Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection.

Abstract:

BACKGROUNDS AND AIM:Clarithromycin (CAM)-resistant Helicobacter pylori sometimes offers serious problems with eradication by antibiotics. The aim of this study was to determine whether a probiotic can be an alternative therapy in CAM-resistant Hp infection. METHODS:The effects of Lactobacillus gasseri (strain OLL2716) on the growth of CAM-susceptible and CAM-resistant H. pylori and interleukin (IL)-8 production provoked by these strains were examined by in vitro experiments. Moreover, mice were infected with these CAM-susceptible or CAM-resistant H. pylori, and were treated with CAM or L. gasseri. RESULTS:In vitro experiments demonstrated that L. gasseri inhibited the growth of H. pylori and suppressed H. pylori-associated IL-8 production. Such effects were noted in CAM-resistant and CAM-susceptible H. pylori. Similarly, in an in vivo model of H. pylori infection, H. pylori colonization was significantly decreased by L. gasseri. CONCLUSION:Therefore, L. gasseri was found to act as a probiotic in CAM-resistant H. pylori infection.

authors

Ushiyama A,Tanaka K,Aiba Y,Shiba T,Takagi A,Mine T,Koga Y

doi

10.1046/j.1440-1746.2003.03102.x

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

986-91

issue

8

eissn

0815-9319

issn

1440-1746

pii

3102

journal_volume

18

pub_type

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