Clinical value of octamer-binding transcription factor 4 as a prognostic marker in patients with digestive system cancers: A systematic review and meta-analysis.

Abstract:

BACKGROUND AND AIM:The role of octamer-binding transcription factor 4 (Oct4) has been implicated in the clinical prognosis of various kinds of digestive system cancers, but the results remain controversial. The purpose of this meta-analysis is to assess the potential role of Oct4 as a prognostic marker in digestive system tumors. METHODS:Relevant articles were retrieved from Pubmed, Web of Science, and Cochrane Library up to July 2016. The software Stata 12.0 was used to analyze the outcomes, including overall survival (OS), disease-free survival, recurrence-free survival, and clinicopathological characteristics. RESULTS:A total of 13 eligible studies with 1538 patients were included. Elevated Oct4 expression was significantly associated with poor OS (pooled hazard ratio [HR] = 2.183, 95% confidence interval [CI]: 1.824-2.612), disease-free survival (pooled HR = 1.973, 95% CI: 1.538-2.532), and recurrence-free survival (pooled HR = 2.209, 95% CI: 1.461-3.338) of digestive system malignancies. Subgroup analyses showed that cancer type, sample size, study quality, and laboratory detection method did not alter the significant prognostic value of Oct4. Additionally, Oct4 expression was found to be an independent predictive factor for OS (HR = 2.068, 95% CI: 1.633-2.619). No significant association was found between Oct4 and clinicopathological features of digestive system malignancies. CONCLUSION:This study provided evidence of Oct4 and/or its closely related homolog protein as a predictive factor for patients with digestive system cancers. More large-scale clinical studies on the prognostic value of Oct4 are warranted.

authors

Chen Z,Zhang L,Zhu Q,Wang X,Wu J,Wang X

doi

10.1111/jgh.13624

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

567-576

issue

3

eissn

0815-9319

issn

1440-1746

journal_volume

32

pub_type

杂志文章,meta分析
  • Hepatic ischemia reperfusion injury: Contemporary perspectives on pathogenic mechanisms and basis for hepatoprotection-the good, bad and deadly.

    abstract::Hepatic ischemia reperfusion (IR) injury is an important clinical problem complicating liver surgery and transplantation. The pathogenesis underlying reperfusion injury after warm ischemia is complex, encompassing a multitude of different cell types and signalling mechanisms innate and/or mobilized to the liver. Since...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06584.x

    authors: Teoh NC

    更新日期:2011-01-01 00:00:00

  • Magnetic resonance enterocolonography in detecting erosion and redness in intestinal mucosa of patients with Crohn's disease.

    abstract:BACKGROUND AND AIM:In Crohn's disease (CD), assessment of disease activity and extension is important for clinical management. Endoscopy is the most reliable tool for evaluating disease activity in these patients and it distinguishes between lesions based on ulcer, erosion, and redness. Magnetic resonance imaging (MRI)...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12851

    authors: Sato H,Tamura C,Narimatsu K,Shimizu M,Takajyo T,Yamashita M,Inoue Y,Ozaki H,Furuhashi H,Maruta K,Yasutake Y,Yoshikawa K,Watanabe C,Komoto S,Tomita K,Nagao S,Miura S,Shinmoto H,Hokari R

    更新日期:2015-04-01 00:00:00

  • Incidence and risk factors of Pneumocystis jirovecii pneumonia in Korean patients with inflammatory bowel disease.

    abstract:BACKGROUND AND AIM:Little is known whether routine prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is needed in patients with inflammatory bowel disease (IBD) on immunosuppression, especially in Asian populations. We, therefore, sought to investigate the incidence and risk factors of PJP in patients with IBD...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14832

    authors: Nam K,Park SH,Lee J,Jo S,Kim SO,Noh S,Park JC,Kim JY,Kim J,Ham NS,Oh EH,Song EM,Hwang SW,Yang DH,Ye BD,Byeon JS,Myung SJ,Yang SK

    更新日期:2020-02-01 00:00:00

  • Efficacy of hypothermic perfusion using University of Wisconsin solution in extended hepatectomy with hepatic inflow occlusion in a canine model.

