Abstract：
BACKGROUND:The last 5 years' studies using next-generation sequencing provided evidences that many types of solid tumors present spatial and temporal genetic heterogeneity and are composed of multiple populations of genetically distinct subclones that evolve over time following a pattern of branched evolution. The evolutionary nature of cancer has been proposed as the major contributor to drug resistance and treatment failure. In this review, we present the current state of knowledge about the clonal evolution of high-grade serous ovarian cancer and discuss the challenge that clonal evolution poses for efforts to achieve an optimal cancer control. METHODS:A systemic search of peer-reviewed articles published between August 2007 and October 2016 was performed using PUBMED and Google Scholar database. RESULTS AND CONCLUSIONS:Recent studies using next-generation sequencing have allowed us to look inside the evolutionary nature of high-grade serous ovarian cancer, which in the light of current evidence can explain the relapsing course of the disease frequently observed in the clinical practice. Since only minimal improvement in the survival of patients treated with standard therapy has been observed in the last decade, novel molecular targeted therapies are of great interest in high-grade serous ovarian cancer. However, both spatial and temporal intratumoral genetic heterogeneity is a major challenge for personalized medicine, and greater knowledge of the molecular rules that drive tumor evolution through space and time is required to achieve a long-term clinical benefit from personalized therapy.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Salomon-Perzyński A,Salomon-Perzyńska M,Michalski B,Skrzypulec-Plinta Vdoi
10.1007/s00404-017-4292-1subject
Has Abstractpub_date
2017-03-01 00:00:00pages
569-576issue
3eissn
0932-0067issn
1432-0711pii
10.1007/s00404-017-4292-1journal_volume
295pub_type
杂志文章,评审abstract：:The objective of the study was to examine the teratogenic potential of surgery under anesthesia during pregnancy in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. An analysis of cases with congenital abnormalities and matched healthy controls was p...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s004040050221
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to examine the effects of of bromocriptin combined with clomiphene citrate in clomiphene-resistant patients with polycystic ovary syndrome and normal prolactin level. DESIGN:Prospective, double-blind, controlled study. SETTING:University teaching hospital. PATIENTS:One hundred...
journal_title：Archives of gynecology and obstetrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00404-002-0437-x
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:Total laparoscopic hysterectomy (TLH) in the case of endometriosis may be extremely challenging. Our aim has been to analyze perioperative details and complications of TLH in women with vs. women without endometriosis. METHODS:Consecutive women who underwent TLH for endometriosis (endometriosis group) were com...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-016-4115-9
更新日期：2016-10-01 00:00:00
abstract：:Tubal sterilization is one of the options chosen by the women who have completed their fertility. Although ectopic pregnancy after tubal sterilization is rare, all women undergoing this procedure should be informed about the risk of it. An ectopic pregnancy in a 36-year-old woman who had undergone tubal sterilization ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/pl00007502
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To characterize the indications for preterm delivery and identify risk factors predicting preterm delivery in pregnancies complicated by pregestational diabetes (PGDM). STUDY DESIGN:A retrospective cohort study of all women with type 1 or type 2 diabetes mellitus followed from preconception to delivery at ou...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0541-z
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:Low levels of plasmatic pregnancy-associated plasma protein-A (PAPP-A) and high levels of free-beta human chorionic gonadotropin (beta-hCG) could influence the outcome of pregnancy. The objective of this study is to assess the correlation between PAPP-A and free beta-hCG and birth weight. MATERIALS AND METHODS...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-015-3947-z
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:To analyze the effect of Chlamydia trachomatis (C. trachomatis) on adverse pregnancy outcomes based on the currently available evidence. METHODS:Multiple databases were comprehensively searched from the available date of inception through December 9, 2019. The effect of C. trachomatis on adverse pregnancy outc...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00404-020-05664-6
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To identify the optimal time for the frozen embryo transfer (FET) after oocyte retrieval in freeze-all cycles. METHODS:A retrospective analysis of 977 patients was performed. Implantation, clinical pregnancy and live birth rates were analyzed. RESULTS:No significant difference was found between the first FET ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05405-4
更新日期：2020-01-01 00:00:00
abstract：AIM:To evaluate postoperative sexual functioning and the influence of patients' expectations on the change in sexuality following laparoscopic total (TLH) versus subtotal hysterectomy (LASH). METHODS:A total of 120 women undergoing laparoscopic hysterectomy were preoperatively enrolled in this bicentric prospective st...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-018-4812-7
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To compare the effectiveness of intravenous carbetocin to that of intravenous oxytocin for prevention of atonic postpartum hemorrhage (PPH) after vaginal delivery in high-risk singleton pregnancies. METHODS:This triple-blind randomized controlled trial included singleton pregnant women who delivered at Siriraj...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-018-4806-5
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:This prospective study investigated associations between prenatal attachment of adult first-time mothers to the unborn child, perinatal factors and levels of depression before and up to 18 months after delivery. METHOD:Primiparas (N = 161) without specific risk factors answered the following questionnaires dur...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-012-2286-6
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Many studies have shown that changes in the weather affect health. In the field of obstetrics and gynecology, several events have been empirically shown to be related to the weather. Labor pain is controlled by the autonomic nervous system and various hormones, and is expected to be influenced by the weather...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-006-0259-3
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women wit...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-018-4884-4
更新日期：2018-11-01 00:00:00
