Differential effects of pancuronium on masseter and adductor pollicis muscles in humans.

Abstract:

:The sensitivity of the masseter, one of the muscles of the upper airway, to pancuronium was measured in ten adults undergoing elective surgery and compared with that of the adductor pollicis. During thiopental-nitrous oxide-enflurane (end-tidal concentration less than 0.25%) anesthesia, supramaximal nerve stimulation was applied to the ulnar nerve at the elbow and to the nerve to the masseter, at a point inferior to the zygomatic arch, anterior to the mandibular condyle. Jaw closure was measured by a force transducer system attached to both an oral airway and a metal frame fixed to the operating table 10 cm caudad to the chin. Cumulative dose-response curves for pancuronium (initial dose = 0.02 mg/kg, incremental doses = 0.01 mg/kg) were determined. Control twitch tensions were (mean +/- SEM) 473 +/- 75 g at the masseter and 660 +/- 118 g at the adductor pollicis. The masseter was slightly more sensitive to pancuronium, the ED50 being 0.024 +/- 0.001 mg/kg compared with 0.028 +/- 0.001 mg/kg for the adductor pollicis (P less than 0.05). Corresponding values for the ED90 were 0.038 +/- 0.004 and 0.043 +/- 0.002 mg/kg, respectively (P less than 0.05). The time from injection of the first dose of pancuronium to maximum blockade was 3.2 +/- 0.2 min at the masseter and 3.8 +/- 0.2 min at the adductor pollicis (P less than 0.01). Following incremental doses, this time was 1.8 +/- 0.1 and 2.6 +/- 0.1 min, respectively (P less than 0.01). It is concluded that after injection of pancuronium, neuromuscular blockade is greater at the masseter and occurs sooner than at the adductor pollicis. Jaw relaxation can be achieved with relatively small doses of pancuronium. This suggests that return of adductor pollicis function may not imply complete masseter muscle recovery.

journal_name

Anesthesiology

journal_title

Anesthesiology

authors

Smith CE,Donati F,Bevan DR

doi

10.1097/00000542-198907000-00011

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

57-61

issue

1

eissn

0003-3022

issn

1528-1175

journal_volume

71

pub_type

杂志文章
  • Ethanol and contraction of venous smooth muscle.

    abstract::Low concentrations of ethanol (17 mM) inhibited development of spontaneous mechanical activity (vasomotion) in isolated rat portal veins. Low concentrations of ethanol potentiated, however, contractions induced by epinephrine, but not those induced by angiotensin or potassium. Higher concentrations of ethanol, such as...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197604000-00009

    authors: Edgarian H,Altura BM

    更新日期:1976-04-01 00:00:00

  • Comparison of 0.5% ropivacaine and 0.5% bupivacaine for epidural anesthesia in patients undergoing lower-extremity surgery.

    abstract::Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-199004000-00010

    authors: Brown DL,Carpenter RL,Thompson GE

    更新日期:1990-04-01 00:00:00

  • Halothane and isoflurane decrease alveolar epithelial fluid clearance in rats.

    abstract:BACKGROUND:Active sodium transport is the primary mechanism that drives alveolar fluid clearance. In the current study, the effects of exposure to halothane and isoflurane on alveolar fluid clearance in rats were evaluated. METHODS:Rats were exposed to either halothane (0.4% for 6 h or 2% for 2 h) or isoflurane (0.6% ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199803000-00027

    authors: Rezaiguia-Delclaux S,Jayr C,Luo DF,Saïdi NE,Meignan M,Duvaldestin P

    更新日期:1998-03-01 00:00:00

  • Is the pressure rate quotient a predictor or indicator of myocardial ischemia as measured by ST-segment changes in patients undergoing coronary artery bypass surgery?

    abstract::Perioperative myocardial ischemia is associated with an increased risk of perioperative myocardial infarction (PMI). Several attempts have been made to define intraoperative hemodynamic predictors of myocardial ischemia. In a canine preparation with coronary stenosis, a pressure rate quotient (PRQ = mean arterial pres...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199105000-00008

    authors: Gordon MA,Urban MK,O'Connor T,Barash PG

    更新日期:1991-05-01 00:00:00

  • Major histocompatibility complex haplotype is associated with postherpetic pain in mice.