    abstract::This study was designed to elucidate the efficacy of University of Wisconsin (UW) solution for preventing liver injury, when used as a hypothermic perfusate infused into the systemic circulation during extended hepatectomy with hepatic inflow occlusion. Adult mongrel dogs (9.5-17.5 kg, n = 14) were subjected to 75% he...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1998.tb00733.x

    authors: Ohya T,Ohwada S,Kawashima Y,Tanahashi Y,Takahashi T,Ichikawa H,Tomizawa N,Morishita Y

    更新日期:1998-08-01 00:00:00

  • Nationwide survey of specialist knowledge on current standard of care (Peg-IFN/RBV) and barriers of care in chronic hepatitis C patients in China.

    abstract:BACKGROUND AND AIM:Chronic hepatitis C virus (HCV) infection is the leading cause of liver diseases including cirrhosis and hepatocellular carcinoma. In China, it is a major national health problem that demands nationwide coordinated emphasis on prevention and treatment. To inform these initiatives, a nationwide survey...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13399

    authors: Wei L,Li J,Yang X,Wang G,Feng B,Hou J,Duan Z,Jia J,Ren H,Niu J,Chen X,Wang FS,Shang J,Bo Q,Li R,Liu Y,Zhuang H

    更新日期:2016-12-01 00:00:00

  • Post-infectious irritable bowel syndrome in patients with Shigella infection.

    abstract:BACKGROUND AND AIMS:Bacterial gastroenteritis has been known as a risk factor of irritable bowel syndrome (IBS). Several risk factors of post-infectious IBS (PI-IBS) have been documented. The aims of this study were to verify the role of bacterial gastroenteritis in the development of IBS and the risk factors for the d...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.03574.x

    authors: Ji S,Park H,Lee D,Song YK,Choi JP,Lee SI

    更新日期:2005-03-01 00:00:00

  • Association between anomalous pancreaticobiliary ductal union and adenomyomatosis of the gall-bladder.

    abstract::A frequent association of biliary tract carcinoma and anomalous pancreaticobiliary ductal union (APBD) is well recognized, especially gall-bladder carcinoma in undilated type APBD. However, little is known about the presence and incidence of adenomyomatosis (AMT) of the gall-bladder, a presumed premalignant lesion, in...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1998.tb00634.x

    authors: Tanno S,Obara T,Maguchi H,Fujii T,Mizukami Y,Shudo R,Takahashi K,Nishino N,Arisato S,Ura H,Kohgo Y

    更新日期:1998-02-01 00:00:00

  • Effect of Helicobacter pylori eradication on gastroesophageal function.

    abstract:BACKGROUND:To elucidate the cause of possible occurrence of reflux esophagitis after Helicobacter pylori eradication, gastric and esophageal function among H. pylori infected Japanese patients were evaluated both before and after eradication therapy. METHODS:Nine H. pylori-positive patients were studied before and 6 m...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2003.03301.x

    authors: Tanaka I,Tatsumi Y,Kodama T,Kato K,Fujita S,Mitsufuji S,Kashima K

    更新日期:2004-03-01 00:00:00

  • Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition.

    abstract::The Korean College of Helicobacter and Upper Gastrointestinal Research first developed guidelines for the diagnosis and treatment of Helicobacter pylori (H. pylori) infection in 1998, and revised guidelines were proposed in 2009 by the same group. Although the revised guidelines were based on a comprehensive review of...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1111/jgh.12607

    authors: Kim SG,Jung HK,Lee HL,Jang JY,Lee H,Kim CG,Shin WG,Shin ES,Lee YC,Korean College of Helicobacter and Upper Gastrointestinal Research.

