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Correlation between CSF concentration and side effects after spinal morphine injection in rats.

Abstract：

BACKGROUND AND OBJECTIVES:Spinal morphine promotes good pain relief, but is not free from side effects. This study aimed at verifying the correlation between CSF morphine concentration and side effects. METHODS:This study involved 4 groups of 7 rats, which were studied 24 hours after spinal catheter insertion via cisterna magna. Groups G1, G2, G3 and G4 received respectively 0.1; 0.3; 0.5 and 1 microg morphine in 10 microl of 0.9% saline solution. CSF samples were collected and side effects were recorded at M15, M30, M60, M120 and M180 minutes after injection. RESULTS:Side effects observed were: mandible tremors, agitation, pruritus, absence of diuresis, sedation, and respiratory changes. The incidence of side effects was higher during early evaluations and progressively decreased with time. Mean CSF morphine concentrations in G1 varied from 72.84 to 1.13 pg; in G2 from 114.26 to 5.68 pg; in G3 from 151.18 to 13.62 pg and in G4, from 561.37 to 18.61 pg. CONCLUSIONS:There has been no correlation between CSF morphine concentration and side effects.

journal_name

Rev Bras Anestesiol

journal_title

Revista brasileira de anestesiologia

authors

Silva Nde S,Sakata RK,Issy AM

doi

10.1590/s0034-70942004000100007

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

53-9

issue

1

eissn

0034-7094

issn

1806-907X

pii

S0034-70942004000100007

journal_volume

54

pub_type

杂志文章

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