Abstract：
:The most convincing evidence for a preventive role for any modality is obviously demonstration of incidence reduction produced by that modality. However, cancer prevention trials with cancer incidence as an endpoint have logistic problems rendering them essentially impossible to conduct for most malignancies. Hence a workable strategy often involves analysis of other, indirect lines of evidence to reach conclusions. For oral cancer, dietary epidemiologic evidence points to a protective role for foods rich in carotenoids. Other anti-oxidants, such as vitamin C, are also implicated. Similarly, laboratory evidence points to a carcinogenesis inhibitory role for both retinoids and carotenoids. Clinical studies have targeted premalignant lesions, i.e., oral leukoplakia. For over two decades the efficacy of retinoids, natural and synthetic, has been known. Nevertheless, it has been difficult to translate this into a recommendation for prevention because of the toxicity of retinoids. The synthetic retinoid most often used in these trials is 13-cis-retinoic acid. This compound is toxic even at very low doses (0.1 mg/kg/day), particularly when given over several weeks to months. Hence, although effective, it cannot be advocated for prevention or oral cavity cancer. Studies with nontoxic antioxidants, such as beta-carotene, are much more recent. Early results are promising in that beta-carotene, alone or in combination with other nutrients, can reverse oral leukoplakia without toxicity in short-term trials. Studies currently under way will demonstrate whether durable remissions can be obtained using this strategy. It should be emphasized that such long-term trials are problematic to conduct with the toxic retinoids because the risks of prolonged exposure to them outweighs the chance of cancer development in the usual leukoplakia lesion.
journal_name
Prev Medjournal_title
Preventive medicineauthors
Garewal H,Meyskens F Jr,Friedman S,Alberts D,Ramsey Ldoi
10.1006/pmed.1993.1064subject
Has Abstractpub_date
1993-09-01 00:00:00pages
701-11issue
5eissn
0091-7435issn
1096-0260pii
S0091-7435(83)71064-9journal_volume
22pub_type
杂志文章,评审abstract：BACKGROUND:It is proposed that, historically, when the conditions are right for laboratory sciences to contribute to causal knowledge, they take the place of epidemiology as leaders in a given field. METHODS:Review examples of cholera, pellagra, and Kaposi's sarcoma. RESULTS:In the cases of cholera, pellagra, and Kap...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ypmed.2011.07.018
更新日期：2011-10-01 00:00:00
abstract：:A decision theoretic model was used to investigate the relative importance of risk level, radiation hazard, mammographic accuracy, and cost in mammographic screening decision. The model uses woman-specific medical and family history facts and clinic-specific information regarding mammographic accuracy and practice to ...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(88)90060-6
更新日期：1988-03-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to examine depressive symptom trajectories during adolescence as predictors of physical activity (PA) in young adulthood. METHODS:Adolescents residing in Montreal, Canada (n=860) reported their depressive symptoms every 3-4 months during high school in 20 data collections. Thre...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2012.11.013
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:Rural women have limited exercise opportunities and significant barriers to engaging in physical activity. This study assessed the effect of a brief primary care based walking intervention in rural women. METHODS:The participants were recruited in March, 2003 by a primary care nurse at three locations in rur...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2006.10.009
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:Although patterns of utilization of complementary and alternative medicine (CAM) in the community have begun to be described, few studies have addressed the relationships between dispositional psychological factors and the use of CAM. The aim of this study was to examine the associations between CAM use and ...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2004.05.001
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:The aim of this experiment was to examine the differential impact of a narrative and a non-narrative skin cancer message on health promoting actions and information-seeking behaviors. METHODS:Participants were 230 Flemish university students aged 18 to 25 years who participated in a web based experiment in F...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2010.04.019
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:This study was undertaken to evaluate a smoking cessation intervention provided to women smokers as follow-up to cervical cancer screening. METHODS:Women who had had a Pap test in the prior month (N = 4,053) were called to complete a survey that assessed smoking status; 580 identified smokers were randomized...
journal_title：Preventive medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1006/pmed.1999.0514
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVE:The screening context may provide a "teachable moment" for promoting health behaviours. The present study examined the impact on diet, alcohol and physical activity of providing individually-tailored advice in the context of flexible sigmoidoscopy (FS) screening. METHOD:Adults (n=365) aged 58-59 years who at...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2010.10.002
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION:Interventions targeting children's dietary behavior often include strategies that target parents as implementation agents of change, though parent involvement on intervention effectiveness is unclear. The present study systematically assessed (1) reporting of reach, effectiveness, adoption, implementation ...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ypmed.2016.08.030
更新日期：2016-10-01 00:00:00
abstract：:We compared changes in academic achievement across 3years between children in elementary schools receiving the Academic Achievement and Physical Activity Across the Curriculum intervention (A+PAAC), in which classroom teachers were trained to deliver academic lessons using moderate-to-vigorous physical activity (MVPA)...
journal_title：Preventive medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ypmed.2017.02.006
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:African American women aged 50 and older are disproportionately affected by the HIV/AIDS epidemic. Despite African Americans making up 11% of all older women in the United States, in 2001, they accounted for more than 50% of AIDS cases among older women and more than 65% of HIV cases among older women. Using...
