Collapsing glomerulopathy is common in the setting of thrombotic microangiopathy of the native kidney.

abstract：:Transforming growth factor-β1 (TGF-β1) upregulation occurs in virtually all chronic kidney diseases and is associated with podocyte injury and proteinuria; however, the mechanisms contributing to this in vivo are ambiguous. In vitro, incubation of podocytes with TGF-β1 induced Wnt1 expression, β-catenin activation, an...

journal_title：Kidney international

authors： Wang D,Dai C,Li Y,Liu Y

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Transforming growth factor-beta (TGF-beta) is known to play a pivotal role in the regulation of extracellular matrix (ECM) accumulation. Since diabetic nephropathy (DMN) is characterized by basement membrane thickening and mesangial expansion, control of ECM deposition is believed to be important in the pa...

journal_title：Kidney international

authors： Wong TY,Poon P,Chow KM,Szeto CC,Cheung MK,Li PK

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive ...

journal_title：Kidney international

authors： Hellmark T,Segelmark M,Unger C,Burkhardt H,Saus J,Wieslander J

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques ...

journal_title：Kidney international

authors： Thongboonkerd V,McLeish KR,Arthur JM,Klein JB

更新日期：2002-10-01 00:00:00

abstract：:Murine double minute (MDM)-2, an E3 ubiquitin ligase, promotes cancer cell survival and growth, by degrading the cell cycle regulator p53. Antagonism of MDM2 by the small-molecule cis-imidazoline nutlin analogs is under current study for cancer therapy. To test whether MDM2 also promotes regenerative cell growth, we d...

journal_title：Kidney international

authors： Mulay SR,Thomasova D,Ryu M,Anders HJ

更新日期：2012-06-01 00:00:00

abstract：:The international guideline from Kidney Disease: Improving Global Outcomes suggests a hemoglobin target of 11 to 12 g/dl for children with chronic kidney disease. However, information to support this proposal is very limited in the pediatric population. Because of controversy, the unmet need is the establishment of an...

journal_title：Kidney international

authors： Hattori M

更新日期：2017-01-01 00:00:00

abstract：:Chronic inflammation contributes to increased mortality in hemodialysis (HD) patients. YKL-40 is a novel marker of inflammation, tissue remodeling, and highly expressed in macrophages inside vascular lesions. Elevated levels of YKL-40 have been reported for HD patients but how it integrates into the proinflammatory me...

journal_title：Kidney international

authors： Lorenz G,Schmalenberg M,Kemmner S,Haller B,Steubl D,Pham D,Schreiegg A,Bachmann Q,Schmidt A,Haderer S,Huber M,Angermann S,Günthner R,Braunisch M,Hauser C,Reichelt AL,Matschkal J,Suttmann Y,Moog P,Stock K,Küchle C

更新日期：2018-01-01 00:00:00

abstract：:Polycystic kidney disease progresses more rapidly in men than in women. To investigate the basis for this sexual dimorphism, we exposed Madin-Darby canine kidney (MDCK) cells grown on collagen-coated cell culture inserts to control media, or to estradiol or testosterone (1 nM-1 microM). Compared to control and estradi...

journal_title：Kidney international

authors： Sandhu S,Silbiger SR,Lei J,Neugarten J

更新日期：1997-05-01 00:00:00

abstract：:Organomercurial diuretics stimulate renin secretion although the underlying cellular mechanisms remain undefined. Since organomercurials are also known to react with sulfhydryl groups, the present studies determined the effects of sulfhydryl reagents on renin secretion. The effects of the non-diuretic mercurial agent,...

journal_title：Kidney international

authors： Lee DY,Cho KW,Lee JS,Honeyman TW,Park CS

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:We have recently demonstrated an increase in apoptosis in Han:SPRD rat kidneys with autosomal-dominant polycystic kidney disease (ADPKD). Caspase-3 and caspase-7 are major mediators of apoptosis. There are two pathways of caspase-3 and caspase-7-mediated apoptosis: (1) the "extrinsic" pathway involving the d...

journal_title：Kidney international

authors： Tao Y,Kim J,Stanley M,He Z,Faubel S,Schrier RW,Edelstein CL

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Normal human podocytes are terminally differentiated and quiescent cells. It is not known why podocytes fail to proliferate in response to most forms of injury. Proliferation is regulated by cell cycle proteins and their inhibitors. The Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors (p21, p27, p5...

