Regulation of LH subunit and prolactin mRNA by gonadal hormones in mice.

abstract：:The contribution of hypothalamic appetite-regulating peptides to further hyperphagia accompanying the course of lactation in rats was investigated by using PCR array and real-time PCR. Furthermore, changes in the mRNA expression for appetite-regulating peptides in the hypothalamic arcuate nucleus (ARC) were analyzed a...

journal_title：Journal of molecular endocrinology

authors： Suzuki Y,Nakahara K,Maruyama K,Okame R,Ensho T,Inoue Y,Murakami N

更新日期：2014-01-30 00:00:00

abstract：:In vitro studies have indicated that the maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DP, DHP), probably through nuclear progestin receptor (Pgr), might be involved in the proliferation of spermatogonial cells and the initiation of meiosis in several fish species. However, further in vivo evi...

journal_title：Journal of molecular endocrinology

authors： Liu G,Luo F,Song Q,Wu L,Qiu Y,Shi H,Wang D,Zhou L

更新日期：2014-08-01 00:00:00

abstract：:This study examined fetal steroidogenic enzyme expression and function during pregnancy in the pig. Northern and Western analyses were performed to detect the cytochrome P450 enzyme 17 alpha-hydroxylase/17-20 lyase (P450c17) and that for cholesterol side-chain cleavage (P450scc), as well as 3 beta-hydroxysteroid dehyd...

journal_title：Journal of molecular endocrinology

authors： Conley AJ,Rainey WE,Mason JI

更新日期：1994-04-01 00:00:00

abstract：:Tumour necrosis factor superfamily member 11 (TNFSF11) gene, that codes for receptor activator of nuclear factor-kappaB ligand, is one of the candidate genes for the genetic susceptibility to osteoporosis. As variations in the TNFSF11 gene promoter could alter its expression, the aim of the study was to evaluate the f...

journal_title：Journal of molecular endocrinology

authors： Mencej S,Albagha OM,Prezelj J,Kocjan T,Marc J

更新日期：2008-06-01 00:00:00

abstract：:17β-Estradiol (E(2)) plays important roles in functions of many tissues. E(2) effects are mediated by estrogen receptor (ER) α and β. ERs regulate transcriptions through estrogen-responsive element (ERE)-dependent and ERE-independent modes of action. ER binding to ERE constitutes the basis of the ERE-dependent pathway...

journal_title：Journal of molecular endocrinology

authors： Muyan M,Callahan LM,Huang Y,Lee AJ

更新日期：2012-10-30 00:00:00

abstract：:It has recently been shown that 20 kDa human growth hormone (hGH) forms the 1:2 hGH:hGH receptor (hGHR) complex and expresses full agonistic activity, although it hardly forms the 1:1 GH:GHR complex as compared with 22 kDa hGH. To clarify this mechanism, we analyzed the mode of receptor dimerization of 20 kDa hGH usin...

journal_title：Journal of molecular endocrinology

authors： Uchida H,Banba S,Wada M,Matsumoto K,Ikeda M,Naito N,Tanaka E,Honjo M

更新日期：1999-12-01 00:00:00

abstract：:In vertebrates, sex is determined essentially by two means, genetic factors located on sex chromosomes and epigenetic factors such as temperature experienced by the individual during development. Steroids, especially estrogens, are clearly involved in gonadal differentiation in non-mammalian vertebrates. In this regar...

journal_title：Journal of molecular endocrinology

authors： Kuntz S,Chesnel A,Flament S,Chardard D

更新日期：2004-12-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP1) is an intestinal incretin that regulates glucose homeostasis through stimulation of insulin secretion from pancreatic β-cells and inhibits appetite by acting on the brain. Thus, it is a promising therapeutic agent for the treatment of type 2 diabetes mellitus and obesity. Studies using s...

journal_title：Journal of molecular endocrinology

authors： Hwang JI,Yun S,Moon MJ,Park CR,Seong JY

更新日期：2014-06-01 00:00:00

abstract：:In this study we examine changes in the cellular properties of FRTL-5 cells as a function of passage number, with particular emphasis on gap junction expression, karyotype, morphology, growth rate and thyroxine (T(4)) release. Early passage FRTL-5 follicular cells transfer dye through gap junctions from injected cell(...

journal_title：Journal of molecular endocrinology

authors： Green LM,Murray DK,Tran DT,Nelson GA,Shah MM,Luben RA

更新日期：2001-10-01 00:00:00

abstract：:Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, such as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1) and connexin-43. Decidual cells are also in...

