanomas or how this may be related to the rate of metastasis. MATERIAL AND METHODS:Paraffin embedded sections of 50 histopathologically well characterised primary uveal melanomas (mean largest tumour diameter: 16.3 mm) were evaluated with respect to the expression of EphA2. Systemic metastasis was detected in 29 patients. The remaining 21 patients were followed for a mean of 10 years. Tumour angiogensis was analysed by endoglin expression (CD105), the activity of the mature vascular system (von Willebrand factor) and the presence of VM (CD31/PAS staining). RESULTS:All uveal melanomas expressed EphA2, with a mean of 95.93 % positive cells ± SD: 6.3 %. There was no significant association between EphA2 and the rate of metastases (p = 0.196), endoglin expression (p = 0.652), VM (p = 0.267) or with any other clinical or histopathological factors (p < 0.05). However, there was significant up-regulation of EphA2 in the nucleus of the metastatic uveal melanoma subgroup, while cytoplasmatic localisation in the subgroup was associated with better prognosis (p = 0.006). There were low levels of EphA2 expression in the specific retinal layers, the ciliary and corneal epithelium, and the choroidal and corneal endothelium. CONCLUSION:Nuclear expression of EphA2 in this series of large tumours was significantly associated with an increased rate of metastasis. On the other hand, cytoplasmic localisation was associated with a better prognosis. As there was no correlation between EphA2 expression and angiogenesis, the mature vasculature or VM, EphA2 appears to become less important in the advanced stages of the disease.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Vukoja V,Brandenbusch T,Tura A,Nassar K,Rohrbach DJ,Lüke M,Grisanti S,Lüke Jdoi
10.1055/s-0041-110956subject
Has Abstractpub_date
2016-03-01 00:00:00pages
290-7issue
3eissn
0023-2165issn
1439-3999journal_volume
232pub_type
杂志文章abstract::Out of 1300 eyes enucleated between 1966-1974, 300 subsequently revealed histologically-proved malignant melanomas of the uvea. In 264 cases the clinical diagnosis was correctly made. In 36 cases the i.o. malignant melanomas were clinically unsuspected. The incorrect clinical diagnoses included: secondary glaucoma (30...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::1. The biosynthesis of melatonin was investigated in retinaextracts of bovine eyes in dependence of light adaptation of the animals. S-adenososyl (Methyl-14C) methionin and acetylserotonin were used as substrates. A higher melatonin-biosynthesis was found in the retina from animals which were adapted to lower illumina...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND:A high corneal astigmatism limits the attainable visual acuity and the ability of correction with spectacles or contact lenses. The astigmatism can also be an impairment for visual rehabilitation, especially after penetrating keratoplasty. A pseudohakic toric intraocular lens (T-IOL) can correct high corneal...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1246046
更新日期:2011-08-01 00:00:00
abstract::The three classical angiomatoses of the retina are described on the basis of the clinical picture. If early diagnosis is possible, the otherwise inevitable progression to exudative retinal detachment and secondary glaucoma may be avoided through extensive coagulation by laser, xenon or cryopexy. - The prognosis is bes...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050609
更新日期:1986-03-01 00:00:00
abstract:PATIENT:A 68-year-old woman presented with massive congestion of lymphatic vessels of temporal inferior conjunctiva two months after extirpation of the parotic gland for an aciniform epithelioma on the same side. Clinical findings of the right and left eye were unremarkable otherwise. The congestion resolved spontaneou...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035351
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:The ongoing and fast evolution of foldable IOL designs established the necessity to evaluate the different abilities of each lens style. The large IOL database (over 16,500 specimens) acquired in our laboratory, has permitted us to perform a clinico-pathological analysis on pseudophakic autopsy globes provid...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2001-18386
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To remind of the absolute necessity for early diagnosis in the presence of ocular signs in children giving rise to possible intraocular tumours. METHOD:Based on our own experience of intraocular tumours in children, together with findings from the literature, diagnostic criteria and methods of treatment are pr...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2001-15884
更新日期:2001-05-01 00:00:00
abstract:INTRODUCTION:Endothelial dysfunction has become a strongly discussed factor regarding glaucoma pathogenesis. In addition to peripapillary bleedings as signs of vascular damage, there is a definite correlation between glaucoma and vascular dysregulation syndrome. The aim of this study was to evaluate endothelial cell re...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0043-122677
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The diagnosis of idiopathic intracranial hypertension results from a synopsis of standardised examinations including MRI. Since the cerebrospinal fluid pressure influences the pressure of the central retinal vein, it was the purpose of the present study to evaluate whether the ophthalmodynamometric estimatio...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-963634
更新日期:2007-11-01 00:00:00
abstract::By means of fluorescein angiography extensive defects in the pigmented epithelium found in choroideremia can be shown to be present in the first ten years of life. The degeneration of the vessels of the choroid and the functional damage to the retina do not seem to take place until later. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
abstract:PURPOSE:Purpose of this study was to compare age-corrected normal values of differential luminance sensitivity (dls) of the Oculus Twinfield Perimeter with those of the Humphrey Field Analyzer 630 (HFA I). Furthermore, naso-temporal and superior-inferior asymmetries in the central visual field were analyzed. METHODS:7...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2001-19689
更新日期:2001-12-01 00:00:00
abstract::In everyday practice, intravitreal therapy in an "as needed" regimen (pro re nata, PRN) is less predictable and requires more visits (monitoring and injections taken together) with poorer functional results than with the treat and extend (T&E) regimen. Current literature supports the benefit of a switch. However, prac...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0042-118184
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:A pronounced fundus autofluorescence (lipofuscin) occurs in eyes with AMD. Parapapillary lipofuscin accumulation in the retinal pigment epithelial cells was observed in eyes with advanced glaucoma histologically. The aim of this study was to evaluate the parapapillary autofluorescence (PAF) in vivo in health...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2005-858856
