Abstract：
:The aim of this paper is to apply machine learning as a method to refine a manually constructed CPN for the assessment of the severity of the systemic inflammatory response syndrome (SIRS).The goal of tuning the CPN is to create a scoring system that uses only objective data, compares favourably with other severity-scoring systems and differentiates between sepsis and non-infectious SIRS. The resulting model, the Learned-Age (LA) -Sepsis CPN has good discriminatory ability for the prediction of 30-day mortality with an area under the ROC curve of 0.79. This result compares well to existing scoring systems. The LA-Sepsis CPN also has a modest ability to discriminate between sepsis and non-infectious SIRS.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Ward L,Paul M,Andreassen Sdoi
10.1016/j.mbs.2016.11.004subject
Has Abstractpub_date
2017-02-01 00:00:00pages
12-20eissn
0025-5564issn
1879-3134pii
S0025-5564(16)30291-7journal_volume
284pub_type
杂志文章abstract：:A mathematical multi-cell model for the in vitro kinetics of the anti-cancer agent topotecan (TPT) following administration into a culture medium containing a population of human breast cancer cells (MCF-7 cell line) is described. This non-linear compartmental model is an extension of an earlier single-cell type model...
journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(94)00061-4
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(91)90083-u
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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journal_title：Mathematical biosciences
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