journal_title：Journal of molecular endocrinology

authors： Duval F,Dos Santos E,Moindjie H,Serazin V,Swierkowski-Blanchard N,Vialard F,Dieudonné MN

更新日期：2017-10-01 00:00:00

abstract：:Parathyroid hormone (PTH), a powerful bone-resorbing agent, is capable of stimulating interstitial collagenase (MMP-13) mRNA production in osteoblastic cells. In this study, a PEA3 consensus binding sequence (-80; AGGAAGT) in addition to a 'TRE-like' sequence (-89; CGACTCA) in the 5' upstream regulatory region of the ...

journal_title：Journal of molecular endocrinology

authors： Quinn CO,Rajakumar RA,Agapova OA

更新日期：2000-08-01 00:00:00

abstract：:Several hormone agonists exert their physiological actions by triggering an inositol phospholipid-Ca2+ signalling cascade and cytosolic alkalinization. Although calcium ionophores have been used extensively to probe the role of Ca2+ in the regulation of steroidogenesis in granulosa cells, the precise relationship betw...

journal_title：Journal of molecular endocrinology

authors： Asem EK,Li M,Tsang BK

更新日期：1992-08-01 00:00:00

abstract：:Hypogonadal (hpg) mutant mice, with a congenital deficiency of hypothalamic gonadotrophin-releasing hormone (GnRH), and testicular feminized (tfm) mice, which lack a functional androgen receptor, were used to study the effects of the potent GnRH agonist 'Zoladex' (ICI 118630; D-Ser (Bu(t))6, Azgly10-GnRH) on pituitary...

journal_title：Journal of molecular endocrinology

authors： Scott IS,Bennett MK,Porter-Goff AE,Harrison CJ,Cox BS,Grocock CA,O'Shaughnessy PJ,Clayton RN,Craven R,Furr BJ

更新日期：1992-06-01 00:00:00

abstract：:Unliganded thyroid hormone receptors (apoTRs) repress transcription of hormone-activated genes by recruiting corepressors to the promoters. In contrast, on promoters containing so-called negative thyroid hormone response elements (nTREs), apoTRs activate transcription. A number of different molecular mechanisms have b...

journal_title：Journal of molecular endocrinology

authors： Nygård M,Becker N,Demeneix B,Pettersson K,Bondesson M

更新日期：2006-06-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) analogues were produced with the aim of identifying IGF-I residues that contribute to the specificity of binding to the type 1 IGF receptor as opposed to the insulin receptor. Receptor binding properties of a series of A- and B-domain analogues were compared using rat L6 myoblasts,...

journal_title：Journal of molecular endocrinology

authors： Shooter GK,Magee B,Soos MA,Francis GL,Siddle K,Wallace JC

更新日期：1996-12-01 00:00:00

abstract：:Somatostatins (SSs) play important roles in the growth, development and metabolism of vertebrates. In this study, cDNAs for two unique somatostatin receptor variants were cloned and sequenced from rainbow trout. The two cDNAs, one consisting of 1755 bp and the other of 1743 bp, share 63.6% identity in nucleotide seque...

journal_title：Journal of molecular endocrinology

authors： Slagter BJ,Sheridan MA

更新日期：2004-02-01 00:00:00

abstract：:Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabe...

journal_title：Journal of molecular endocrinology

authors： Xu M,Chen X,Yan L,Cheng H,Chen W

更新日期：2008-05-01 00:00:00

abstract：:Binding of 125I-labelled arginine vasotocin (AVT) was studied in isolated intact gill cells obtained from eels (Anguilla anguilla) adapted to fresh water (FW) or to sea water (SW). Experiments carried out at 20 degrees C showed maximum and stable binding beyond 10 min of incubation. Specific binding, determined by usi...

journal_title：Journal of molecular endocrinology

authors： Guibbolini ME,Henderson IW,Mosley W,Lahlou B

更新日期：1988-09-01 00:00:00

abstract：:Translocation of protein kinase C (PKC) from the cytosol to the plasma membranes is believed to reflect activation of the enzyme. We have studied translocation of PKC in lactotroph-enriched anterior pituitary cell cultures by measuring the incorporation of gamma-32P from [gamma-32P]ATP into a synthetic peptide substra...

journal_title：Journal of molecular endocrinology

authors： Mau SE,Saermark T,Vilhardt H

更新日期：1994-06-01 00:00:00

abstract：:The p160 coactivators, steroid receptor coactivator-1 (SRC-1), transcriptional intermediary factor-2 (TIF2) and receptor-associated coactivator-3 (RAC3), as well as the coactivator/integrator CBP, mediate estrogen receptor-alpha (ERalpha)-dependent gene expression. Although these coactivators are widely expressed, ERa...

