Usefulness of procalcitonin level as an outcome predictor of adult bacterial meningitis.


:Acute bacterial meningitis is rare, but can be fulminant unless rapidly evaluated and treated. The aim of this study was to evaluate whether serum procalcitonin (PCT) levels could predict unfavorable outcomes of bacterial meningitis. We retrospectively reviewed the medical records of 604 meningitis patients from the emergency department (ED) of our tertiary care, university-affiliated hospital over a five-year period. We analyzed the ability of blood PCT levels on admission to predict the outcome at discharge (defined as Glasgow Outcome Scale scores of 1-4). Of 71 patients with acute bacterial meningitis, 28 (39 %) experienced an unfavorable outcome at discharge (overall mortality: 5 %). The serum PCT level at admission was a predictive indicator of an unfavorable outcome [adjusted odds ratio: 1.04, 95 % confidence interval (CI) 1.01-1.09, p = 0.05]. As assessed using receiver operating characteristic curves for an unfavorable outcome, the area under the PCT curve was 0.708 (95 % CI 0.58-0.84, p < 0.01). When the PCT cutoff value was ≥1.10 ng/mL, the sensitivity, specificity, positive predictive value and negative predictive value for an unfavorable outcome were 75, 70, 62, and 81 %, respectively. An association between the serum PCT level and an unfavorable outcome is observed.


Intern Emerg Med


Ko BS,Ryoo SM,Ahn S,Sohn CH,Seo DW,Kim WY




Has Abstract


2017-10-01 00:00:00














  • Safety and effectiveness of biosimilar enoxaparin (Inhixa) for the prevention of thromboembolism in medical and surgical inpatients.

    abstract::In 2016, biosimilar enoxaparin (Inhixa®, Techdow) was introduced in European markets with the same indications as branded enoxaparin (Clexane®, Sanofi). Its use is constantly increasing in clinical practice, however, little information from post-marketing clinical trials is available on its safety and effectiveness. W...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Fantoni C,Bertù L,Faioni EM,Froiio C,Mariani N,Ageno W

    更新日期:2020-10-27 00:00:00

  • Italian intersociety consensus on DOAC use in internal medicine.

    abstract::The direct oral anticoagulants (DOACs) are drugs used in clinical practice since 2009 for the prevention of stroke or systemic embolism in non-valvular atrial fibrillation, and for the treatment and secondary prevention of venous thromboembolism. The four DOACs, including the three factor Xa inhibitors (rivaroxaban, a...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Prisco D,Ageno W,Becattini C,D'Angelo A,Davì G,De Cristofaro R,Dentali F,Di Minno G,Falanga A,Gussoni G,Masotti L,Palareti G,Pignatelli P,Santi RM,Santilli F,Silingardi M,Tufano A,Violi F,SIMI (Italian Society of Inte

    更新日期:2017-04-01 00:00:00

  • Cardiovascular and metabolic risks associated with PCOS.

    abstract::Polycystic ovary syndrome, the most common endocrine disorder of reproductive age women, is often associated with insulin resistance and associated disorders. The frequency of type 2 diabetes, hyperlipidemia, cardiac risk markers, structural vascular disease, and clinical disease events are increased in this populatio...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Cobin RH

    更新日期:2013-04-01 00:00:00

  • Association between hemoglobin levels and clinical outcomes in adult patients after in-hospital cardiac arrest: a retrospective cohort study.

    abstract::In addition to cardiac output, oxygen delivery is determined by the amount of oxygen carried by hemoglobin, which is estimated by the product of hemoglobin level and peripheral hemoglobin oxygen saturation (SpO2). Optimal hemoglobin concentration for post-cardiac arrest syndrome (PCAS) has not yet been investigated th...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Wang CH,Huang CH,Chang WT,Tsai MS,Yu PH,Wang AY,Chen NC,Chen WJ

    更新日期:2016-08-01 00:00:00

  • Non-alcoholic fatty liver disease and cardiovascular disease: epidemiological, clinical and pathophysiological evidences.

    abstract::Non-alcoholic fatty liver disease is recognized as the most common and emerging chronic liver disease in western countries. The disease has been traditionally interpreted as a possibly progressing condition to liver fibrosis and cirrhosis. However, recently, a large number of publications have demonstrated that people...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Del Ben M,Baratta F,Polimeni L,Angelico F

    更新日期:2012-10-01 00:00:00

  • Early invasive strategy and outcomes of non-ST-elevation acute coronary syndrome patients: is time really the major determinant?

