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Galectin-3 is associated with coronary plaque burden and obstructive sleep apnoea syndrome severity.

Abstract：

BACKGROUND:Obstructive sleep apnoea syndrome (OSAS) is reported to be associated with hypertension, coronary artery disease, atrial fibrillation, and heart failure. Galectin-3 plays an important role in the regulation of inflammation, development of cardiac fibrosis, and remodelling. A significant relationship between galectin-3 and the total number of coronary plaques and the macrocalcified plaque structures of patients with type 2 diabetes mellitus has been reported. AIM:The aim of this study was to investigate the association between galectin-3 level and coronary plaque burden as well as OSAS severity in patients with OSAS. METHODS:A total of 87 consecutive patients with a diagnosis of OSAS and 21 age- and gender-matched control subjects were recruited for the present study. The patients with OSAS were also categorised according to their apnoea hypopnoea index (AHI) as follows: mild (AHI = 5-15), moderate (AHI = 15-30), and severe (AHI > 30). All study subjects underwent coronary computed tomography angiography to detect coronary atherosclerosis. Also, all participants of serum galectin-3 concentrations were measured. RESULTS:Mean galectin-3 level was significantly higher in patients with OSAS compared to control subjects (p < 0.001) and in the severe OSAS group, compared to the moderate and mild OSAS groups (p < 0.001). Correlation analysis indicated significant positive relationships between galectin-3 concentrations and the total number of coronary plaques (p < 0.001), high-sensitivity C-reactive protein (p = 0.001), and severity of OSAS (p < 0.001). In multivariate analysis, galectin-3 (p = 0.01) and age (p = 0.025) were significant independent predictors of coronary atherosclerosis, after adjusting for other risk factors. Also, it has been found that galectin-3 concentration is a predictor of OSAS severity (p = 0.001). CONCLUSIONS:Galectin-3 is associated with coronary atherosclerosis and OSAS severity in OSAS patients.

journal_name

Kardiol Pol

journal_title

Kardiologia polska

authors

Pusuroglu H,Somuncu U,Bolat I,Akgul O,Ornek V,Yıldırım HA,Akkaya E,Karakurt H,Yıldırım A,Savaş AU

doi

10.5603/KP.a2016.0185

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

351-359

issue

eissn

0022-9032

issn

1897-4279

pii

VM/OJS/KP/10784

journal_volume

pub_type

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Galectin-3 is associated with coronary plaque burden and obstructive sleep apnoea syndrome severity.