Abstract:
:Diabetic cardiomyopathy (DCM) is associated with functional and structural pathological changes such as hypoxia and inflammation. Hypoxia-inducible factor-1α(HIF-1α) is a core transcription factor for restoring homeostasis in intracellular oxygen and has a crucial role in preventing the development of DCM. However, the effect of HIF-1α in T lymphocytes on DCM has not been reported. We established T lymphocyte-specific HIF-1α knockout homozygous mice that were injected with streptozotocin (STZ) for establishing diabetic models. Random blood glucose (RBG), body weight and the survival rate were detected. The cardiac pathological changes were evaluated by periodic acid-Schiff (PAS) staining, hematoxylin-eosin staining (HE) and Masson collagen staining. Cardiac function measurements were obtained by echocardiography. We observed the infiltration of T lymphocytes/CD3+ in the hearts by immunofluorescence stain. Also, we isolated splenic lymphocytes which would be in vitro cultured in the environment of high glucose and hypoxia. HIF-1α protein level of splenic lymphocytes was measured by Western blot. The results of this study indicate that the expression of HIF-1α in lymphocytes is activated in the complex environment of DCM consisting of hypoxia and high glucose. Also, HIF-1α in T cells plays a critical role in avoiding damage to the diabetic cardiac tissues.
journal_name
Ann Clin Lab Scijournal_title
Annals of clinical and laboratory scienceauthors
Lin Y,Tang Y,Wang Fsubject
Has Abstractpub_date
2016-01-01 00:00:00pages
32-43issue
1eissn
0091-7370issn
1550-8080pii
46/1/32journal_volume
46pub_type
杂志文章abstract:OBJECTIVE:Triple-negative breast cancer (TNBC) is one of the most common malignant, highly heterogeneous tumors in women. MicroRNAs (miRNAs), such as miR-200c, play an important role in various types of malignant cancer, including TNBC. However, the biological role of miRNA-200c in TNBC is not well understood. In this ...
journal_title:Annals of clinical and laboratory science
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abstract::Plasma cell granuloma (PCG) is a relatively rare, mass-forming lesion comprised of polyclonal plasma cells set in a background of storiform fibrosis and spindle cell proliferation. While uncommon, this lesion may occur within any site and should be included in the list of differential diagnoses for plasma cell neoplas...
journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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更新日期:1983-01-01 00:00:00
abstract:AIMS:To explore the association between platelet distribution width (PDW) and stroke in atrial fibrillation (AF) patients. METHODS:This study included 150 AF patients who were divided into stroke and non-stroke groups. Multivariate logistic regression analysis and area under the receiver operating characteristic curve...
journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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abstract::The extent to which a diagnostic observation or test contributes to a diagnosis is usually represented by a conditional, or Bayesian, probability. According to information theory, the contribution of a diagnostic observation can also be measured in bits of information. This offers a representation of the Bayes rule wh...
journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章,评审
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abstract::Acne vulgaris is a common dermatological disorder with a multifactorial pathogenesis. Oxidative status has been implicated in the pathogenesis of several skin diseases, including acne. This study was aimed to investigate the levels of oxidative stress biomarkers in acne vulgaris patients with varying severities. The s...
journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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更新日期:1978-05-01 00:00:00
abstract::A simple, fast, reproducible, and reliable fibrometer method for determination of plasma or serum plasminogen was developed. Results obtained with this method were compared to those obtained with a Coseinolytic method and a Chromogenic Substrate S-2251 method. For all three procedures, serum or plasma samples were aci...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::The transmembrane protease, serine 2-E twenty-six related gene (TMPRSS2-ERG) fusion leading to ERG overexpression, was detected in approximately 50% of prostate cancers (ranging from 35-70%). However, the published data on ERG expression in tumors from other organs and normal tissues were limited. In this study, we in...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::Gamma irradiation of blood is performed to prevent transfusion-associated graft-versus-host disease and can result in an accelerated efflux of intracellular potassium (K+). The oxygen content of the blood and the temperature at which the irradiation is carried out are two variables reported to affect this shift; they ...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::A quality control program of analyses of toxic metals in urine has been carried out in the Nordic countries since 1978. In connection with these programs, the advantages and disadvantages of lyophilized compared to natural urine specimens as control materials have been investigated in three successive similar studies....
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
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doi:
更新日期:1991-09-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章,评审
doi:
更新日期:1975-05-01 00:00:00
abstract::In vitro determination of specific IgE antibodies in serum is the most frequently used method, besides the skin test, for diagnosing allergies. Standardized and reproducible assays of specific IgE antibodies contribute to the quality of diagnosis and treatment of allergic disease. This study compared the results and p...
journal_title:Annals of clinical and laboratory science
pub_type: 临床试验,杂志文章
doi:
更新日期:2005-07-01 00:00:00
abstract::Until recently it has been generally accepted that the choroid plexuses are the major source of the cerebrospinal fluid (CSF). However, data now indicate that significant contributions to the CSF are made at extrachoroidal sites. CSF production studies and 24Na transport studies in normal and plexectomized rhesus monk...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2016-09-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
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journal_title:Annals of clinical and laboratory science
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doi:
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journal_title:Annals of clinical and laboratory science
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更新日期:2001-07-01 00:00:00
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更新日期:2019-03-01 00:00:00
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journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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更新日期:1992-09-01 00:00:00
abstract::Neuroblastoma is the most common malignancy in children less than one year of age, but is rare in adults. Adult neuroblastoma differs from pediatric cases by lacking classical features including low incidence of MYCN amplification, elevated urinary catecholamimes, and MIBG avidity. The diagnosis may not be initially c...
journal_title:Annals of clinical and laboratory science
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abstract::Pancreatic cancer is one of the most lethal diseases among solid malignancies. Most patients are diagnosed in the late stage or after metastasis. Notably, pancreatic cancer is resistant to chemotherapy and lacks efficient target therapy methods. Given that, investigating the mechanism of metastasis, finding biomarkers...
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journal_title:Annals of clinical and laboratory science
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