    abstract::In non-ST-elevation acute coronary syndromes (ACS), an early invasive strategy is recommended for middle/high-risk patients; however, the optimal timing for coronary angiography is still debated. The aim of this study was to evaluate the prognostic implications of the time of angiography in ACS patients treated in acc...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Giglioli C,Cecchi E,Landi D,Valente S,Chiostri M,Romano SM,Spini V,Perrotta L,Simonetti I,Gensini GF

    更新日期:2013-03-01 00:00:00

  • Evaluation of community-acquired sepsis by PIRO system in the emergency department.

    abstract::The predisposition, infection/insult, response, and organ dysfunction (PIRO) staging system for septic patients allows grouping of heterogeneous patients into homogeneous subgroups. The purposes of this single-center, prospective, observational cohort study were to create a PIRO system for patients with community-acqu...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Chen YX,Li CS

    更新日期:2013-09-01 00:00:00

  • Chronic kidney disease and kidney health care status: the healthy life in Suriname (HeliSur) study.

    abstract::The high cardiovascular risk burden in low- and middle-income countries is expected to lead to an explosive increase in chronic kidney disease (CKD). However, population data on CKD from these countries are scarce. Therefore, we assessed kidney health in Suriname. In the Healthy Life in Suriname (HeliSur) study, a ran...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Nannan Panday R,Haan Y,Diemer F,Punwasi A,Rommy C,Heerenveen I,van Montfrans GA,Brewster LM

    更新日期:2019-03-01 00:00:00

  • Anticoagulant therapy in the treatment of splanchnic vein thrombosis associated to acute pancreatitis: a 3-year single-centre experience.

    abstract::Splanchnic vein thrombosis (SVT) is a possible complication of acute pancreatitis (AP). There are no precise guidelines on the use of anticoagulant therapy (AT) in these patients. The aim of the study was to determine the safety and the efficacy of AT in AP-associated SVT. Two hundred twenty-one patients were retrospe...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Pagliari D,Cianci R,Brizi MG,Mancarella FA,Musso M,Cintoni M,Franza L,Flore RA,Gasbarrini A,Tondi P

    更新日期:2020-09-01 00:00:00

  • Effects of cryoablation and radiofrequency ablation on endothelial and blood clotting activation.

    abstract::Cryoablation (CA) emerged as an alternative procedure to radiofrequency (RF). The aim of this study was to compare haemostatic system alterations in patients undergoing RF or CA for atrioventricular nodal reentrant tachycardia ablation. von Willebrand factor (vWF), spontaneous whole blood platelet aggregation, prothro...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Pieragnoli P,Gori AM,Ricciardi G,Carrassa G,Checchi L,Michelucci A,Priora R,Cellai AP,Marcucci R,Padeletti L,Abbate R

    更新日期:2014-12-01 00:00:00

  • Etomidate use in severe sepsis and septic shock patients does not contribute to mortality.

    abstract::Use of etomidate in severe sepsis and septic shock has been challenged in recent literature due to its link to adrenal insufficiency and suspected increased mortality. We hypothesized that etomidate does not contribute to mortality in this patient population. A retrospective chart review of 230 intubated, severe sepsi...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Ehrman R,Wira C,Lomax A,Hayward A,Marcelin J,Ellis T,Przyklenk K,Volturo G,Mullen M

    更新日期:2011-06-01 00:00:00

  • The management of patients with venous thromboembolism in Italy: insights from the PREFER in VTE registry.

    abstract::Venous thromboembolism (VTE) is the third most common cardiovascular disease. Real-life data on the clinical presentation, risk factors, diagnosis, and treatment of VTE in Italy and Europe are required to optimize the management of this disease. The PREFER in VTE registry, a prospective non-interventional real-life st...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Guercini F,Mommi V,Camporese G,Tonello C,Imberti D,Benedetti R,De Bartolomeo G,Di Lecce L,Romeo F,Agnelli G

    更新日期:2016-12-01 00:00:00

  • Six minute walk test: a simple and useful test to evaluate functional capacity in patients with heart failure.

    abstract::In heart failure survival is closely related to functional capacity. Peak O2 consumption at cardiopulmonary exercise test (CPET) is considered the gold standard for the evaluation of exercise tolerance. Since >70% of patients with heart failure, usually elderly or with significant comorbidities, are referred to Depart...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Rostagno C,Gensini GF

