Abstract：
:Cleanup goals for sites contaminated with persistent organic pollutants (POPs) are often established based on total contaminant concentrations. However, mounting evidence suggests that understanding contaminant bioavailability in soils is necessary for accurate assessment of contaminant exposure to humans via oral ingestion pathway. Animal-based in vivo tests have been used to assess contaminant bioavailability in soils; however, due to ethical issues and cost, it is desirable to use in vitro assays as alternatives. Various in vitro methods have been developed, which simulate human gastrointestinal (GI) tract using different digestion fluids. These methods can be used to predict POP bioavailability in soils, foods, and indoor dust after showing good correlation with in vivo animal data. Here, five common in vitro methods are evaluated and compared using PAHs and PBDEs as an example of traditional and emerging POPs. Their applications and limitations are discussed while focusing on method improvements and future challenges to predict POP bioavailability in different matrices. The discussions should shed light for future research to accurately assess human exposure to POPs via oral ingestion pathway.
journal_name
Chemospherejournal_title
Chemosphereauthors
Cui XY,Xiang P,He RW,Juhasz A,Ma LQdoi
10.1016/j.chemosphere.2016.02.041subject
Has Abstractpub_date
2016-05-01 00:00:00pages
378-389eissn
0045-6535issn
1879-1298pii
S0045-6535(16)30193-Xjournal_volume
150pub_type
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