Abstract:
:In this issue of Molecular Cell, Taneja et al. (2017) uncover a dual role for the conserved chromatin remodeler Fft3 in the maintenance of silent heterochromatin and the suppression of replication barriers at euchromatic loci through controlled histone turnover.
journal_name
Mol Celljournal_title
Molecular cellauthors
Fortuny A,Polo SEdoi
10.1016/j.molcel.2017.03.015subject
Has Abstractpub_date
2017-04-06 00:00:00pages
3-4issue
1eissn
1097-2765issn
1097-4164pii
S1097-2765(17)30205-8journal_volume
66pub_type
杂志文章相关文献
MOLECULAR CELL文献大全abstract::We used computational algorithms to find conserved sequences in the 3' untranslated region (UTR) of transcripts that exhibited rapid decay in primary human T cells and found that the consensus sequence UGUUUGUUUGU, which we have termed a GU-rich element (GRE), was enriched in short-lived transcripts. Using a tet-off r...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.11.024
更新日期:2008-02-01 00:00:00
abstract::Chaperone-mediated autophagy (CMA) is involved in cellular quality control, and in the response to stress, deterioration in CMA contributes to the aging phenotype and to various disorders. The paper by Bandyopadhyay et al. in this issue of Molecular Cell demonstrates the role of GTP binding by elongation factor 1 alph...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.08.005
更新日期:2010-08-27 00:00:00
abstract::While gapmers efficiently knock down as well as terminate transcription of nascent lncRNAs and mRNAs, Lee and Mendell (2020) and Lai et al. (2020) also demonstrate that Pol II termination is not observed with gapmers targeting the 3' terminal portions of the transcript. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2020.02.010
更新日期:2020-03-05 00:00:00
abstract::Two new studies provide in vivo ( [this issue of Molecular Cell]) and in vitro ( [this issue of Molecular Cell]) evidence that poleta functions to extend 3' strands exchanged during homologous recombination and raise the issue of how TLS polymerases are selected onto different substrates. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.molcel.2005.11.018
更新日期:2005-12-09 00:00:00
abstract::Members of the ISWI family of chromatin remodeling factors exhibit ATP-dependent nucleosome sliding, loading, and spacing activities in vitro. However, it is unclear which of these activities are utilized by ISWI complexes to remodel chromatin in vivo. We therefore sought to identify the mechanisms of chromatin remode...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00436-2
更新日期:2003-11-01 00:00:00
abstract::Salmonella force their way into nonphagocytic host intestinal cells to initiate infection. Uptake is triggered by delivery into the target cell of bacterial effector proteins that stimulate cytoskeletal rearrangements and membrane ruffling. The Salmonella invasion protein A (SipA) effector is an actin binding protein ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(04)00053-x
更新日期:2004-02-27 00:00:00
abstract::The Bloom syndrome helicase BLM and topoisomerase-IIβ-binding protein 1 (TopBP1) are key regulators of genome stability. It was recently proposed that BLM phosphorylation on Ser338 mediates its interaction with TopBP1, to protect BLM from ubiquitylation and degradation (Wang et al., 2013). Here, we show that the BLM-T...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.02.012
更新日期:2015-03-19 00:00:00
abstract::Identifying DNA fragile sites is crucial to reveal hotspots of genomic rearrangements, yet their precise mapping has been a challenge. A new study in this issue of Molecular Cell (Canela et al., 2016) introduces a highly sensitive and accurate method to detect DNA breaks in vivo that can be adapted to various experime...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.08.012
更新日期:2016-09-01 00:00:00
abstract::Klein et al. (2020) demonstrate for the first time that small-molecule cancer therapeutics are selectively partitioned and concentrated within phase-separated nuclear condensates, providing new insights to drug efficacy and creating the opportunity for enhanced control of therapeutic targeting. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2020.07.029
更新日期:2020-08-20 00:00:00
abstract::Cell death, as a foil to cell expansion, has become one of the most intensively studied research areas of modern biology. Almost every aspect of life is intimately enmeshed with the proper regulation of cell death, which either contributes to or forms the basis of most human disease pathogenesis. Now, with our ever-ex...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2007.11.016
更新日期:2007-12-14 00:00:00
abstract::BRAF is an oncogenic protein kinase that drives cell growth and proliferation through the MEK-ERK signaling pathway. BRAF inhibitors have demonstrated antitumor efficacy in melanoma therapy but have also been found to be associated with the development of cutaneous squamous cell carcinomas (cSCCs) in certain patients....
