Clinical characteristics of patients with cerebellar ataxia associated with anti-GAD antibodies.

Abstract:

Methods:This retrospective and descriptive study evaluated the clinical characteristics and outcomes of patients with CA-GAD-ab. Result:Three patients with cerebellar ataxia, high GAD-ab titers and autoimmune endocrine disease were identified. Patients 1 and 2 had classic stiff person syndrome and insidious-onset cerebellar ataxia, while Patient 3 had pure cerebellar ataxia with subacute onset. Patients received intravenous immunoglobulin therapy with no response in Patients 1 and 3 and partial recovery in Patient 2. Conclusion:CA-GAD-ab is rare and its clinical presentation may hamper diagnosis. Clinicians should be able to recognize this potentially treatable autoimmune cerebellar ataxia.

journal_name

Arq Neuropsiquiatr

authors

Aguiar TS,Fragoso A,Albuquerque CR,Teixeira PF,Souza MV,Zajdenverg L,Alves-Leon SV,Rodacki M,Lima MA

doi

10.1590/0004-282X20170011

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

142-146

issue

3

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2017000300142

journal_volume

75

pub_type

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