    更新日期:2014-01-01 00:00:00

  • Ledipasvir/sofosbuvir fixed-dose combination tablet in Taiwanese patients with chronic genotype 1 hepatitis C virus.

    abstract:BACKGROUND AND AIM:Pegylated-interferon-alpha plus ribavirin is the current standard-of-care regimen for treating chronic hepatitis C virus (HCV) infection in Taiwan; however, interferon-based regimens can be poorly tolerated. The interferon-free, two-drug, fixed-dose combination tablet ledipasvir/sofosbuvir is approve...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgh.13305

    authors: Chuang WL,Chien RN,Peng CY,Chang TT,Lo GH,Sheen IS,Wang HY,Chen JJ,Yang JC,Knox SJ,Gao B,Garrison KL,Mo H,Pang PS,Hsu YC,Hu TH,Chu CJ,Kao JH

    更新日期:2016-07-01 00:00:00

  • Hypothermia induced by adenosine 5'-monophosphate attenuates injury in an L-arginine-induced acute pancreatitis rat model.

    abstract:BACKGROUND AND AIM:This study sought to investigate the effects of hypothermia induced by adenosine 5'-monophosphate (5'-AMP) on L-arginine (L-Arg)-induced acute pancreatitis in rats. METHODS:The rats were divided into four groups: the control group, the acute pancreatitis group, the 5'-AMP pretreatment group, and the...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12448

    authors: Wang Y,Guo W,Li Y,Pan X,Lv W,Cui L,Li C,Wang Y,Yan S,Zhang J,Liu B

    更新日期:2014-04-01 00:00:00

  • Safety and immunogenicity of hepatitis A vaccine in healthy adult volunteers.

    abstract::The immunogenicity and adverse reaction of an inactivated hepatitis A (HA) vaccine were investigated. Sixty healthy adult volunteers who lacked antibody to HA virus (anti-HAV) received three doses of vaccine containing 720 enzyme-linked immunosorbent assay (ELISA) units (EL.U) according to a 0, 1 and 6 month schedule....

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1993.tb01524.x

    authors: Horng YC,Chang MH,Lee CY,Safary A,Andre FE,Chen DS

    更新日期:1993-07-01 00:00:00

  • Combination and newer therapies for chronic hepatitis B.

    abstract::Worldwide the need for effective therapy for chronic hepatitis B is similar to that for chronic hepatitis C. Current licensed treatment for chronic hepatitis B (interferon (IFN)-alpha, lamivudine) does not significantly alter the natural history of the disease because the frequency of sustained response is too low; ho...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.17.s3.24.x

    authors: Schalm SW,De Man RA,Janssen HL

    更新日期:2002-12-01 00:00:00

  • Efficacy and safety of low-pressured and short-time dilation in endoscopic papillary balloon dilation for bile duct stone removal.

    abstract:BACKGROUND AND AIM:Endoscopic papillary balloon dilation (EPBD) has been advocated as an alternative therapy to endoscopic sphincterotomy for bile duct stones. However, studies have shown that EPBD may increase the risk for pancreatitis. Pancreatitis after EPBD is believed to be related to papillary damage after balloo...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.05267.x

    authors: Tsujino T,Kawabe T,Isayama H,Sasaki T,Kogure H,Togawa O,Arizumi T,Ito Y,Matsubara S,Yamamoto N,Nakai Y,Sasahira N,Hirano K,Toda N,Komatsu Y,Tada M,Yoshida H,Omata M

    更新日期:2008-06-01 00:00:00

  • Predicting the efficacy of proton pump inhibitors in patients with non-erosive reflux disease before therapy using dual-channel 24-h esophageal pH monitoring.

    abstract:BACKGROUND AND AIM:We aimed to determine whether reflux- and symptom-related parameters can predict the efficacy of proton pump inhibitors (PPI) in non-erosive reflux disease (NERD). METHODS:Twenty-seven NERD patients who had experienced heartburn more than once a week within the previous month were enrolled. Intraeso...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1440-1746.2011.06975.x

    authors: Shimatani T,Sugimoto M,Nishino M,Adachi K,Furuta K,Ito M,Kurosawa S,Manabe N,Mannen K,Hongo M,Chiba T,Kinoshita Y,Acid-Related Symptom Research (ARS) Group.

