Abstract：
:Isotope labeling systems (ILSs) are sets of balance equations that quantitatively describe the distribution of isotopic tracers in metabolic networks. The solution of ILSs, i.e., the calculation of isotopic labeling distributions (mostly in steady state) is the fundamental computational step of (13)C metabolic flux analysis (MFA). Aiming at a deeper analytical understanding of ILSs a new approach for solving ILSs is developed. It is based on the straightforward idea of tracing labeled molecules through the metabolic network. The new approach allows to calculate the label distribution in isotopic tracer experiments in an analytical way that directly reflects the underlying network structure. The theory of path tracing is formally developed by introducing regular expressions for representing all possible paths through the labeling network. These expressions are generated by classical path tracing algorithms, e.g. by the Kleene algorithm. As a central theoretical result, a framework for proving the correctness of such path tracing algorithms in their application to ILSs is developed. Finally, by mapping path expressions to algebraic expressions, the solution of an ILS is computed. As an offspring of the developed theory, the relation between path tracing and former approaches for ILS solution is worked out and several consequences for the numerical solution and analysis of ILSs and--more general--compartmental systems used in pharmaco-kinetic modeling will be sketched.
journal_name
Math Bioscijournal_title
Mathematical biosciencesauthors
Wiechert W,Nöh K,Weitzel Mdoi
10.1016/j.mbs.2013.02.012subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1-12issue
1eissn
0025-5564issn
1879-3134pii
S0025-5564(13)00071-0journal_volume
244pub_type
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