journal_title：Preventive medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ypmed.2004.03.005
更新日期：2004-10-01 00:00:00
abstract：:This report describes a systematic literature review of voucher and related monetary-based contingency management (CM) interventions for substance use disorders (SUDs) over 5.2years (November 2009 through December 2014). Reports were identified using the search engine PubMed, expert consultations, and published biblio...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ypmed.2016.08.008
更新日期：2016-11-01 00:00:00
abstract：:Using X-ray fluorescence spectrometry, 11 heavy elements at concentrations that are easily detectable have been identified in smokeless tobacco products. These concentrations were found to increase in cheek epithelium samples of the user after exposure to smokeless tobacco. This feasibility study suggests that the lev...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(88)90048-5
更新日期：1988-07-01 00:00:00
abstract：OBJECTIVE:To evaluate BMI and direct measures of body fat (BF) and lean body mass (LBM) in relation to fasting serum lipid profiles in a large Chinese population based twin sample using a monozygotic (MZ) co-twin analysis. METHODS:Adiposity measures collected 1998-2000 on 987 MZ female 20-60 year old twin pairs (n=197...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2007.07.014
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:The aims of this study were to describe the prevalence, trends, and correlates of physical activity among a national sample of pregnant women. METHOD:Using data collected from the 1999-2006 National Health and Nutrition Examination Survey, physical activity and sedentary behaviors were collected during inter...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2009.12.015
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:To determine the association between self-reported diabetes and posttraumatic stress disorder (PTSD) among adults in the community and to investigate the specificity of this link. METHOD:Data were drawn from the National Comorbidity Survey (NCS), a household probability sample of adults ages 15-54 in the Uni...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2004.07.013
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:The aim of the current study was to examine the interrelationship between certain cardiovascular disease (CVD) risk factors and overweight, as well as to provide some indication on the prevalence of underweight, overweight and obesity in primary schoolchildren in urban Turkey. METHODS:1044 randomly selected...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2004.11.029
更新日期：2005-08-01 00:00:00
abstract：:There is substantial evidence that type 2 diabetes mellitus (T2DM) can be prevented in high-risk individuals by a lifestyle program of regular exercise and weight reduction. Additionally, there is emerging evidence that new onset T2DM (<1year) can go into remission after weight loss and exercise in a majority of motiv...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2015.03.014
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:Despite the burden of colorectal cancer and improved health care outcomes with early detection and treatment, screening rates among eligible adults are low. We previously developed through a series of studies an interactive electronic tool, Colorectal Web, to promote colorectal cancer screening. METHOD:From ...
journal_title：Preventive medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ypmed.2007.07.003
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:Numerous studies have observed higher rates of smoking among adults with mental health conditions. We examined posttraumatic stress disorder (PTSD) and smoking over a 7-9year period among adults with firsthand exposure to the 9/11 attacks enrolled in the World Trade Center Health Registry. METHOD:Data were c...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2015.01.023
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:Inflammatory processes contribute to disease pathways and may be affected by behavioral lifestyle factors. The relative contributions of fatness and cardiorespiratory fitness to inflammatory factors remain unclear. The present review examines the hypothesis that the association between fitness and inflammator...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ypmed.2006.09.005
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:This study was undertaken to determine the effects of month-long whole grain oat and wheat cereal supplementation on endothelial function following a fatty meal as measured by brachial artery reactivity studies. METHODS:Fifty healthy adult subjects underwent brachial artery reactivity studies before and aft...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1006/pmed.2001.0918
更新日期：2001-11-01 00:00:00
abstract：:The benefits of physical activity are established, however, increasing population physical activity levels remains a challenge. Participating in activities that are enjoyable and multidimensional, such as dancing, are associated with better adherence. However, the extent to which the general population participates in...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2017.11.005
更新日期：2018-01-01 00:00:00
abstract：:The systematic review investigated the effectiveness of active travel (AT) interventions on physical activity and fitness in primary school children. The review assessed intervention effectiveness, design, complexity, and study quality. Searches were conducted in five databases on 30/08/2018. Studies with an AT interv...
journal_title：Preventive medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.ypmed.2019.03.030
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:This study investigated the cost-effectiveness of installing sidewalks to increase levels of transport-walking. METHODS:Secondary analysis using logistic regression established the association of sidewalks with transport-walking using two transport-walking thresholds of 150 and 60 min/week using Western Aust...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2014.07.041
更新日期：2014-10-01 00:00:00
abstract：:Despite increasing interest in worksite exercise programs, little attention has been focused on the blue-collar segment of the workforce. Because of their low participation in traditional exercise classes and programs, blue-collar workers at a university were targeted for an exercise program tailored specifically to t...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(88)90010-2
更新日期：1988-05-01 00:00:00
abstract：OBJECTIVE:The purpose of this review is to evaluate the current state-of-the-science for interventions to increase bone mass gains in children and adolescents using weight-bearing physical activity or calcium supplementation. METHODS:Studies were located using computerized and manual searches of the empirical literatu...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1006/pmed.2000.0758
更新日期：2000-12-01 00:00:00
abstract：:Some questions about adolescent smoking levels as reported in national surveys were recently raised by M. B. Mittelmark, D. M. Murray, R. N. Luepker, and T. F. Pechacek, [Prev. Med. 11, 708-712 (1982)]: such levels may be underreported, calling into question the decline in adolescent smoking. The present article sugge...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/0091-7435(84)90033-1
更新日期：1984-07-01 00:00:00
abstract：BACKGROUND:Although the initial effectiveness of psychosocial strategies programming in preventing smoking and other drug abuse among adolescents has been well established through literature reviews and meta-analyses, much less evidence exists for the long-term follow-up success of these interventions. The primary goal...
journal_title：Preventive medicine
pub_type： 杂志文章,评审
doi：10.1016/s0091-7435(03)00166-x
更新日期：2003-11-01 00:00:00
abstract：:Some cancer survivors report spending 20% of their annual income on medical care. Undue financial burden that patients face related to the cost of care is referred to as financial hardship, which may be more prevalent among rural cancer survivors. This study examined contrasts in financial hardship among 1419 rural an...
journal_title：Preventive medicine
pub_type： 杂志文章
doi：10.1016/j.ypmed.2019.105881
更新日期：2019-12-01 00:00:00
