Abstract:
BACKGROUND AND AIM:The role of octamer-binding transcription factor 4 (Oct4) has been implicated in the clinical prognosis of various kinds of digestive system cancers, but the results remain controversial. The purpose of this meta-analysis is to assess the potential role of Oct4 as a prognostic marker in digestive system tumors. METHODS:Relevant articles were retrieved from Pubmed, Web of Science, and Cochrane Library up to July 2016. The software Stata 12.0 was used to analyze the outcomes, including overall survival (OS), disease-free survival, recurrence-free survival, and clinicopathological characteristics. RESULTS:A total of 13 eligible studies with 1538 patients were included. Elevated Oct4 expression was significantly associated with poor OS (pooled hazard ratio [HR] = 2.183, 95% confidence interval [CI]: 1.824-2.612), disease-free survival (pooled HR = 1.973, 95% CI: 1.538-2.532), and recurrence-free survival (pooled HR = 2.209, 95% CI: 1.461-3.338) of digestive system malignancies. Subgroup analyses showed that cancer type, sample size, study quality, and laboratory detection method did not alter the significant prognostic value of Oct4. Additionally, Oct4 expression was found to be an independent predictive factor for OS (HR = 2.068, 95% CI: 1.633-2.619). No significant association was found between Oct4 and clinicopathological features of digestive system malignancies. CONCLUSION:This study provided evidence of Oct4 and/or its closely related homolog protein as a predictive factor for patients with digestive system cancers. More large-scale clinical studies on the prognostic value of Oct4 are warranted.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Chen Z,Zhang L,Zhu Q,Wang X,Wu J,Wang Xdoi
10.1111/jgh.13624subject
Has Abstractpub_date
2017-03-01 00:00:00pages
567-576issue
3eissn
0815-9319issn
1440-1746journal_volume
32pub_type
杂志文章,meta分析abstract::Hepatic ischemia reperfusion (IR) injury is an important clinical problem complicating liver surgery and transplantation. The pathogenesis underlying reperfusion injury after warm ischemia is complex, encompassing a multitude of different cell types and signalling mechanisms innate and/or mobilized to the liver. Since...
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doi:10.1111/j.1440-1746.1998.tb00733.x
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doi:10.1111/j.1440-1746.2003.03301.x
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doi:10.1111/j.1440-1746.1993.tb01524.x
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doi:10.1111/j.1440-1746.1989.tb00855.x
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doi:10.1111/j.1440-1746.1998.tb00588.x
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journal_title:Journal of gastroenterology and hepatology
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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doi:10.1046/j.1440-1746.2002.02834.x
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pub_type: 杂志文章
doi:10.1046/j.1440-1746.2001.02380.x
更新日期:2001-01-01 00:00:00