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[Effects of lidocaine and magnesium sulfate in attenuating hemodynamic response to tracheal intubation: single-center, prospective, double-blind, randomized study].

Abstract：

BACKGROUND AND OBJECTIVES:Hemodynamic response to airway stimuli is a common phenomenon and its management is important to reduce the systemic repercussions. The objective of this study is to compare the efficacy of intravenous magnesium sulfate versus lidocaine on this reflex hemodynamics after laryngoscopy and tracheal intubation. METHODS:This single-center, prospective, double-blind, randomized study evaluated 56 patients ASA 1 or 2, aged 18 to 65 years, scheduled for elective surgeries under general anesthesia with intubation. The patients were allocated into two groups: Group F received 30mg·kg-1 of magnesium sulphate and Group L, 2mg·kg-1 of lidocaine, continuous infusion, immediately before the anesthetic induction. Blood pressure (BP), heart rate (HR), and bispectral index (BIS) were measured in both groups at six different times related to administration of the study drugs. RESULTS:In both groups there was an increase in HR and BP after laryngoscopy and intubation, compared to baseline. Group M showed statistically significant increase in the values of systolic and diastolic blood pressure after intubation, which was clinically unimportant. There was no difference in the BIS values between groups. Among patients receiving magnesium sulfate, three (12%) had high blood pressure versus only one among those receiving lidocaine (4%), with no statistical difference. CONCLUSION:Magnesium sulfate and lidocaine have good efficacy and safety for hemodynamic management in laryngoscopy and intubation.

journal_name

Rev Bras Anestesiol

journal_title

Revista brasileira de anestesiologia

authors

Mendonça FT,de Queiroz LM,Guimarães CC,Xavier AC

doi

10.1016/j.bjan.2016.02.001

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

50-56

issue

1

eissn

0034-7094

issn

1806-907X

pii

S0034-7094(16)00025-8

journal_volume

67

pub_type

杂志文章

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