    abstract:BACKGROUND:Postherpetic neuralgia is one of the major complications of herpes zoster caused by the reactivation of varicella-zoster virus and is characterized by severe pain. The authors previously showed the association of a human major histocompatibility complex (MHC) haplotype with postherpetic neuralgia. This study...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200605000-00024

    authors: Sato-Takeda M,Takasaki I,Takeda K,Sasaki A,Andoh T,Nojima H,Shiraki K,Kuraishi Y,Hanaoka K,Tokunaga K,Yabe T

    更新日期:2006-05-01 00:00:00

  • Hepatic oxygen supply during halothane or isoflurane anesthesia in guinea pigs.

    abstract::The present study was designed to determine changes in hepatic oxygen supply in guinea pigs during halothane or isoflurane anesthesia. Twenty-seven guinea pigs were randomly divided into three equal groups: control (no anesthesia) group, and animals anesthetized with halothane or isoflurane to decrease mean arterial p...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198711000-00014

    authors: Hursh D,Gelman S,Bradley EL Jr

    更新日期:1987-11-01 00:00:00

  • Obesity decreases perioperative tissue oxygenation.

    abstract:BACKGROUND:Obesity is an important risk factor for surgical site infections. The incidence of surgical wound infections is directly related to tissue perfusion and oxygenation. Fat tissue mass expands without a concomitant increase in blood flow per cell, which might result in a relative hypoperfusion with decreased ti...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200402000-00015

    authors: Kabon B,Nagele A,Reddy D,Eagon C,Fleshman JW,Sessler DI,Kurz A

    更新日期:2004-02-01 00:00:00

  • Inhibition by ether of glucose-stimulated insulin secretion in isolated pieces of rat pancreas.

    abstract::Addition of glucose (16.7 mM) to isolated pieces of rat pancreas increased insulin secretion 5.4-fold over basal secretion rates. Ether at 1, 1.5 and 2 MAC inhibited this insulinogenic effect of glucose in a dose-related manner by 5, 18 (P less than 0.01) and 29 (P less than 0.01) per cent, respectively. ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197907000-00007

    authors: Gingerich RL,Paradise RR,Wright PH

    更新日期:1979-07-01 00:00:00

  • Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats.

    abstract::Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198203000-00009

    authors: Baden JM,Rice SA,Mazze RI

    更新日期:1982-03-01 00:00:00

  • Serious complications related to regional anesthesia: results of a prospective survey in France.

    abstract:BACKGROUND:Serious complications related to regional anesthesia have previously been described primarily in case reports and retrospective surveys. The authors prospectively evaluated a multicenter series of regional anesthetics, using preplanned criteria to measure the incidence and characteristics of associated serio...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199709000-00005

    authors: Auroy Y,Narchi P,Messiah A,Litt L,Rouvier B,Samii K

    更新日期:1997-09-01 00:00:00

  • Anesthetic-induced improvement of the inflammatory response to one-lung ventilation.

    abstract:BACKGROUND:Although one-lung ventilation (OLV) has become an established procedure during thoracic surgery, sparse data exist about inflammatory alterations in the deflated, reventilated lung. The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess p...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0b013e3181a10731

    authors: De Conno E,Steurer MP,Wittlinger M,Zalunardo MP,Weder W,Schneiter D,Schimmer RC,Klaghofer R,Neff TA,Schmid ER,Spahn DR,Z'graggen BR,Urner M,Beck-Schimmer B

    更新日期:2009-06-01 00:00:00

  • Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy.

    abstract:BACKGROUND:Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species. Currently, there are no other studies regarding the direct effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on reactive oxygen spe...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e318182a903

    authors: Kobayashi K,Yoshino F,Takahashi SS,Todoki K,Maehata Y,Komatsu T,Yoshida K,Lee MC

    更新日期:2008-09-01 00:00:00

  • Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices.

    abstract:BACKGROUND:Exogenous pyruvate and ethyl pyruvate (EP), the key ingredient in a new Ringer's solution in clinical trials, are antioxidants as well as metabolic substrates. In vivo studies show both to be protective in oxidative stress, with EP being better. The authors used an acute rat brain slice preparation to compar...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/01.anes.0000281898.01966.1e

    authors: Zeng J,Liu J,Yang GY,Kelly MJ,James TL,Litt L

    更新日期:2007-10-01 00:00:00

  • Bilateral suprazygomatic maxillary nerve block for cleft palate repair in children: a prospective, randomized, double-blind study versus placebo.

