Abstract:
:Chagas disease is one of the most important vector-borne zoonotic diseases in Latin America. Control strategies could be improved if transmissibility patterns of its aetiologic agent, Trypanosoma cruzi, were better understood. To understand transmissibility patterns of Chagas disease in Mexico, we inferred potential vectors and hosts of T. cruzi from geographic distributions of nine species of Triatominae and 396 wild mammal species, respectively. The most probable vectors and hosts of T. cruzi were represented in a Complex Inference Network, from which we formulated a predictive model and several associated hypotheses about the ecological epidemiology of Chagas disease. We compiled a list of confirmed mammal hosts to test our hypotheses. Our tests allowed us to predict the most important potential hosts of T. cruzi and to validate the model showing that the confirmed hosts were those predicted to be the most important hosts. We were also able to predict differences in the transmissibility of T. cruzi among triatomine species from spatial data. We hope our findings help drive efforts for future experimental studies.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Rengifo-Correa L,Stephens CR,Morrone JJ,Téllez-Rendón JL,González-Salazar Cdoi
10.1017/S0031182016002468subject
Has Abstractpub_date
2017-05-01 00:00:00pages
760-772issue
6eissn
0031-1820issn
1469-8161pii
S0031182016002468journal_volume
144pub_type
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