Usefulness of procalcitonin level as an outcome predictor of adult bacterial meningitis.

Abstract:

:Acute bacterial meningitis is rare, but can be fulminant unless rapidly evaluated and treated. The aim of this study was to evaluate whether serum procalcitonin (PCT) levels could predict unfavorable outcomes of bacterial meningitis. We retrospectively reviewed the medical records of 604 meningitis patients from the emergency department (ED) of our tertiary care, university-affiliated hospital over a five-year period. We analyzed the ability of blood PCT levels on admission to predict the outcome at discharge (defined as Glasgow Outcome Scale scores of 1-4). Of 71 patients with acute bacterial meningitis, 28 (39 %) experienced an unfavorable outcome at discharge (overall mortality: 5 %). The serum PCT level at admission was a predictive indicator of an unfavorable outcome [adjusted odds ratio: 1.04, 95 % confidence interval (CI) 1.01-1.09, p = 0.05]. As assessed using receiver operating characteristic curves for an unfavorable outcome, the area under the PCT curve was 0.708 (95 % CI 0.58-0.84, p < 0.01). When the PCT cutoff value was ≥1.10 ng/mL, the sensitivity, specificity, positive predictive value and negative predictive value for an unfavorable outcome were 75, 70, 62, and 81 %, respectively. An association between the serum PCT level and an unfavorable outcome is observed.

journal_name

Intern Emerg Med

authors

Ko BS,Ryoo SM,Ahn S,Sohn CH,Seo DW,Kim WY

doi

10.1007/s11739-016-1509-4

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

1003-1009

issue

7

eissn

1828-0447

issn

1970-9366

pii

10.1007/s11739-016-1509-4

journal_volume

12

pub_type

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