    更新日期:2012-05-01 00:00:00

  • Long-term follow up of a randomized, controlled trial on prophylactic sclerotherapy of small oesophageal varices in liver cirrhosis.

    abstract:BACKGROUND:In order to evaluate the prophylactic impact of sclerotherapy of small varices in patients with cirrhosis and no endoscopic signs suggesting risk of haemorrhage, a randomized clinical trial was performed. METHODS:Seventy-one hospitalized patients met the inclusion criteria of diagnosis of cirrhosis with no ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1440-1746.1999.01799.x

    authors: Strauss E,Ribeiro MF,Albano A,Honain NZ,Maffei RA Jr,Caly WR

    更新日期:1999-03-01 00:00:00

  • Hepatic microsomal protein and cytochrome P-450 in BALB/c mice infected with Leishmania.

    abstract::The effects of infection of mice with Leishmania major on liver microsomal protein and cytochrome P-450 were examined. The levels of hepatic microsomal protein and cytochrome P-450 were monitored at 6, 7, 9 and 12 weeks post-infection. The results indicated that the amount of hepatic microsomal protein and cytochrome ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1989.tb00855.x

    authors: al-Mofleh IA,al-Khuwaitir SA,Mahmoud AA,Kyegombe DB,al-Tuwaijri AS

    更新日期:1989-11-01 00:00:00

  • Identification of genes with universally upregulated or downregulated expressions in colorectal cancer.

    abstract:BACKGROUND AND AIM:Differentially expressed (DE) genes detected at the population-level through case-control comparison provide no information on the dysregulation frequencies of DE genes in a cancer. In this work, we aimed to identify the genes with universally upregulated or downregulated expressions in colorectal ca...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14529

    authors: Song K,Su W,Liu Y,Zhang J,Liang Q,Li N,Guan Q,He J,Bai X,Zhao W,Guo Z

    更新日期:2019-05-01 00:00:00

  • Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan.

    abstract::It was recently reported that mutations in the precore and core promoter region of hepatitis B virus (HBV) are associated with fulminant hepatitis. The aim of this study was to investigate the association of mutations in the precore and core promoter region of HBV with fulminant and severe acute hepatitis. We studied ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1998.tb00588.x

    authors: Aritomi T,Yatsuhashi H,Fujino T,Yamasaki K,Inoue O,Koga M,Kato Y,Yano M

    更新日期:1998-11-01 00:00:00

  • Hyposplenism in alcoholic cirrhosis, facts or artifacts? A comparative analysis with non-alcoholic cirrhosis and extrahepatic portal venous obstruction.

    abstract:BACKGROUND AND AIMS:Hyposplenism has been described in patients with alcoholic cirrhosis (AC). However, no data are available regarding hyposplenism in patients with non-alcoholic cirrhosis (NAC) and other forms of portal hypertension such as extrahepatic portal venous obstruction (EHPVO). The aim is to study the splen...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2001.02567.x

    authors: Satapathy SK,Narayan S,Varma N,Dhiman RK,Varma S,Chawla Y

    更新日期:2001-09-01 00:00:00

  • Larger biopsies evaluation of transient elastography for detecting advanced fibrosis in patients with compensated chronic hepatitis B.

    abstract:BACKGROUND AND AIM:Although larger biopsies sample had been recommended for the study of non-invasive liver fibrosis assessment, few studies with larger biopsies for transient elastography (TE) detecting liver fibrosis had been reported. The present study tries to re-evaluate the performance of TE for detecting advance...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2012.07122.x

    authors: Chen YP,Liang XE,Zhang Q,Peng J,Zhu YF,Wen WQ,Hou JL

    更新日期:2012-07-01 00:00:00

  • The role of solid debris in endoscopic ultrasound-guided drainage of walled-off necrosis: A large cohort study.

    abstract:BACKGROUND AND AIM:The effect of solid debris on walled-off necrosis (WON) drainage remains unknown. Our study evaluated the role of solid debris in endoscopic ultrasound (EUS)-guided drainage of WON compared lumen-apposing metal stent (LAMS) with double-pigtail plastic stent (DPPS). METHODS:We retrospectively evaluat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15086

    authors: Zhu H,Xie P,Wang Y,Jin Z,Li Z,Du Y

    更新日期:2020-05-04 00:00:00

  • Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection.

