PIWIL2 is overexpressed in adenomyotic lesions of women with diffuse adenomyosis.

Abstract:

PURPOSE:Adenomyosis has been studied throughout the years, however, its aetiology and physiopathology are still unknown. The aim of this study was to identify the presence of PIWI proteins in women with adenomyosis. METHODS:We included 72 participants to be part of this study and were divided into two groups based on their anatomopathological diagnosis, control (n = 36) or adenomyosis (n = 36). All samples were tested for PIWIL1, PIWIL2 and PIWIL4 proteins by immunohistochemistry. The evaluation of protein expression was performed by the digital histological score (DHSCORE) and by the pathologist's analysis. RESULTS:The participants had a mean age of 44.28 ± 5.76 years and 45.81 ± 4.86 years in the control and adenomyosis groups, respectively (p ≥ 0.05). Other clinical characteristics of the participants showed no statistical difference as well. PIWIL2 is highly expressed in the adenomyosis in comparison to the control group (p = 0.0001). The PIWIL1 is downregulated in the adenomyosis (p = 0.003) and PIWIL4 showed no difference in its expression (p = 0.05). CONCLUSION:PIWIL2 might be involved in cellular survival and PIWIL1 may be downregulated due to the loss of tissue's function and response to the hostile environment of the myometrium. This is the first time that PIWI proteins are studied in the adenomyosis.

journal_name

Arch Gynecol Obstet

authors

Mattia MMC,Fernandes ACP,Genro VK,de Souza CAB,da Rocha Olsen P,Cunha-Filho JS

doi

10.1007/s00404-020-05660-w

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

925-933

issue

4

eissn

0932-0067

issn

1432-0711

pii

10.1007/s00404-020-05660-w

journal_volume

302

pub_type

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