Abstract:
:A Y-chromosome-specific in situ hybridization assay was used to assess the frequency with which host bone marrow cells are retained after marrow grafting. The majority of patients (74%) showed the presence of both host and donor marrow cells when assayed 14 days after transplant. By 84 days posttransplant only 4% of the patients retained host marrow cells. Only 1 of 19 evaluable patients analyzed over 1 year posttransplant showed minimal retention of host cells. No statistical correlation was found between retention of host cells posttransplant and the development of relapse or acute or chronic graft-versus-host disease. Pretransplant conditioning regimen, HLA-matching, diagnosis, disease status at transplant, ABO-matching, and patient age also showed no correlation with the retention of host cells posttransplant.
journal_name
Bloodjournal_title
Bloodauthors
Durnam DM,Anders KR,Fisher L,O'Quigley J,Bryant EM,Thomas EDsubject
Has Abstractpub_date
1989-11-01 00:00:00pages
2220-6issue
6eissn
0006-4971issn
1528-0020journal_volume
74pub_type
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