Abstract:
:The rates of diabetes, obesity, and metabolic disease have reached epidemic proportions worldwide. In recent years there has been renewed interest in combating these diseases not only by modifying energy intake and lifestyle factors, but also by inducing endogenous energy expenditure. This approach has largely been stimulated by the recent recognition that brown adipose tissue (BAT)-long known to promote heat production and energy expenditure in infants and hibernating mammals-also exists in adult humans. This landmark finding relied on the use of clinical fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography, and imaging techniques continue to play a crucial and increasingly central role in understanding BAT physiology and function. Herein, the authors review the origins of BAT imaging, discuss current preclinical and clinical strategies for imaging BAT, and discuss imaging methods that will provide crucial insight into metabolic disease and how it may be treated by modulating BAT activity. (©) RSNA, 2016.
journal_name
Radiologyjournal_title
Radiologyauthors
Sampath SC,Sampath SC,Bredella MA,Cypess AM,Torriani Mdoi
10.1148/radiol.2016150390subject
Has Abstractpub_date
2016-07-01 00:00:00pages
4-19issue
1eissn
0033-8419issn
1527-1315journal_volume
280pub_type
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