更新日期:2006-04-01 00:00:00
abstract::The authors report on 120 patients who underwent iridencleisis (155 eyes). Of these, 36 had open-angle glaucoma, 26 congestive glaucoma and 54 were suffering from acute glaucoma of long standing. Two patients had exfoliation syndrome and two, secondary glaucoma. The kind of filtration bleb, postoperative complications...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054765
更新日期:1983-04-01 00:00:00
abstract::The present paper reports on experience gathered with the first 140 implantations of the Kelman II anterior chamber lens following intracapsular cataract extraction (ICCE). The technique of ICCE combined with lens implantation is described; the possible complications and the advantages of this new lens type are pointe...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054555
更新日期:1984-06-01 00:00:00
abstract::Millions of people work or spend their free time sitting in front of VDUs that induce contingent visual effects. However, only a few notice irritations in the course of everyday work: motion after-images such as the waterfall illusion or tilt after-effects are possible. A new effect may be caused by those new VDU moni...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2006-926691
更新日期:2006-08-01 00:00:00
abstract::The present paper reports on the clinical findings of a 34-year-old male patient with MELAS syndrome. MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis and strokelike episodes) belongs to a group of syndromes called mitochondrial encephalomyopathies that are characterized by changes of the mitochondrial...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046280
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:Up to now, no long-term results about squint surgery with adjustable sutures have been published although it has been practiced using the current techniques since the 1970s. The aim of the study was to analyse patient satisfaction and objective findings and to compare the results to studies about squint surge...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0033-1350912
更新日期:2013-10-01 00:00:00
abstract::The authors report a rare observation of leopard spot-like and reticular pigmentary patterns in a patient with pseudoxanthoma elasticum (PXE). Characteristic fundus changes associated with PXE have been described as angioid streaks, subretinal neovascularization membranes, peau d'orange, focal retinal pigment epitheli...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046124
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The aim of the study was to find out if pupillographic assessment of the visual field by means of pupil campimetry can identify glaucomatous visual field defects and as such be used for glaucoma screening purposes. PATIENTS AND METHODS:20 patients with open angle glaucoma and 30 healthy persons were examine...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0032-1314985
更新日期:2012-11-01 00:00:00
abstract::We report an exceptional case of fulminant endophthalmitis after uncomplicated extracapsular cataract extraction with posterior chamber lens implantation. The first unusual finding was the causative organisms, group G streptococci. These organisms are commonly found as normal flora of the skin, pharynx and gastrointes...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046045
更新日期:1991-06-01 00:00:00
abstract::Clinical tests of visual acuity are an important measure of visual function. However visual acuity is usually determined only in narrow range of luminance levels between 160 and 320 cd/m2; therefore losses of visual acuity in other ranges of light intensity can not be detected. In a distance of 80 cm from the patients...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045721
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to describe the effectiveness of aflibercept in treatment-naive patients with neovascular age related macular degeneration (nAMD) and the impact of patients' residential distance to the clinic and patients' mobility on therapy in a pro re nata regime. METHODS:A retrospective dataset ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1008-9357
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The foveo-papillary angle (FPA) on fundus photographs is the accepted standard for the measurement of ocular cyclotorsion. We assessed the inter-rater reliability of this method in healthy subjects and in patients with trochlear nerve palsies. PATIENTS AND METHODS:In this methodological study, fundus photog...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0044-101013
更新日期:2018-04-01 00:00:00
abstract::A number of cases of necrotic sclerokeratitis following eye surgery have been reported in recently published literature. The condition was presumably triggered by surgical inflammation and caused by localized occlusive vasculitis: in one case deposits of immune complexes in vessel walls were demonstrated. The authors ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050312
更新日期:1988-12-01 00:00:00
abstract::Comparative examinations were carried out under controlled conditions in 101 eyes of 66 open-angle glaucoma patients with field defects (Stages I-III according to Aulhorn) with the Octopus and Competer computerized perimeters. The results of the Octopus perimetry were selected as a reference system to evaluate the sen...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1055050
更新日期:1982-03-01 00:00:00
abstract::Nitric oxide (NO) is one of the most important messenger molecules dilating blood vessels in response to neurotransmitters and serving itself as a neurotransmitter in the brain. We explored its role in the retinal vascular regulation using a sensitive and specific NO microsensor and local perivascular microinjections ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045456
更新日期:1994-05-01 00:00:00
abstract::Instead of the operating doublemicroscope described by Harms the Zeiss slit-lamp was suspended on the microscope stand by means of two special couplings in form of two stairs, so that the biomicroscopy in the optic section can be performed also when operating, especially in surgery of the retina when using contact gla...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Due to theoretical considerations an increase in the depth of field of the diffractive IOL may be combined with a reduction in contrast sensitivity, glare sensitivity and colour perception. PATIENTS AND METHODS:A comparative analysis of both eyes was performed in ten patients with a diffractive multifocal I...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035495
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Ataxia telangiectasia is an autosomal recessive inherited multisystem disease of childhood characterized by progressive cerebellar ataxia, oculo-cutaneous telangiectasia, immunological defects with increased susceptibility to infection and malignant neoplasms. PATIENT:A 20-year-old patient with ataxia telan...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035439
更新日期:1995-04-01 00:00:00