    更新日期:2008-09-01 00:00:00

  • Hospital length-of-stay and costs among pulmonary embolism patients treated with rivaroxaban versus parenteral bridging to warfarin.

    abstract::We sought to compare length-of-stay (LOS), total hospital costs, and readmissions among pulmonary embolism (PE) patients treated with rivaroxaban versus parenterally bridged warfarin. We identified adult PE (primary diagnostic code = 415.1x) patients in the Premier Database (11/2012-9/2015), and included those with ≥1...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Weeda ER,Wells PS,Peacock WF,Fermann GJ,Baugh CW,Ashton V,Crivera C,Wildgoose P,Schein JR,Coleman CI

    更新日期:2017-04-01 00:00:00

  • Is echocardiography mandatory for patients with chronic kidney disease?

    abstract::This study aims at evaluating the prevalence of left ventricular diastolic dysfunction in a group of 319 hypertensive patients with stage 3b-4-5 chronic kidney disease (according to Kidney Disease Improving Global Outcomes classification), compared with 216 patients with essential hypertension and normal renal functio...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Nardi E,Mulè G,Nardi C,Geraci G,Giammanco A,Bentivegna R,Averna M

    更新日期:2019-09-01 00:00:00

  • Brain natriuretic peptide as a preclinical marker of chronic pulmonary hypertension in patients with pulmonary embolism.

    abstract::Chronic thromboembolic pulmonary hypertension (CTPH) is a potential complication of pulmonary embolism (PE). Only few studies have assessed the role of brain natriuretic peptide (BNP) in patients with chronic pulmonary hypertension, and there are no data on the potential utility of BNP as a preclinical biomarker of CT...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Dentali F,Donadini M,Gianni M,Bertolini A,Lonn E,Venco A,Cattozzo G,Ageno W

    更新日期:2009-04-01 00:00:00

  • The effect of management models on thromboembolic and bleeding rates in anticoagulated patients: an ecological study.

    abstract::The primary study objective is to compare the outcomes of patients taking oral anticoagulant medications in two distinct populations treated according to different management models (comprehensive vs. usual care). (Design: regional prospective cohort study; setting: hospital admission data from two regions). Eligible ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Tosetto A,Testa S,Palareti G,Paoletti O,Nichele I,Catalano F,Morandini R,Di Paolo M,Tala M,Esteban P,Cora' F,Mannino S,Maroni A,Sessa M,Castaman G

    更新日期:2019-11-01 00:00:00

  • Physician in triage improves emergency department patient throughput.

    abstract::To determine if a physician in triage (PIT) improves Emergency Department (ED) patient flow in a community teaching hospital. This is an interventional study comparing patient flow parameters for the 3-month periods before and after implementation of a PIT model. During the interventional time an additional attending ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Imperato J,Morris DS,Binder D,Fischer C,Patrick J,Sanchez LD,Setnik G

    更新日期:2012-10-01 00:00:00

  • Clinical features of 1487 COVID-19 patients with outpatient management in the Greater Paris: the COVID-call study.

    abstract::Clinical features of COVID-19 have been mostly described in hospitalized patients with and without ICU admission. Yet, up to 80% of patients are managed in an outpatient setting. This population is poorly documented. In France, health authorities recommend outpatient management of patients presenting mild-to-moderate ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Lapostolle F,Schneider E,Vianu I,Dollet G,Roche B,Berdah J,Michel J,Goix L,Chanzy E,Petrovic T,Adnet F

    更新日期:2020-08-01 00:00:00

  • Inadequate cancer pain management in Italian clinical trials.

    abstract::Pain treatment in Italy is far from being optimal. In order to improve this situation, the reporting of a complete assessment of pain in the clinical record became compulsory by law. Pain-related cancer protocols (143) were selected from the National Monitoring Centre of Clinical Trials Database and reviewed. Our data...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Lucenteforte E,Maggini V,Maione R,Fabbroni V,Tomino C,Mugelli A

    更新日期:2013-10-01 00:00:00

  • Treatment outcome in a cohort of young patients with polycythemia vera.

    abstract::The treatment of polycythemia vera in young adults is challenging, requiring one to run a balance between the increased risk of vascular complications, if left untreated, versus the potential of promoting secondary leukemia/myelodysplasia or cancer, if actively managed with chemotherapy. We report the results of a 20-...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Ruggeri M,Finotto S,Fortuna S,Rodeghiero F

    更新日期:2010-10-01 00:00:00

  • Drug-drug interactions in patients with acute coronary syndrome across phases of treatment.

