Genetic polymorphisms of PPAR gamma, arsenic methylation capacity and breast cancer risk in Mexican women.

Abstract:

OBJECTIVE:To evaluate whether the presence of polymorphisms of peroxisome proliferator-activated receptor gamma PPARγ (Pro 1 2Ala) and PPARGC1B (Ala203Pro) modifies the association between the inorganic arsenic (iAs) methylation capacity and breast cancer (BC). MATERIALS AND METHODS:Mexican women were interviewed, and blood and urine samples were collected from them (cases/controls= 197/220). The concentration of urinary arsenic species and the polymorphisms of interest were determined by high-performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and polymerase chain reaction (PCR), respectively. RESULTS:In women with a high %MMA (urinary monomethyl arsenic) and high primary methylation ratio (PM = MMA/iAs), the risk of BC was increased (odds ratio [OR]%MMA T3 vs.T1= 3.60: 95% confidence interval [CI] 2.02-6.41, ORPMI T3 vs.T1= 3.47: 95%CI 1.95-6.17), which was maintained after adjusting for polymorphisms. No significant interactions were observed between the polymorphisms and the arsenic variables on the risk of BC. CONCLUSION:Pro 12Ala and Ala203Pro polymorphisms did not modify the association between the iAs methylation capacity and BC.

journal_name

Salud Publica Mex

journal_title

Salud publica de Mexico

authors

Pineda-Belmontes CP,Hernández-Ramírez RU,Hernández-Alcaraz C,Cebrián ME,López-Carrillo L

doi

10.21149/spm.v58i2.7791

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

220-7

issue

2

eissn

0036-3634

issn

1606-7916

pii

S0036-36342016000200220

journal_volume

58

pub_type

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