Abstract：
:Tamoxifen citrate, the most extensively evaluated antiestrogen, acts primarily as a cytostatic agent by binding to the estrogen receptor. In rodent mammary model systems, when tamoxifen is given continuously after exposure to a carcinogen, the majority of expected tumors do not develop. In humans, adjuvant tamoxifen therapy, particularly when given for several years, is associated with significant improvement in relapse-free, and, in some studies, absolute survival. These benefits are achieved without major clinical toxicity and have led to suggestions that the use of tamoxifen as a chemopreventive agent in breast cancer be evaluated. In considering timing, optimal study population, study design, and methods for a chemoprevention trial using tamoxifen, the need for further data on the pharmacologic, biologic, and symptomatic effects of this agent becomes clear. Studies addressing this need are in progress and combined with ancillary data developed from ongoing adjuvant studies, should provide the critical information within the next few years.
journal_name
Prev Medjournal_title
Preventive medicineauthors
Love RRdoi
10.1016/0091-7435(89)90037-6subject
Has Abstractpub_date
1989-09-01 00:00:00pages
661-71issue
5eissn
0091-7435issn
1096-0260journal_volume
18pub_type
杂志文章,评审abstract：:Glucocorticoid-induced bone loss is dose- and duration-related, develops rapidly (within months of therapy), and leads to an increased risk of fractures. Moreover, less than one in four patients prescribed oral glucocorticoids receive any treatment to prevent or treat osteoporosis. The American College of Rheumatology...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/s0091-7435(02)00019-1
更新日期：2003-02-01 00:00:00
abstract：:Despite rapid growth in resources devoted to physical activity promotion, the public health capacity to address physical inactivity is insufficient. Too few public health practitioners have the necessary skills to implement and evaluate evidence-based physical activity interventions, and schools of public health typic...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2009.06.027
更新日期：2009-10-01 00:00:00
abstract：:Using participants (N = 1733) drawn from the nationally representative longitudinal Young Finns Study (YFS) we estimate the effect of education on depressive symptoms. In 2007, when the participants were between 30 and 45 years old, they reported their depressive symptoms using a revised version of Beck's Depression I...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2018.08.026
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Despite established links among heavy alcohol consumption, other poor health behaviors, and poor health status, no Canadian study has specifically addressed the relationship between drinking and the use of preventive healthcare services. This study examines the relationship between drinking and female-specif...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/s0091-7435(03)00141-5
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Little is known about the perception of bilateral prophylactic mastectomy (BPM), and whether perceptions are influenced by a family history of breast cancer. It is also unclear what factors may play a role in selecting BPM for follow-up care. METHODS:Samples of predominantly Caucasian, well-educated women w...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.1999.0524
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:Regular use of recommended preventive health services can promote good health and prevent disease. However, individuals may forgo obtaining preventive care when they are busy with competing activities and commitments. This study examined whether time pressure related to work obligations creates barriers to ob...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2015.03.008
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:We have evaluated high-risk behavior of adolescents 12 to 17 years of age on the basis of seven binomial psychosocial variables in order to assess whether there is a tendency of these variables to cluster in the same individuals and to identify socioeconomic covariates of risky behavior. METHODS:Study parti...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.1996.0130
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:To report on the contribution walking makes to total weekly physical activity and the relationship between the volume and intensity of walking and leanness in a representative sample of the Northern Ireland population. METHOD:4563 adults participated in this cross-sectional survey of physical activity behavi...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2011.12.008
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To explore the temporal relationship between 9/11-related posttraumatic stress disorder (PTSD) and new-onset diabetes in World Trade Center (WTC) survivors up to 11 years after the attack in 2001. METHODS:Three waves of surveys (conducted from 2003 to 2012) from the WTC Health Registry cohort collected data ...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2014.05.016
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Lifetime risk estimates of disease are limited by long-term data extrapolations and are less relevant to individuals who have already lived a period of time without the disease, but are approaching the age at which the disease risk becomes common. In contrast, short-term age-conditional risk estimates, such ...