    abstract:BACKGROUND:The authors investigated the efficacy of bilateral suprazygomatic maxillary nerve block (SMB) for postoperative pain relief in infants undergoing cleft palate repair. METHODS:In this prospective, double-blind, single-site, randomized, and parallel-arm controlled trial, 60 children were assigned to undergo b...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0000000000000171

    authors: Chiono J,Raux O,Bringuier S,Sola C,Bigorre M,Capdevila X,Dadure C

    更新日期:2014-06-01 00:00:00

  • Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia.

    abstract:BACKGROUND:Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene (677C>T, 1298A>C) cause elevated plasma homocysteine concentrations and have been linked to fatal outcomes after nitrous oxide anesthesia. This study tested the hypothesis that patients with common MTHFR 677C>T or 1298A>C mutations develop hig...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e318178820b

    authors: Nagele P,Zeugswetter B,Wiener C,Burger H,Hüpfl M,Mittlböck M,Födinger M

    更新日期:2008-07-01 00:00:00

  • Electroacupuncture prophylaxis of postoperative nausea and vomiting following pediatric tonsillectomy with or without adenoidectomy.

    abstract:BACKGROUND:Electrical stimulation of acupuncture point P6 reduces the incidence of postoperative nausea or vomiting (PONV) in adult patients. However, acupressure, laser stimulation of P6, and acupuncture during anesthesia have not been effective for reducing PONV in the pediatric population. The authors studied the ef...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200202000-00013

    authors: Rusy LM,Hoffman GM,Weisman SJ

    更新日期:2002-02-01 00:00:00

  • Interaction of anesthesia, beta-receptor blockade, and blood loss in dogs with induced myocardial infarction.

    abstract::The cardiovascular effects of halothane-nitrous oxide anesthesia, and beta-receptor blockade with either propranolol or practolol, were studied in 15 dogs in which severe myocardial infarction had been induced ten days earlier. The hemodynamic responses to blood loss amounting to 25 per cent of estimated blood volume,...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197609000-00015

    authors: Prys-Roberts C,Roberts JG,Foëx P,Clarke TN,Bennett MJ,Ryder WA

    更新日期:1976-09-01 00:00:00

  • Brain Dynamics and Temporal Summation of Pain Predicts Neuropathic Pain Relief from Ketamine Infusion.

    abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception. Ketamine infusions can produce significant relief of neuropathic pain, but the treatment is resource i...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000002417

    authors: Bosma RL,Cheng JC,Rogachov A,Kim JA,Hemington KS,Osborne NR,Venkat Raghavan L,Bhatia A,Davis KD

    更新日期:2018-11-01 00:00:00

  • Arterial tonometry for noninvasive, continuous blood pressure monitoring during anesthesia.

    abstract::Arterial tonometry is a technique used to measure arterial blood pressure noninvasively. The authors developed a new tonometer system containing an array of 15 piezoresistive pressure transducers, a mechanical positioning system, signal conditioning and multiplexing electronics, and a display and control console. The ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199108000-00023

    authors: Kemmotsu O,Ueda M,Otsuka H,Yamamura T,Winter DC,Eckerle JS

    更新日期:1991-08-01 00:00:00

  • Effects of halothane and isoflurane on beta-adrenoceptor-mediated responses in the vascular smooth muscle of rat aorta.

    abstract:BACKGROUND:Although previous studies have proposed that anesthetics may influence signal transduction systems, their effects on the beta-adrenoceptor-mediated system have not been fully characterized in vascular smooth muscle. The aim of this study was to determine how halothane and isoflurane affect beta-adrenoceptor-...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199811000-00022

    authors: Tanaka S,Tsuchida H

    更新日期:1998-11-01 00:00:00

  • Respiratory, laryngeal, and tracheal responses to nasal insufflation of volatile anesthetics in anesthetized humans.

    abstract::In order to determine whether or not irritation of the nasal passage with commonly used volatile anesthetics can elicit airway reflexes, we investigated respiratory, laryngeal, and tracheal responses to nasal insufflation of three volatile anesthetics (enflurane, isoflurane, and halothane) in 13 patients anesthetized ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199109000-00010

    authors: Nishino T,Tanaka A,Ishikawa T,Hiraga K

    更新日期:1991-09-01 00:00:00

  • Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living.

    abstract:BACKGROUND:Postoperative delirium is one of the most common complications in the elderly surgical population. However, its long-term outcomes remain largely to be determined. Therefore a prospective cohort study was conducted to determine the association between postoperative delirium and long-term decline in activitie...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000002849

    authors: Shi Z,Mei X,Li C,Chen Y,Zheng H,Wu Y,Zheng H,Liu L,Marcantonio ER,Xie Z,Shen Y

