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Guided bone regeneration with particulate vs. block xenogenic bone substitutes: a pilot cone beam computed tomographic investigation.

Abstract：

AIM:To test whether an equine bone substitute block used for guided bone regeneration (GBR) of peri-implant defects differs from bovine block or particulate bone substitutes regarding the hard and soft tissue contours of the augmented ridge. MATERIAL & METHODS:Two semi-saddle bone defects were prepared in each side of the mandible of eight dogs, and one titanium implant was inserted into every defect. The defects were randomly allocated to receive one of the following treatments: bone augmentation by GBR using (1) particulate deproteinized bovine bone mineral (DBBM) + a collagen membrane (CM), (2) block DBBM + CM, (3) equine bone substitute block + CM, and (4) empty controls. After 4 months, the jaws were scanned by means of cone beam computed tomography (CBCT). CBCT analysis was performed in one central and two lateral (mesial and distal) regions of interest (ROI) of each site evaluating the horizontal thickness of the augmented hard tissue (HThard tisue ) and the total thickness of hard and soft tissue (HTtotal ). The Wilcoxon-Pratt signed rank test was used for statistical analysis. RESULTS:In the majority of ROIs, equine and bovine blocks rendered significantly higher values in HThard tissue and HTtotal than controls (P < 0.05). Generally, equine blocks reached the highest values in HThard tissue and HTtotal followed by DBBM blocks and particulate DBBM. The differences in HThard tissue and HTtotal between GBR groups were not statistically significant (P > 0.05). In the central ROI, HThard tissue at the level of the implant shoulder measured 1.7 ± 1.4 mm for equine blocks, 1.7 ± 1.0 mm for DBBM blocks, 0.9 ± 1.2 mm for particulate DBBM, and 0 ± 0 mm for controls. The corresponding values in the lateral ROI reached 1.9 ± 1.1 mm for equine blocks, 1.2 ± 0.8 mm for DBBM blocks, 1.0 ± 0.9 mm for particulate DBBM, and 0 ± 0 mm for controls. CONCLUSIONS:GBR with bone substitute blocks lead to higher ridge dimensions than empty controls. The equine block with CM rendered the most favorable outcomes in hard and soft tissue contours followed by DBBM block and DBBM granulate with CM.

journal_name

Clin Oral Implants Res

journal_title

Clinical oral implants research

authors

Benic GI,Thoma DS,Jung RE,Sanz-Martin I,Unger S,Cantalapiedra A,Hämmerle CHF

doi

10.1111/clr.13011

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

e262-e270

issue

eissn

0905-7161

issn

1600-0501

journal_volume

pub_type

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Guided bone regeneration with particulate vs. block xenogenic bone substitutes: a pilot cone beam computed tomographic investigation.