Capnocytophaga in the dental plaque of immunocompromised children with cancer.

Abstract:

OBJECTIVES:(i) To compare the prevalence and levels of Capnocytophaga, a known systemic pathogen in immunocompromised patients, in the dental plaque of healthy children and children with cancer, and (ii) to determine the susceptibility of strains isolated from cancer patients to a range of antibiotics. PATIENTS AND METHODS:Thirty-one children with cancer undergoing a first course of immunosuppressive chemotherapy and 30 healthy control children were included in the study. Samples were collected on days 0, 7, 14, and 21 of the cure (and equivalent dates in controls). Susceptibility to antibiotics was tested using an agar dilution method and galleries with predefined concentrations of selected antibiotics. RESULTS:There was a significant drop in the total anaerobic cultivable flora on day 14 and in the prevalence of Capnocytophaga on days 14 and 21 in the children with cancer. The proportion of Capnocytophaga in the anaerobic flora, however, was high in certain cancer patients. Beta-lactam/beta-lactamase inhibitor combinations, imipenem, clindamycin, and tetracycline were the most effective against Capnocytophaga. CONCLUSION:This study showed that Capnocytophaga decreased in prevalence and proportion in the dental plaque of cancer patients during chemotherapy but became predominant in some cases. It is recommended that imipenem or beta-lactam/beta-lactamase inhibitor combinations be used to treat Capnocytophaga bacteraemia.

journal_name

Int J Paediatr Dent

authors

Sixou JL,Aubry-Leuliette A,De Medeiros-Battista O,Lejeune S,Jolivet-Gougeon A,Solhi-Pinsard H,Gandemer V,Barbosa-Rogier M,Bonnaure-Mallet M

doi

10.1111/j.1365-263X.2006.00697.x

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

75-80

issue

2

eissn

0960-7439

issn

1365-263X

pii

IPD697

journal_volume

16

pub_type

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