Abstract:
OBJECTIVE:The aim of this study was to evaluate the effect of two different doses of dexpanthenol (Dxp) onexperimentally induced ovarian ischaemia/reperfusion (I/R) injury ina rat model. STUDY DESIGN:Forty female rats were randomly divided into fivegroups: Group 1: sham operation; Group 2: 3-h ischaemia; Groups 3: 3-h ischaemia, 3-h reperfusion (I/R); Group 4: I/R + 300 mg/kg Dxp intraperitoneally (i.p) Group 5: I /R + 500 mg/kg Dxpi.p. Total anti-oxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), tissue malondialdehyde (MDA) and activities of glutathione peroxidase and catalase were calculated. Ovarian tissue damage was assessed using a histopathological scoring system. RESULTS:The TOS and OSI values were significantly lower in Group 5, as compared to Groups 2 and 3 (p < 0.05). The MDA levels in Group 1 and Group 5 were significantly lower than those in Group 3 (p < 0.05). CAT and GSH-Px activity was higher in Group 5 than in Group 2 and Group 3 (p = 0.00). Tissue damage scores were elevated in all the groups compared with sham group, but the treatment with the different doses of Dxp before reperfusion ameliorated the tissue damage scores. CONCLUSION:The results showed that Dxp reduced ovarian I/R injury.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Soylu Karapinar O,Pinar N,Özcan O,Atik Doğan E,Bayraktar S,Şahin H,Dolapçioğlu Kdoi
10.1007/s00404-017-4287-ysubject
Has Abstractpub_date
2017-03-01 00:00:00pages
777-784issue
3eissn
0932-0067issn
1432-0711pii
10.1007/s00404-017-4287-yjournal_volume
295pub_type
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