Abstract：
:Invariants are functions of the probabilities of state configurations among lineages, with expected values equal to zero under certain phylogenies. For two-state sequences, the existence of certain quadratic invariants requires a symmetric substitution model. For sequences with more than two states, the necessary condition for the existence of certain quadratic invariants in terms of independent events is much stronger than symmetry. For DNA sequences, only three parameters are allowed in the substitution model, which includes Kimura's two-parameter model as a special case.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Fu YX,Li WHdoi
10.1016/0025-5564(91)90083-usubject
Has Abstractpub_date
1991-07-01 00:00:00pages
229-38issue
2eissn
0025-5564issn
1879-3134pii
0025-5564(91)90083-Ujournal_volume
105pub_type
杂志文章abstract：:Threshold parameters of epidemic models play a central role in the assessment of proposed control strategies for infectious diseases. They have been determined for numerous standard epidemic models. This paper points out, with several examples, that threshold parameters depend on the social setting of the community an...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(94)00061-4
更新日期：1995-10-01 00:00:00
abstract：:An optimal parameter selection model of cancer chemotherapy is presented which describes the treatment of a tumor over a fixed period of time by the repeated administration of a single drug. The drug is delivered at evenly spaced intervals over the treatment period at doses to be selected by the model. The model const...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(90)90005-j
更新日期：1990-05-01 00:00:00
abstract：:Some viruses encode proteins that promote cell proliferation while others, such as the human immunodeficiency virus (HIV), encode proteins that prevent cell division. It has been hypothesized that the selective advantage determining which strategy evolves depends on the ability of the virus to induce a cellular enviro...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(00)00020-1
更新日期：2000-07-01 00:00:00
abstract：:A mathematical model for multispecies biofilm evolution based on continuum approach and mass conservation principles is presented. The model can describe biofilm growth dynamics including spatial distribution of microbial species, substrate concentrations, attachment, and detachment, and, in particular, is able to pre...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2014.10.009
更新日期：2015-01-01 00:00:00
abstract：:We investigate a mathematical model of tumor-immune interactions with chemotherapy, and strategies for optimally administering treatment. In this paper we analyze the dynamics of this model, characterize the optimal controls related to drug therapy, and discuss numerical results of the optimal strategies. The form of ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.05.003
更新日期：2007-09-01 00:00:00
abstract：:Employing theoretical models, we show that the sterile insect release method (SIRM) can give rise to traveling waves of fertile insects. The velocity of these waves depends critically upon the density of sterile insects (and thus upon the rate at which sterile individuals are being released into the environment). When...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(93)90067-k
更新日期：1993-08-01 00:00:00
abstract：:Lateral inhibition, a juxtacrine signalling mechanism by which a cell adopting a particular fate inhibits neighbouring cells from doing likewise, has been shown to be a robust mechanism for the formation of fine-grained spatial patterns (in which adjacent cells in developing tissues diverge to achieve contrasting stat...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2011.03.003
更新日期：2011-06-01 00:00:00
abstract：:According to metapopulation theory, the capacity of a habitat patch network to support the persistence of a species is measured by the metapopulation capacity of the patch network. Mathematically, metapopulation capacity is given by the leading eigenvalue lambda(M) of an appropriately constructed non-negative n x n ma...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(02)00150-5
更新日期：2003-02-01 00:00:00
abstract：:The aim of this paper is to develop a minimal model describing events leading to the onset of Parkinson's disease (PD). The model accounts for α-synuclein (α-syn) production in the soma, transport toward the synapse, misfolding, and aggregation. The production and aggregation of polymeric α-syn is simulated using a mi...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2016.05.002
更新日期：2016-08-01 00:00:00
abstract：:The goal of this article is to formulate and analyze the simplest logistic pair-formation model and to contrast its dynamics to that of the corresponding Malthusian pair-formation model, that is, a generalization of the Kendall-Keyfitz model. The Malthusian pair-formation model supports a unique nontrivial stable expo...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(94)00077-d
更新日期：1995-07-01 00:00:00
abstract：:The reaction-diffusion equation is one of the possible ways for modeling animal movement, where the reactive part stands for the population growth and the diffusive part for random dispersal of the population. However, a reaction-diffusion model may not represent all aspects of the spatial dynamics, because of the exi...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2020.108346
更新日期：2020-06-01 00:00:00
abstract：:Statistical consistency in phylogenetics has traditionally referred to the accuracy of estimating phylogenetic parameters for a fixed number of species as we increase the number of characters. However, it is also useful to consider a dual type of statistical consistency where we increase the number of species, rather ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2010.07.002
更新日期：2010-10-01 00:00:00
abstract：:It has been shown in the literature that myocytes isolated from the ventricular walls at various intramural depths have different action potential durations (APDs). When these myocytes are embedded in the ventricular wall, their inhomogeneous properties affect the sequence of repolarization and the actual distribution...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2006.06.002
更新日期：2006-11-01 00:00:00
abstract：:An optimal input of nutrients into the metabolic process of the individual subject so as to effect desired therapeutic results is particularly important for the critically ill. A patient-related, individualized nutrients optimization procedure is proposed here. The procedure is applicable to any time-invariant and det...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/0025-5564(89)90004-7
更新日期：1989-12-01 00:00:00