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.08.044
更新日期:2013-10-24 00:00:00
abstract::To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.05.028
更新日期:2012-06-08 00:00:00
abstract::We demonstrate that the major in vivo targets of brefeldin A (BFA) in the secretory pathway of budding yeast are the three members of the Sec7 domain family of ARF exchange factors: Gea1p and Gea2p (functionally interchangeable) and Sec7p. Specific residues within the Sec7 domain are important for BFA inhibition of AR...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)80455-4
更新日期:1999-03-01 00:00:00
abstract::mRNAs form ribonucleoprotein complexes (mRNPs) by association with proteins that are crucial for mRNA metabolism. While the mRNP proteome has been well characterized, little is known about mRNP organization. Using a single-molecule approach, we show that mRNA conformation changes depending on its cellular localization...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.10.010
更新日期:2018-11-15 00:00:00
abstract::FUS is a nuclear RNA-binding protein, and its cytoplasmic aggregation is a pathogenic signature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It remains unknown how the FUS-RNA interactions contribute to phase separation and whether its phase behavior is affected by ALS-linked mutations. He...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2019.09.022
更新日期:2020-01-02 00:00:00
abstract::HIV-1 Vpu interacts with CD4 in the endoplasmic reticulum and triggers CD4 degradation, presumably by proteasomes. Human beta TrCP identified by interaction with Vpu connects CD4 to this proteolytic machinery, and CD4-Vpu-beta TrCP ternary complexes have been detected by coimmunoprecipitation. beta TrCP binding to Vpu...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)80056-8
更新日期:1998-03-01 00:00:00
abstract::The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2 is modulated by histone modifications associated with transcriptionally active chromatin. We provide the molecular basis of histone H3 N terminus recognition by...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.03.025
更新日期:2011-05-06 00:00:00
abstract::A major unresolved question in messenger RNA translation is how ribosomal release factors terminate protein synthesis. Class 1 release factors decode stop codons and trigger hydrolysis of the bond between the nascent polypeptide and tRNA some 75 A away from the decoding site. While the gross features of the release fa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.06.032
更新日期:2007-09-07 00:00:00
abstract::In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interactions between RNA molec...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/s1097-2765(02)00429-x
更新日期:2002-01-01 00:00:00
abstract::Metabolic reprogramming is a characteristic of cancer cells. Three studies published in this month's Molecular Cell provide novel insights into the role of mitochondrial pyruvate in tumor metabolism and describe how targeting pyruvate transport and metabolism may afford therapeutic benefit. ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2014.10.018
更新日期:2014-11-06 00:00:00
abstract::BRCA1 functions at two distinct steps during homologous recombination (HR). Initially, it promotes DNA end resection, and subsequently it recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprotein filaments. Loss of 53BP1 rescues the HR defect in BRCA1-deficient cells by increasing resecti...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.12.010
更新日期:2019-03-21 00:00:00
abstract::While the function of most small signaling domains is confined to binary ligand interactions, the peroxisomal Pex13p SH3 domain has the unique capacity of binding to two different ligands, Pex5p and Pex14p. We have used this domain as a model to decipher its structurally independent ligand binding sites. By the combin...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(02)00749-9
更新日期:2002-11-01 00:00:00
abstract::Gene expression mediated by viral vectors is subject to cell-to-cell variability, which limits the accuracy of gene delivery. When coupled with single-cell measurements, however, such variability provides an efficient means to quantify signaling dynamics in mammalian cells. Here, we illustrate the utility of this appr...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.01.014
更新日期:2011-02-04 00:00:00
abstract::Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role of BRD4 in cancer has been attributed mainly to the abundant long isoform (BRD4-L). Here we show, by isoform-specific knockdown and endogenous protein d...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2020.04.034
更新日期:2020-06-18 00:00:00
abstract::Floral transition in plants is regulated by an integrated network of flowering genetic pathways. We show that an Arabidopsis PIN1-type parvulin 1, Pin1At, controls floral transition by accelerating cis/trans isomerization of the phosphorylated Ser/Thr-Pro motifs in two MADS-domain transcription factors, SUPPRESSOR OF ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.12.020
更新日期:2010-01-15 00:00:00
abstract::Tumor progression shares many characteristics with the process of epithelial-to-mesenchymal transition (EMT). Cells that have undergone an EMT are known to have an increased resistance to apoptosis. CD95/Fas is an apoptosis-inducing receptor expressed on many tissues and tumor cells. During tumor progression CD95 is f...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.05.018
更新日期:2010-06-25 00:00:00
abstract::Cotranscriptional loading of proteins onto nascent transcripts contributes to the formation of messenger ribonucleoprotein particles (mRNPs) competent for nuclear export. The transcription machinery is believed to play a pivotal role in mRNP assembly, which is at least partially linked to the function of the THO/TREX ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2004.09.019
更新日期:2004-10-22 00:00:00
abstract::We show that the IRF-2 oncoprotein represses virus-induced IFN-beta gene transcription via a novel mechanism. Virus infection induces recruitment of IRF-2 to some of the endogenous IFN-beta enhancers as part of the enhanceosome. Enhanceosomes bearing IRF-2 cannot activate transcription, due to the presence of a domain...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(05)00081-x
更新日期:2000-10-01 00:00:00
abstract::In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by HBO1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influences origin usage. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2009.12.028
更新日期:2010-01-15 00:00:00
abstract::Alternative splicing (AS) is a widespread process underlying the generation of transcriptomic and proteomic diversity and is frequently misregulated in human disease. Accordingly, an important goal of biomedical research is the development of tools capable of comprehensively, accurately, and efficiently profiling AS. ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.08.018
更新日期:2018-10-04 00:00:00