journal_title：Kidney international

authors： Shankland SJ,Eitner F,Hudkins KL,Goodpaster T,D'Agati V,Alpers CE

更新日期：2000-08-01 00:00:00

abstract：:The beta-amino acid transport capabilities of rat renal epithelium were assessed using brushborder membrane vesicles (BBMV). Taurine, a metabolically inert sulfur-containing amino acid, was studied with emphasis on the renal adaptation to dietary sulfur amino acid alteration. Three isoproteinic diets were given to Spr...

journal_title：Kidney international

authors： Chesney RW,Gusowski N,Friedman AL

更新日期：1983-11-01 00:00:00

abstract：:To determine whether Cyclosporine A (CsA) alters the intrarenal expression of the renin and type 1 angiotensin II receptor genes, male adult Sprague-Dawley rats were given 25 mg/kg/day CsA s.c. for three weeks (CsA, N = 20) and were compared to pair-fed vehicle treated rats (Con, N = 20). The intrarenal distribution o...

journal_title：Kidney international

authors： Tufro-McReddie A,Gomez RA,Norling LL,Omar AA,Moore LC,Kaskel FJ

更新日期：1993-03-01 00:00:00

abstract：:Tissandié and colleagues report in this issue on their studies of IgA1 glycosylation and biological activities of IgA1-containing circulating immune complexes in patients with alcoholic cirrhosis who developed secondary renal disease with IgA deposits, secondary IgA nephropathy. Their seminal findings demonstrate abno...

journal_title：Kidney international

authors： Novak J,Julian BA

更新日期：2011-12-01 00:00:00

abstract：:Quartan malarial infection causes an immune complex nephritis in some individuals, which, once established, is sustained by mechanisms not yet fully explained, but which probably involve autoimmune processes. The presenting clinical and biochemical findings of the quartan malarial nephrotic syndrome are similar to tho...

journal_title：Kidney international

authors： Hendrickse RG,Adeniyi A

更新日期：1979-07-01 00:00:00

abstract：:Unilateral progressive Masugi nephritis was produced in rabbits and studied by microangiography as well as light and immunofluorescence microscopy. The following five groups were studied: Group 1. Heparin was started simultaneously with nephrotoxic serum (NTS) and was given for one week. The animals were then sacrific...

journal_title：Kidney international

authors： Nakamoto Y,Dohi K,Fujike H,Yuri T,Shinoda A,Takeuchi J

更新日期：1978-04-01 00:00:00

abstract：:Daily calcitriol therapy has been reported to improve linear growth in children with renal bone disease, and 1,25-dihydroxyvitamin D is a key regultor of chondrocyte proliferation and differentiation. Whereas large intermittent doses of calcitriol can lower serum parathyroid hormone (PTH) levels and reverse the skelet...

journal_title：Kidney international

authors： Kuizon BD,Goodman WG,Jüppner H,Boechat I,Nelson P,Gales B,Salusky IB

更新日期：1998-01-01 00:00:00

abstract：:It is unknown whether mild chronic kidney disease (CKD) is associated with adverse cardiovascular (CV) prognosis after accounting for coronary artery disease (CAD). Here we evaluated the interplay between CKD and CAD in predicting CV death or myocardial infarction (MI) and all-cause death. We included 1541 consecutive...

journal_title：Kidney international

authors： Bittencourt MS,Hulten EA,Ghoshhajra B,Abbara S,Murthy VL,Divakaran S,Nasir K,Gowdak LH,Riella LV,Chiumiento M,Hoffmann U,Di Carli MF,Blankstein R

更新日期：2015-07-01 00:00:00

abstract：:We have recently presented evidence that endogenous nitric oxide (NO) and prostaglandins (PGs) modulate angiotensin II (Ang II) action in microperfused afferent arterioles (Af-Arts). Because flow may be a physiological stimulus of endothelial release of NO and PGs, we tested the hypothesis that flow through the lumen ...

journal_title：Kidney international

authors： Juncos LA,Ren Y,Arima S,Garvin J,Carretero OA,Ito S

更新日期：1996-02-01 00:00:00

abstract：:Previous studies from our laboratory have characterized the peripheral metabolism of parathyroid hormone (PTH) in the dog using radioimmunoassay techniques following injection or infusion of biologically active, bovine PTH preparations. Other investigators have used biologically-inactive labelled PTH and interpreted t...