journal_title：Preventive medicine
pub_type： 杂志文章,meta分析
doi：10.1006/pmed.1998.0399
更新日期：1999-02-01 00:00:00
abstract：:Abuse of widely available, over-the-counter (OTC) drugs and supplements such as diet pills, laxatives, and diuretics by adolescents for weight control is well-documented, yet manufacturers and retailers can sell them to minors without restriction. The aim of our study was to estimate the effect of added taxation of OT...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2018.05.022
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:To investigate geographic differences in obesity related metabolic abnormalities in middle-aged and older Chinese people with different levels of adiposity. METHOD:Data from 3289 individuals aged 50-70 years who participated in a cross-sectional survey in 2005 (1641 from northern [Beijing] and 1648 from sout...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2009.01.004
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Despite the availability of condoms and theoretically based interventions to promote their use, sexually active women aged 15 to 25 years continue to put themselves at risk for sexually transmitted diseases and unintended pregnancy. METHODS:One hundred ninety-eight inner city women were interviewed about kn...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2004.04.037
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:Cervical cancer causes over 4000 deaths yearly in the United States, although highly preventable through vaccination, screening, and early treatment. We aimed to determine demographic correlates for cervical cancer in North Carolina to identify target populations for interventions and to create a framework fo...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.01.020
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:This study explores the predisposing, enabling, and need-based factors associated with parents' or guardians' decision to have their child initiate, continue, and complete the human papillomavirus (HPV) vaccine. METHODS:Parents and guardians of children between the ages of 9 and 17years who completed the 20...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2016.01.010
更新日期：2016-04-01 00:00:00
abstract：:This paper reviews research studies evaluating the use of financial incentives to promote weight control conducted between 1972 and 2010. It provides an overview of behavioral theories pertaining to incentives and describes empirical studies evaluating specific aspects of incentives. Research on financial incentives a...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ypmed.2011.12.024
更新日期：2012-11-01 00:00:00
abstract：:In Canada, opioid-related overdose mortality has steeply increased in recent years; as a substantial number of opioid-related deaths are related to fentanyl products, this phenomenon has widely been described as the 'fentanyl epidemic', also implying that these deaths are largely caused by clandestinely produced illic...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2017.11.001
更新日期：2018-02-01 00:00:00
abstract：:Only a small fraction of the health-care dollar is directed toward lifestyle changes that would reduce the social burden from cardiovascular diseases (CVD). Here we discuss the challenge, opportunity, methods, and potential for managed care to implement risk reduction strategies and preventive care. A systematic team ...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1006/pmed.1999.0563
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVE:To determine whether adherence to home exercise interventions for the prevention of falls in older adults relates to home exercise program characteristics and intervention efficacy. METHODS:In Australia (2011) a systematic literature search of four databases was conducted. Randomized controlled trials were i...
journal_title：Preventive medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ypmed.2012.07.007
更新日期：2012-10-01 00:00:00
abstract：:Black and Hispanic communities in the U.S. have endured a disproportionate burden of COVID-19-related morbidity and mortality. Racial and ethnic health disparities such as these are frequently aggravated by inequitable access to healthcare resources in disadvantaged communities. Yet, no known studies have investigated...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2020.106282
更新日期：2020-12-01 00:00:00
abstract：:Retirement is a major life-course transition that is closely related to changes in health. This study examined the dynamic impact of retirement on health and health behaviors, distinguishing an immediate change in the level of health at retirement and a change in the rate of change after retirement. We used panel data...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2017.04.007
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To review the published literature on the effectiveness of web-based interventions designed to decrease consumption of alcohol and/or prevent alcohol abuse. METHOD:Relevant articles published up to, and including, May 2006 were identified through electronic searches of Medline, PsycInfo, Embase, Cochrane Lib...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ypmed.2008.01.005
更新日期：2008-07-01 00:00:00
abstract：:One of the major limitations in studying alcohol's effect on risk for diabetes is the issue of classifying drinking patterns across the life course prior to the onset of diabetes. Furthermore, this research often overlooks important life course risk factors such as obesity and early-life health problems that may compl...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2018.01.010
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Adequate care for patients with cardiovascular risks requires an adequate practice organization. Educational outreach visits are a promising approach to modifying professional behavior. We aimed to assess whether the quality of cardiovascular preventive care in general practice can be improved through a comp...
journal_title：Preventive medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1006/pmed.2002.1095
更新日期：2002-11-01 00:00:00
abstract：:The most convincing evidence for a preventive role for any modality is obviously demonstration of incidence reduction produced by that modality. However, cancer prevention trials with cancer incidence as an endpoint have logistic problems rendering them essentially impossible to conduct for most malignancies. Hence a ...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1006/pmed.1993.1064
更新日期：1993-09-01 00:00:00
abstract：:Sunburn is associated with an increased risk for skin cancer. Denmark has one of the highest incidences of melanoma in the world, although it is a relatively northern country. The objective of this study was to determine whether sunburn is associated with demographic factors and health behaviour among young Danes. Cro...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2018.08.009
更新日期：2019-01-01 00:00:00
abstract：:Group Health Cooperative (GHC) of Puget Sound is a prepaid health plan with 285,000 enrollees and 340 physicians. In 1978 a "criterion analysis" approach was instituted to develop medical staff recommendations about preventive care. By 1979, two recommendations evolved discouraging the "routine" use of: (a) chest X ra...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(83)90247-5
更新日期：1983-05-01 00:00:00
abstract：BACKGROUND:This paper examines the prevalence of household and car smoking restrictions, factors associated with these restrictions, and children's exposure to secondhand smoke in homes with varying levels of household smoking restrictions in rural Native American and White families. METHODS:In-person interviews were ...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.2002.1091
更新日期：2002-10-01 00:00:00
abstract：:The role of dietary fat in human blood pressure control was studied among 84 middle-aged subjects (mainly couples) in two semirural communities in North Karelia, Finland. The families were randomly allocated into two groups that, after a baseline period of 2 weeks, changed their diet for a 12-week intervention period ...
journal_title：Preventive medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0091-7435(85)90078-7
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVE:To test a computer-delivered program for preventing substance use among adolescent girls. METHODS:Randomly, 916 girls aged 12.76+/-1.0 years and their mothers were assigned to an intervention arm or to a test-only control arm. Intervention-arm dyads engaged in exercises to improve the mother-daughter relatio...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2009.08.001
更新日期：2009-11-01 00:00:00