abstract：:We here report a case of trisomy 21 with congenital chylothorax. The patient was a male newborn who had been diagnosed as having trisomy 21 with congenital chylothorax. This is the fifth case of the both conditions in English literature. Congenital chylothorax is very rare in a trisomy 21 patient. There, however, may ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02389608
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:To investigate the frequency of ruptured uterus, possible etiologic factors and fetomaternal outcomes. STUDY DESIGN:A retrospective chart view of all patients with ruptured uterus over a 9-year period from 1995 to 2003 was carried out. Relevant data relating to the clinical features, characteristics of labou...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-005-0733-3
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Angioleiomyoma is a rare benign solitary tumor, arising from the vascular smooth muscle. This tumor usually occurs in the subcutis of extremities, uncommonly in abdomen, often presents as a small (<2 cm) and is treated with excision. CASE:We report an extremely rare case of unusually large angioleiomyoma, f...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0663-y
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:To compare the sensitivity, specificity, positive and negative predictive values and accuracy of visual inspection with acetic acid under magnification (VIAM) and colposcopy for detecting cervical intraepithelial neoplasia (CIN) to determine if VIAM can substitute colposcopy in identifying the biopsy site in sc...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1673-0
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:The first part of the study involved data collection for the detection of geographic variations and chronologic fluctuations in the rates of shoulder dystocia. The second part of the research evaluated head-to-body delivery times in cases of arrest of the shoulders at birth that had resulted in fetal damage dur...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3453-8
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Transversus abdominis plane (TAP) block has been shown to provide pain relief after abdominal procedures. However, TAP block combined with multimodal analgesia technique have not been assessed in a randomized controlled trial. This randomized, controlled, observer-blinded study was designed to evaluate the a...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-012-2698-3
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:Our objective was to review the hysterectomies performed in our clinic for the last 17 years to reveal the facts in relation to the operation. MATERIALS AND METHODS:The records of the patients who had undergone hysterectomy in Istanbul University Cerrahpasa School of Medicine Department of Obstetrics and Gyn...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-003-0546-1
更新日期：2004-12-01 00:00:00
abstract：:Intestinal obstruction in pregnancy is rare and difficult to diagnose. Common causes of gestational intestinal obstruction include adhesions, volvulus, intussuscetion, carcinoma, hernia and appendicitis [3]. Abdominal pain is a common feature, but the displacement of abdominal organs as pregnancy progresses results in...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-005-0097-8
更新日期：2006-04-01 00:00:00
abstract：CASE REPORT:The authors presented a rare case of acute abdomen syndrome caused by the rupture of the corpus rubrum as the first symptom in a 35-years-old woman with the acute lymphatic leukemia. During the laparotomy is notice diffuse bleeding from under skin blood vessels and muscles. The blood was electrocoagulated a...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-002-0453-x
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:The Nitric Oxide (NO) system plays an important role in the establishment and maintenance of the feto-placental circulation. Research on the pathogenesis of preeclampsia in several studies has established the involvement of the NO-system in preeclampsia and fetal intrauterine growth restriction (IUGR). In th...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-006-0149-8
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Often, internet can bring a sense of anxiety rather than information and understanding to the patient. Our aim was to assess the quality of information available for patients on the management of polycystic ovarian syndrome (PCOS) on the internet. MATERIALS AND METHODS:Five search engines were searched usin...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-010-1378-4
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To assess the impact of pre-hCG elevated progesterone on live birth outcomes during GnRH agonist long down regulated protocol assisted reproduction cycles. DESIGN:Retrospective cohort study. SETTING:Single Centre Private IVF Clinic. PATIENTS:A total of 582 consecutive cycles of IVF/ICSI in 2003. INTERVENT...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-2045-0
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:To investigate the influence of different kinds of endometriotic lesions, especially peritoneal endometriotic implants in pain generation and the pain reduction after surgical excision in a prospective study. METHODS:Fifty-one pre-menopausal patients underwent surgical laparoscopy due to chronic pelvic pain, d...
journal_title：Archives of gynecology and obstetrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00404-008-0921-z
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:To evaluate the benefit of the intraoperative use of a cell salvage and autologous blood recovery system during laparoscopic myomectomy (LM). METHODS:We retrospectively reviewed the medical records of 538 patients who underwent LM between January 2008 and December 2009 at our hospital. Patients undergoing LM w...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-2118-0
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVES:The influence a job--including its physical and psychological aspects--has on pregnant woman's chances of delivering prematurely. METHODS:Seven hundred and seven women who had given birth participated. Statements regarding her job and its stresses were obtained with a standardised questionnaire. RESULTS:Tw...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00404-003-0487-8
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:This study aimed to determine the relationship between spousal deployment and postpartum depression diagnosis among U.S. military wives, accounting for the timing of deployment with respect to pregnancy and delivery. METHODS:A retrospective cohort study was conducted to evaluate the association between spous...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-015-3672-7
更新日期：2015-09-01 00:00:00
abstract：INTRODUCTION:Worldwide, 20-30 million people are estimated to be infected with HTLV. HTLV-1 is endemic in Western Africa and Southern Japan, whereas HTLV-2 is considered to be spread among native American people. MATERIALS AND METHODS:The impact of HTLV in gynaecology and obstetrics is being reviewed. Search strategy ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-010-1559-1
更新日期：2010-11-01 00:00:00