journal_title：Kidney international

authors： Martin KJ,Finch JL,Hruska K,Slatopolsky E

更新日期：1987-04-01 00:00:00

abstract：:The formation of the non-sulphated glycosaminoglycan hyaluronan by cells of the renal glomerulus in diabetes may contribute to altered matrix composition. We describe an increased production of hyaluronan from mesangial cell-enriched glomerular cores from diabetic animals, and further show that increased hyaluronan pr...

journal_title：Kidney international

authors： Dunlop ME,Clark S,Mahadevan P,Muggli E,Larkins RG

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:In X-linked Alport syndrome, mutations in the COL4A5 gene encoding the alpha 5 chain of type IV collagen result in progressive renal failure. This nephropathy appears to relate to the arrest of a switch from an alpha 1/alpha 2 to an alpha 3/alpha 4/alpha 5 network of type IV collagen in the developing glomer...

journal_title：Kidney international

authors： Harvey SJ,Zheng K,Sado Y,Naito I,Ninomiya Y,Jacobs RM,Hudson BG,Thorner PS

更新日期：1998-12-01 00:00:00

abstract：:Accumulation of extracellular matrix within the mesangium is an important event in the development of glomerular disease. In this report we have used indirect immunofluorescence to positively identify a number of constituents of the mesangial matrix synthesized by rat mesangial cells (RMC) in vitro including laminin, ...

journal_title：Kidney international

authors： Thomas GJ,Shewring L,McCarthy KJ,Couchman JR,Mason RM,Davies M

更新日期：1995-10-01 00:00:00

abstract：:Polyomavirus-associated nephropathy (PVAN) is a significant complication after kidney transplantation, often leading to premature graft loss. In order to identify antiviral responses of the renal tubular epithelium, we studied activation of the viral DNA and the double-stranded RNA (dsRNA) sensors Toll-like receptor 3...

journal_title：Kidney international

authors： Ribeiro A,Wörnle M,Motamedi N,Anders HJ,Gröne EF,Nitschko H,Kurktschiev P,Debiec H,Kretzler M,Cohen CD,Gröne HJ,Schlöndorff D,Schmid H

更新日期：2012-01-01 00:00:00

abstract：:The role of peritoneal dialysis (PD) in renal replacement therapy (RRT) remains unclear. There are no controlled trials to provide hard evidence of its efficacy. Comparative studies with haemodialysis from different centres and countries have given conflicting results even when allowing for case mix. Data from the Uni...

journal_title：Kidney international

authors： Coles GA,Williams JD

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Microarray technology is a powerful tool that can probe the molecular pathogenesis of renal injury. In this present study microarray analysis was used to monitor serial changes in the renal transcriptome of a rat model of mesangial proliferative glomerulonephritis. Administration of anti-Thy1 antibody result...

journal_title：Kidney international

authors： Sadlier DM,Ouyang X,McMahon B,Mu W,Ohashi R,Rodgers K,Murray D,Nakagawa T,Godson C,Doran P,Brady HR,Johnson RJ

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Only few noninvasive methods have the potential to quantitate renal blood flow (RBF) in humans. Positron emission tomography (PET) is a clinical imaging method that can be used to measure the tissue blood flow noninvasively. The purpose of this study was to validate PET measurement of RBF using 15O-labeled w...

journal_title：Kidney international

authors： Juillard L,Janier MF,Fouque D,Lionnet M,Le Bars D,Cinotti L,Barthez P,Gharib C,Laville M

更新日期：2000-06-01 00:00:00

abstract：:We have described a simple technique for the measurement of picomoles or nanomoles of ammonium. Samples can be easily processed on the day of an experiment. analysis of 14C-glutamate can be done at a later date by an accurate sensitive and reliable method. We can readily process 50 samples per day. The sensitivity can...

journal_title：Kidney international

authors： Cheema-Dhadli S,Hamat R,Sonnenberg H,Halperin M

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension. Hypertension is a strong independent risk factor for progression in IgA nephropathy...

journal_title：Kidney international

authors： Thibaudin L,Berthoux P,Thibaudin D,Mariat C,Berthoux F

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Human mesothelial cells (HMCs) have an important role in maintaining an adequately functioning fibrinolytic system in the peritoneal cavity by secreting the fibrinolytic enzymes tissue-type and urokinase-type plasminogen activator (t-PA and u-PA), as well as a specific PA inhibitor, PA inhibitor type 1 (PAI-...

journal_title：Kidney international

authors： Sitter T,Toet K,Quax P,Kooistra T

更新日期：1999-01-01 00:00:00