    abstract::The objective of this study is to evaluate potential drug-drug interactions (pDDIs) and risk factors for pDDIs in three phases of an acute coronary syndrome (ACS) treatment: from the point of first medical contact to the coronary angiography (first phase), after coronary angiography to the last day of hospitalization ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Pejčić AV,Janković SM,Davidović G

    更新日期:2019-04-01 00:00:00

  • A narrative review of coronavirus disease 2019 (COVID-19): clinical, epidemiological characteristics, and systemic manifestations.

    abstract::Coronavirus disease 2019 (COVID-19) is an emerging infectious disease which has had a rapid surge in cases and deaths since it is first documented in Wuhan, China, in December 2019. COVID-19 is caused by the Betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses angiotensin-conve...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Krishnan A,Hamilton JP,Alqahtani SA,A Woreta T

    更新日期:2021-01-16 00:00:00

  • Halitosis: could it be more than mere bad breath?

    abstract::Halitosis is a generic term used to describe unpleasant odor emanating from the mouth air and breath, independent of the source where the odor substances originate. It affects between 50 and 65% of the population, but despite its frequency, this problem is often unaccepted and declared as taboo. Ninety percent of pati...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审


    authors: Campisi G,Musciotto A,Di Fede O,Di Marco V,Craxì A

    更新日期:2011-08-01 00:00:00

  • Amiodarone-related thyroid dysfunction.

    abstract::Nowadays, amiodarone is the most commonly used antidysrhythmic drug in clinical practice. It is highly effective in the management of recurrent ventricular dysrhythmias, paroxysmal supraventricular dysrhythmias, including atrial fibrillation and flutter, and in the maintenance of sinus rhythm after electrical cardiove...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Hudzik B,Zubelewicz-Szkodzinska B

    更新日期:2014-12-01 00:00:00

  • Quality of life impairment in Behçet's disease and relationship with disease activity: a prospective study.

    abstract::Our aim was to prospectively investigate the impact of Behçet's disease (BD), disease activity, and clinical and demographic characteristics on different aspects of quality of life (QoL) measured by the short-form (SF)-36 QoL scale. We administered the SF-36 to 37 consecutive BD patients in different moments of diseas...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Fabiani C,Vitale A,Orlando I,Sota J,Capozzoli M,Franceschini R,Galeazzi M,Tosi GM,Frediani B,Cantarini L

    更新日期:2017-10-01 00:00:00

  • Noninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients.

    abstract::Auto-titrating noninvasive ventilation (NIV) has been developed as a new mode applying variable expiratory-positive airway pressure (EPAP) in addition to variable inspiratory pressures (IPAP), both to deliver targeted tidal volume (VT) and to eliminate upper airway resistance. The purpose of this study is to evaluate ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Gursel G,Zerman A,Basarik B,Gonderen K,Aydogdu M,Memmedova S

    更新日期:2018-04-01 00:00:00

  • The incidence and significance of acute kidney injury following emergent contrast administration in patients with STEMI and stroke.

    abstract::The authors have investigated the incidence of acute kidney injury (AKI) and short-term mortality following an activated STEMI and stroke alert at a tertiary referral and academic center. A single center, retrospective chart review of STEMI and stroke activation patients from January 2010 to March 2012. Data was colle...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Marchick MR,Allen BR,Weeks EC,Shuster JJ,Elie MC

    更新日期:2016-09-01 00:00:00

  • Salt and water imbalance in chronic heart failure.

    abstract::In chronic heart failure (CHF), neurohumoral systems, which help to maintain circulatory homeostasis, are maladaptive and responsible for disease progression and congestion in the long term. The activation of sympathetic hormones and renin-angiotensin-aldosterone system (RAAS), in addition to non-osmotic vasopressin r...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章


    authors: Parrinello G,Torres D,Paterna S

    更新日期:2011-10-01 00:00:00

  • Overcrowding in emergency department: an international issue.

    abstract::Overcrowding in the emergency department (ED) has become an increasingly significant worldwide public health problem in the last decade. It is a consequence of simultaneous increasing demand for health care and a deficit in available hospital beds and ED beds, as for example it occurs in mass casualty incidents, but a...

    journal_title:Internal and emergency medicine

    pub_type: 社论


    authors: Di Somma S,Paladino L,Vaughan L,Lalle I,Magrini L,Magnanti M

    更新日期:2015-03-01 00:00:00