Abstract:
:Acute bacterial meningitis is rare, but can be fulminant unless rapidly evaluated and treated. The aim of this study was to evaluate whether serum procalcitonin (PCT) levels could predict unfavorable outcomes of bacterial meningitis. We retrospectively reviewed the medical records of 604 meningitis patients from the emergency department (ED) of our tertiary care, university-affiliated hospital over a five-year period. We analyzed the ability of blood PCT levels on admission to predict the outcome at discharge (defined as Glasgow Outcome Scale scores of 1-4). Of 71 patients with acute bacterial meningitis, 28 (39 %) experienced an unfavorable outcome at discharge (overall mortality: 5 %). The serum PCT level at admission was a predictive indicator of an unfavorable outcome [adjusted odds ratio: 1.04, 95 % confidence interval (CI) 1.01-1.09, p = 0.05]. As assessed using receiver operating characteristic curves for an unfavorable outcome, the area under the PCT curve was 0.708 (95 % CI 0.58-0.84, p < 0.01). When the PCT cutoff value was ≥1.10 ng/mL, the sensitivity, specificity, positive predictive value and negative predictive value for an unfavorable outcome were 75, 70, 62, and 81 %, respectively. An association between the serum PCT level and an unfavorable outcome is observed.
journal_name
Intern Emerg Medjournal_title
Internal and emergency medicineauthors
Ko BS,Ryoo SM,Ahn S,Sohn CH,Seo DW,Kim WYdoi
10.1007/s11739-016-1509-4subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1003-1009issue
7eissn
1828-0447issn
1970-9366pii
10.1007/s11739-016-1509-4journal_volume
12pub_type
杂志文章abstract::General concepts about medical disasters, public health and triage are outlined. Triage is described in the context of public health emergencies and disaster settings, and the main ethical values at stake in triage are discussed. Possible conflicts between competing values are outlined. Special attention is given to p...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
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abstract::Septic arthritis (SA) is commonly associated with Staphylococcal or Streptococcal infections. Overtime, there has been a global increase in the distribution of antimicrobial resistance within both Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria such as exten...
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journal_title:Internal and emergency medicine
pub_type: 杂志文章,已发布勘误
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更新日期:2018-08-01 00:00:00
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journal_title:Internal and emergency medicine
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abstract::Over the past 50 years, the prevalence of Helicobacter pylori infection has fallen as standards of living improved. The changes in the prevalence of infection and its manifestations (peptic ulcer disease and gastric mucosal lesions) were investigated in a large cohort of Sardinians undergoing upper endoscopy for dyspe...
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更新日期:2018-12-01 00:00:00
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journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-04-01 00:00:00
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journal_title:Internal and emergency medicine
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journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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journal_title:Internal and emergency medicine
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更新日期:2021-01-05 00:00:00
abstract::Ulcerative colitis, one of the two main forms of inflammatory bowel disease, is characterized by inflammation of the large bowel with constant involvement of the rectum, and a possible continuous retrograde distribution up to the cecum. Typical macroscopic lesions are mucosal ulcerations, with immune cell infiltration...
journal_title:Internal and emergency medicine
pub_type: 杂志文章,评审
doi:10.1007/s11739-011-0719-z
更新日期:2012-04-01 00:00:00