    更新日期:2019-09-01 00:00:00

  • Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli.

    abstract:BACKGROUND:Dynorphin A in the spinal cord is considered to contribute to nociceptive stimuli. However, it has not yet been determined whether activation of the spinal dynorphinergic system under nociceptive stimuli plays a role in direct acceleration of the ascending nociceptive pathway. In this study, the authors inve...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e3181ca31d9

    authors: Taketa Y,Niikura K,Kobayashi Y,Furuya M,Shimizu T,Narita M,Imai S,Kuzumaki N,Maitani Y,Yamazaki M,Inada E,Iseki M,Suzuki T,Narita M

    更新日期:2010-02-01 00:00:00

  • Treatment of air embolism with a special pulmonary artery catheter introducer sheath in sitting dogs.

    abstract::The treatment of venous air embolism by aspiration from central venous catheters is well established. However, some anesthesiologists prefer to use a pulmonary artery catheter to monitor patients undergoing a neurosurgical procedure in the sitting position. While offering certain advantages, pulmonary artery catheters...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198801000-00017

    authors: Bowdle TA,Artru AA

    更新日期:1988-01-01 00:00:00

  • Relationship between anesthetic procedure and contact of anesthesia personnel with patient body fluids.

    abstract::We recorded the frequency with which anesthesia personnel came in contact with patient body fluids in order to provide an empirical basis for the recommendation of relevant precautions. Anesthesia personnel completed a questionnaire when performing a range of standardized procedures. The rate of contact with blood was...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199010000-00006

    authors: Kristensen MS,Sloth E,Jensen TK

    更新日期:1990-10-01 00:00:00

  • Effect of direct fetal opioid analgesia on fetal hormonal and hemodynamic stress response to intrauterine needling.

    abstract:BACKGROUND:Whether the fetus can experience pain remains controversial. During the last half of pregnancy, the neuroanatomic connections for nociception are in place, and the human fetus mounts sizable stress responses to physical insults. Analgesia has been recommended for intrauterine procedures or late termination, ...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200110000-00008

    authors: Fisk NM,Gitau R,Teixeira JM,Giannakoulopoulos X,Cameron AD,Glover VA

    更新日期:2001-10-01 00:00:00

  • Functional studies of RYR1 mutations in the skeletal muscle ryanodine receptor using human RYR1 complementary DNA.

    abstract:BACKGROUND:Malignant hyperthermia is associated with mutations within the gene encoding the skeletal muscle ryanodine receptor, the calcium channel that releases Ca from sarcoplasmic reticulum stores triggering muscle contraction, and other metabolic activities. More than 200 variants have been identified in the ryanod...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e3181d69283

    authors: Sato K,Pollock N,Stowell KM

    更新日期:2010-06-01 00:00:00

  • Spinal nitric oxide contributes to the analgesic effect of intrathecal [d-pen2,d-pen5]-enkephalin in normal and diabetic rats.

    abstract:BACKGROUND:Spinal nitric oxide (NO) is important for the analgesic actions of morphine and cholinergic agents. Its role in the analgesic effect of delta-opioid receptor agonists is not known. In the present study, the authors determined the role of spinal endogenous NO in the antinociceptive effect of intrathecal [D-Pe...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200301000-00033

    authors: Chen SR,Pan HL

    更新日期:2003-01-01 00:00:00

  • Insufflated halothane increases venous admixture less than nitroprusside in canine atelectasis.

    abstract::Although it generally is agreed that halothane is a pulmonary vasodilator, its effect on venous admixture and hypoxic pulmonary vasoconstriction are more controversial. The effects of 2.4% halothane on pulmonary vascular resistance and venous admixture were investigated in an isolated canine lobe made atelectatic. Hal...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199208000-00013

    authors: Johnson D,Hurst T,Mayers I

    更新日期:1992-08-01 00:00:00

  • Cumulative duration of "triple low" state of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia is not associated with increased mortality.

    abstract:BACKGROUND:Mortality after noncardiac surgery has been associated with the "triple low state," a combination of low mean arterial blood pressure (<75 mmHg), low bispectral index (<45), and low minimum alveolar concentration of volatile anesthesia (<0.70). The authors set out to determine whether duration of a triple lo...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000281

    authors: Kertai MD,White WD,Gan TJ

    更新日期:2014-07-01 00:00:00