    abstract:BACKGROUNDS AND AIM:Clarithromycin (CAM)-resistant Helicobacter pylori sometimes offers serious problems with eradication by antibiotics. The aim of this study was to determine whether a probiotic can be an alternative therapy in CAM-resistant Hp infection. METHODS:The effects of Lactobacillus gasseri (strain OLL2716)...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.03102.x

    authors: Ushiyama A,Tanaka K,Aiba Y,Shiba T,Takagi A,Mine T,Koga Y

    更新日期:2003-08-01 00:00:00

  • Repeated stereotactic ablative radiotherapy using CyberKnife for patients with hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:This study aimed to evaluate the outcomes and toxicities of repeated stereotactic ablative radiotherapy (SABR) in hepatocellular carcinoma (HCC). METHODS:Fourteen HCC patients with local recurrence (18 lesions) after liver SABR received repeated radiotherapy with SABR using CyberKnife. No patients e...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12659

    authors: Lo CH,Huang WY,Lin KT,Lin MJ,Lin TP,Jen YM

    更新日期:2014-11-01 00:00:00

  • Hepatocellular carcinoma in an Australian tertiary referral hospital 1975-2002: change in epidemiology and clinical presentation.

    abstract:AIM:We compared the epidemiology and clinical features of hepatocellular carcinoma (HCC) cases diagnosed between 1975 and 2002. METHODS:Retrospective and prospective analysis was performed of HCC cases diagnosed at The Alfred during the time periods 1975-1983 and 1995-2002. Demographic, epidemiological, clinical and l...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04459.x

    authors: Roberts SK,Kemp W

    更新日期:2007-02-01 00:00:00

  • Age-related analysis of functional outcome and quality of life after restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis.

    abstract:BACKGROUND:The aim of the present study was to evaluate the influence of a younger age at the time of ileal pouch-anal anastomosis (IPAA) on functional outcome and quality of life in patients with familial adenomatous polyposis (FAP). METHOD:A total of 105 patients with FAP who had undergone IPAA were retrieved from a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04870.x

    authors: Erkek AB,Church JM,Remzi FH

    更新日期:2007-05-01 00:00:00

  • Impact of molecular adsorbent recirculating system on renal recovery in type-1 hepatorenal syndrome patients with chronic liver failure.

    abstract:BACKGROUND AND AIM:Liver transplantation remains the best option for treating type-1 hepatorenal syndrome (HRS1). The aim of this retrospective study was to determine whether the molecular adsorbent recirculation system (MARS) can improve renal function in HRS1 patients. METHODS:Thirty-two patients with chronic liver ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12159

    authors: Lavayssière L,Kallab S,Cardeau-Desangles I,Nogier MB,Cointault O,Barange K,Muscari F,Rostaing L,Kamar N

    更新日期:2013-06-01 00:00:00

  • Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma.

    abstract:BACKGROUND:It has been reported that cathepsin E (CTSE) is a non-secretory and intracellular aspartic proteinase found in the superficial epithelial cells of the stomach and that it is also expressed in pancreatic ductal adenocarcinoma. We evaluated the diagnostic value of CTSE in the pancreatic juice in the diagnosis ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:

    authors: Uno K,Azuma T,Nakajima M,Yasuda K,Hayakumo T,Mukai H,Sakai T,Kawai K

    更新日期:2000-11-01 00:00:00

  • Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody.

    abstract:BACKGROUND:Microbial agents are a possible cause of ulcerative colitis. We have previously reported evidence of bacteria invading the colonic mucosa of patients with ulcerative colitis. We have isolated bacteria from inflamed colonic mucosa, examined the localization of the species in the mucosa, and assayed for serum ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2002.02834.x

    authors: Ohkusa T,Sato N,Ogihara T,Morita K,Ogawa M,Okayasu I

    更新日期:2002-08-01 00:00:00

  • Aging increases, and duodenal ulcer reduces the risk for intestinal metaplasia of the gastric corpus in Japanese patients with dyspepsia.

    abstract:BACKGROUND AND AIMS:The classification of gastritis by using the revised Sydney system suggests that there are two types of Helicobacter pylori-related gastritis. The aim of the present study was to examine the risk factors that might be involved in the presence of either atrophic gastritis or intestinal metaplasia of ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2001.02380.x

    authors: Tsukui T,Kashiwagi R,Sakane M,Tabata F,Akamatsu T,Wada K,Futagami S,Miyake K,Sueoka N,Hirakawa T,Kobayashi M,Fujimori T,Sakamoto C

    更新日期:2001-01-01 00:00:00