Inflammatory markers in saliva as indicators of gingival inflammation in cerebral palsy children with and without cervical motor control.

Abstract:

AIM:To evaluate the relation among gingival inflammation, salivary osmolality, levels of IL-1β, IL-6, IL-8, TNF-α, and s-IgA concentrations in children with spastic CP with or without cervical motor control in a cross-sectional study. DESIGN:Unstimulated whole saliva and the gingival index were collected in 37 and 34 CP children with and without cervical motor control, respectively. The data were dichotomized as follows: (=0) absence of gingival inflammation and (≥0.1) presence of gingival inflammation. RESULTS:The group without cervical control presented statistically higher mean values of salivary osmolality, s-IgA, and cytokines. In addition, statistically positive correlation between the gingival index and salivary cytokines was observed in the group with cervical control. Salivary osmolality, salivary cytokines, and s-IgA from both groups presented a significant positive correlation. Significant differences (P = 0.00336) in the values of salivary osmolality were observed between the CP individuals with (93.9 ± 32.7) and without gingival inflammation (74.4 ± 16.6). ROC analysis was performed, and values of salivary osmolality >80 indicated a sensitivity of 0.54 and a specificity of 0.79. CONCLUSIONS:Children without cervical motor control presented a more pronounced oral inflammatory status that was characterized by higher levels of cytokines.

journal_name

Int J Paediatr Dent

authors

Santos MTBR,Diniz MB,Guaré RO,Ferreira MCD,Gutierrez GM,Gorjão R

doi

10.1111/ipd.12270

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

364-371

issue

5

eissn

0960-7439

issn

1365-263X

journal_volume

27

pub_type

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