journal_title：Journal of molecular endocrinology

authors： Jaber BM,Mukopadhyay R,Smith CL

更新日期：2004-02-01 00:00:00

abstract：:An isolated in-vitro perifused interrenal gland preparation from the dogfish Scyliorhinus canicula was used to study production of quantitatively the major corticosteroid 1 alpha-hydroxycorticosterone (1 alpha-OH-B), measured by radioimmunoassay. Basal secretory rates were 877.1 +/- 145 (S.E.M.) fmol/mg per 15 min (n ...

journal_title：Journal of molecular endocrinology

authors： O'Toole LB,Armour KJ,Decourt C,Hazon N,Lahlou B,Henderson IW

更新日期：1990-08-01 00:00:00

abstract：:Leptin (Lep), an adipose-derived hormone, exerts very important functions in the body mainly on energy storage and availability. The physiological effects of Lep controlling the body weight and suppressing appetite are mediated by the long form of Lep receptor in the hypothalamus. Lep receptor activates several downst...

journal_title：Journal of molecular endocrinology

authors： Folch J,Pedrós I,Patraca I,Sureda F,Junyent F,Beas-Zarate C,Verdaguer E,Pallàs M,Auladell C,Camins A

更新日期：2012-10-10 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid hormone receptor superfamily and is activated by a variety of fibrate hypolipidaemic drugs and non-genotoxic rodent hepatocarcinogens that are collectively termed peroxisome proliferators. A key marker of peroxisome proliferator action is...

journal_title：Journal of molecular endocrinology

authors： Issemann I,Prince RA,Tugwood JD,Green S

更新日期：1993-08-01 00:00:00

abstract：:Sucrose density gradient purified plasma membranes isolated from brown adipose tissue of cold-acclimated hamsters (4-10 weeks at 0-4 degreesC) were analysed for the content of the short (GsalphaS) and long (GsalphaL) variants of Gsalpha protein (the alpha subunit of the stimulatory G protein) and compared with the mem...

journal_title：Journal of molecular endocrinology

authors： Bourová L,Novotn J,Svoboda P

更新日期：1999-02-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged during Transfection (RET) proto-oncogene plays a key role in the development of MTC. How...

journal_title：Journal of molecular endocrinology

authors： Cerrato A,De Falco V,Santoro M

更新日期：2009-10-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell origin. The majority of these tumors occur sporadically while ~20% manifest within the context of hereditary syndromes. Germline MEN1 mutations cause a syndrome with ...

journal_title：Journal of molecular endocrinology

authors： Lee ME,Tepede AA,Mandl A,Weinstein LS,Del Rivero J,Agarwal SK,Blau JE

更新日期：2020-08-01 00:00:00

abstract：:Expression of the rat alpha 2u-globulin gene family is regulated in the adult male liver by a number of hormones, including growth hormone, thyroid hormone and several steroids. Upon injection into ovariectomized females, estrogens first induce alpha 2u-globulin expression and then suppress this gene after several day...

journal_title：Journal of molecular endocrinology

authors： Wang KS,Hodgetts RB,Addison WR

更新日期：1998-02-01 00:00:00

abstract：:Critical to an understanding of the control of 1,25-dihydroxyvitamin D (1,25D) activity is a molecular appreciation of the regulation of three genes, 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1), 25-hydroxyvitamin D-24-hydroxylase (CYP24) and vitamin D receptor (VDR). We now report the sensitivity, reproducibility...

journal_title：Journal of molecular endocrinology

authors： Anderson PH,O'Loughlin PD,May BK,Morris HA

更新日期：2003-08-01 00:00:00

abstract：:The main regulators of aldosterone secretion in adrenal gland zona glomerulosa (ZG) cells are the hormones angiotensin II (Ang II) and adrenocorticotrophin (ACTH) and small increases in the extracellular potassium (K(+)) concentration. The action of these agonists is mediated by different signalling systems - ACTH is ...

journal_title：Journal of molecular endocrinology

authors： Foster RH

更新日期：2004-06-01 00:00:00

abstract：:Localization of inhibin/activin subunit mRNAs within the macaque ovary from the immediate pre-ovulatory period of the menstrual cycle, when serum immunoreactive inhibin begins to rise, to day 9 of the luteal phase, when serum inhibin concentrations are maximal, was investigated using in-situ hybridization. Ovaries wer...

journal_title：Journal of molecular endocrinology

authors： Fraser HM,Lunn SF,Cowen GM,Saunders PT

更新日期：1993-06-01 00:00:00