abstract：:The combination therapy of antiviral peg-interferon and ribavirin has evolved as one of the better treatments for hepatitis C. In spite of its success in controlling hepatitis C infection, it has also been associated with treatment-related adverse side effects. The most common and life threatening among them is hemoly...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2010.02.005
更新日期：2010-06-01 00:00:00
abstract：:Many important results in stochastic epidemic modelling are based on the Reed-Frost model or on other similar models that are characterised by unrealistic temporal dynamics. Nevertheless, they can be extended to many other more realistic models thanks to an argument first provided by Ludwig [Final size distributions f...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2008.08.009
更新日期：2008-11-01 00:00:00
abstract：:Two optimization problems are considered: Harvesting from a structured population with maximal gain subject to the condition of non-extinction, and vaccinating a population with prescribed reduction of the reproduction number of the disease at minimal costs. It is shown that these problems have a similar structure and...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2005.09.001
更新日期：2007-04-01 00:00:00
abstract：:In estimating mutation rates using the Luria-Delbrück experimental protocol, it is often assumed that all mutant cells survive the plating procedure to form visible mutant colonies. This assumption of perfect plating efficiency may not hold in certain circumstances, but none of the existing estimation methods that adj...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2008.09.002
更新日期：2008-12-01 00:00:00
abstract：:Many mathematical models in biology and physiology are represented by systems of nonlinear differential equations. In recent years these models have become increasingly complex in order to explain the enormous volume of data now available. A key role of modellers is to determine which components of the model have the ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2013.12.011
更新日期：2014-02-01 00:00:00
abstract：:Isotope labeling systems (ILSs) are sets of balance equations that quantitatively describe the distribution of isotopic tracers in metabolic networks. The solution of ILSs, i.e., the calculation of isotopic labeling distributions (mostly in steady state) is the fundamental computational step of (13)C metabolic flux an...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2013.02.012
更新日期：2013-07-01 00:00:00
abstract：:The statistical characterization of the spatial structure of large animal groups has been very limited so far, mainly due to a lack of empirical data, especially in three dimensions (3D). Here we focus on the case of large flocks of starlings (Sturnus vulgaris) in the field. We reconstruct the 3D positions of individu...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2008.05.006
更新日期：2008-07-01 00:00:00
abstract：:The introduction of endosymbiont Wolbachia into laboratory-reared mosquito populations, which are then released to mix with natural populations to prevent the mosquito vectors from reproducing and thus break the transmission cycle of dengue disease, is an innovative new technology. Field trials of Wolbachia-carrying m...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2018.03.003
更新日期：2018-05-01 00:00:00
abstract：:A variety of growth curves have been developed to model both unpredated, intraspecific population dynamics and more general biological growth. Most predictive models are shown to be based on variations of the classical Verhulst logistic growth equation. We review and compare several such models and analyse properties ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(02)00096-2
更新日期：2002-07-01 00:00:00
abstract：:Amyloid beta (Aβ) peptides, and in particular Aβ42, are found in senile plaques associated with Alzheimer's disease. A compartmental model of Aβ production, exchange and irreversible loss was recently developed to explain the kinetics of isotope-labeling of Aβ peptides collected in cerebrospinal fluid (CSF) following ...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2014.11.004
更新日期：2015-03-01 00:00:00
abstract：:The goal of this study is to uncover some unobservable aspects of the individual-patient natural history of metastatic renal cell carcinoma (RCC) through mathematical modeling. We analyzed four clear cell RCC patients who at the time of primary tumor resection already had pulmonary metastases. Our description of the n...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2019.01.008
更新日期：2019-03-01 00:00:00
abstract：:Multi-patch models - also known as metapopulation models - provide a simple framework within which the role of spatial processes in disease transmission can be examined. An n-patch model which distinguishes between k different classes of individuals is considered. The linear stability of spatially homogeneous solution...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2003.09.003
更新日期：2004-03-01 00:00:00
abstract：:Most endocrine cells secrete hormones as a result of Ca2+-regulated exocytosis, i.e., fusion of the membranes of hormone-containing secretory granules with the cell membrane, which allows the hormone molecules to escape to the extracellular space. As in neurons, electrical activity and cell depolarization open voltage...
journal_title：Mathematical biosciences
pub_type： 杂志文章,评审
doi：10.1016/j.mbs.2016.11.010
更新日期：2017-01-01 00:00:00
abstract：:This paper investigates the effects of vaccination on the dynamics of infectious disease, which is spreading in a population concurrently with awareness. The model considers contributions to the overall awareness from a global information campaign, direct contacts between unaware and aware individuals, and reported ca...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2017.09.007
更新日期：2017-12-01 00:00:00
abstract：:In microarray data analysis, traditional methods that focus on single genes are increasingly replaced by methods that analyse functional units corresponding to biochemical pathways, as these are considered to offer more insight into gene expression and disease associations. However, the development of robust pipelines...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/j.mbs.2014.09.005
更新日期：2015-02-01 00:00:00
abstract：:For cDNA array methods that depend on imaging of a radiolabel, we show that bleedover of one spot onto another, due to the gap between the array and the imaging media, can be a major problem. The images can be sharpened, however, using a blind convolution method based on the EM algorithm. The sharpened images look lik...
journal_title：Mathematical biosciences
pub_type： 杂志文章
doi：10.1016/s0025-5564(01)00101-8
更新日期：2002-03-01 00:00:00
