ROS-dependent genotoxicity, cell cycle perturbations and apoptosis in mouse bone marrow cells exposed to formulated mixture of cypermethrin and chlorpyrifos.

abstract：:In order to establish the capacity of Mytilus spp. to form genotoxin-DNA adducts, a series of in vitro and in vivo studies were conducted in which tissue samples and animals were exposed to five model genotoxins. Following the in vitro characterization of the major adducts induced by the compounds, a series of in vivo...

journal_title：Mutagenesis

authors： Harvey JS,Parry JM

更新日期：1997-05-01 00:00:00

abstract：:In the present study we evaluated campthotecin (CPT)-induced chromosomal damage in human lymphocytes in the G0 phase of the cell cycle as revealed by the premature chromosome condensation technique. The results obtained here indicate that CPT was able to induce chromosome fragments in the G0 phase of the cell cycle of...

journal_title：Mutagenesis

authors： Mosesso P,Fonti E,Bassi L,Lorenti Garcia C,Palitti F

更新日期：1999-01-01 00:00:00

abstract：:The nucleoside analog zidovudine (3'-azido-3'-deoxythymidine, AZT), by itself or in combination with other anti- retroviral drugs, is used perinatally to prevent mother to child transmission of human immunodeficiency virus type 1. AZT is mutagenic in vitro and mutagenic and carcinogenic when administered to neonatal m...

journal_title：Mutagenesis

authors： Von Tungeln LS,Dobrovolsky VN,Bishop ME,Shaddock JG,Heflich RH,Beland FA

更新日期：2004-07-01 00:00:00

abstract：:Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of underst...

journal_title：Mutagenesis

authors： Creton S,Aardema MJ,Carmichael PL,Harvey JS,Martin FL,Newbold RF,O'Donovan MR,Pant K,Poth A,Sakai A,Sasaki K,Scott AD,Schechtman LM,Shen RR,Tanaka N,Yasaei H

更新日期：2012-01-01 00:00:00

abstract：:A relatively large, reproducible inter-individual variation was found in the ability of 17 human liver S9 samples to mediate the mutagenicity of 2-acetylaminofluorene (2AAF) in Salmonella typhimurium strain TA98. In an animal model, variation in metabolic activation of 2AAF did not appear to relate to the phenotype of...

journal_title：Mutagenesis

authors： Smith AJ,Chipman JK

更新日期：1988-07-01 00:00:00

abstract：:A substantial database on hprt mutant frequency in circulating T-cells derived from 153 normal humans was analysed to determine if any effect of alcohol consumption could be detected. Alcohol intake (as reported in a questionnaire completed at the time of the blood sample) ranged from 0 to 35+ units per week. Donors w...

journal_title：Mutagenesis

authors： Cole J,Green MH

更新日期：1995-09-01 00:00:00

abstract：:3 beta-Hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl) aminophenoxyacetate (NSC 294859) is a new modified steroidal alkylating agent. This compound was given by i.p. administration to mice bearing different types of tumour. It was found to exhibit good activity in L1210 and...

journal_title：Mutagenesis

authors： Tselepi MR,Demopoulos NA,Catsoulacos P

更新日期：1989-09-01 00:00:00

abstract：:The effects of deficiency in the DNA mismatch repair (MMR) protein Pms2 were investigated using the endogenous mouse Hprt and Tk genes as reporters of intragenic mutation and loss of heterozygosity (LOH). Pms2(-/-)Tk(+/-), Pms2(+/+)Tk(+/-), Pms2(+/-)Tk(+/-) and Pms2(-/-)Tk(-/-) mice were bred from Pms2(+/-)Tk(+/-) mic...

journal_title：Mutagenesis

authors： Dobrovolsky VN,McKinzie PB,Shaddock JG,Mittelstaedt RA,Heflich RH,Parsons BL

更新日期：2003-07-01 00:00:00

abstract：:Exposure to ambient air particles is associated with elevated levels of DNA strand breaks (SBs) and endonuclease III, formamidopyrimidine DNA glycosylase (FPG) and oxoguanine DNA glycosylase-sensitive sites in cell cultures, animals and humans. In both animals and cell cultures, increases in SB and in oxidatively dama...

journal_title：Mutagenesis

authors： Møller P,Hemmingsen JG,Jensen DM,Danielsen PH,Karottki DG,Jantzen K,Roursgaard M,Cao Y,Kermanizadeh A,Klingberg H,Christophersen DV,Hersoug LG,Loft S

更新日期：2015-01-01 00:00:00

abstract：:This study was a part of an international project sponsored by the Commission of the European Communities to evaluate the utility of certain bioassays including hexaploid wheat assay to identify potential aneugens. Ten suspect spindle poisons, i.e. colchicine (COL), cadmium chloride (CdCl2), chloral hydrate (CH), diaz...

journal_title：Mutagenesis

authors： Sandhu SS,Dhesi JS,Gill BS,Svendsgaard D

更新日期：1991-09-01 00:00:00

abstract：:ISIS 2302, a phosphorothioate oligodeoxynucleotide with antisense activity against human ICAM-1 mRNA, was evaluated in a battery of tests to assess genotoxic potential. There was no evidence of genotoxicity in three in vitro studies performed: (i) a bacterial reverse mutation test; (ii) a chromosomal aberration test i...

journal_title：Mutagenesis

authors： Henry SP,Monteith DK,Matson JE,Mathison BH,Loveday KS,Winegar RA,Matson JE,Lee PS,Riccio ES,Bakke JP,Levin AA

更新日期：2002-05-01 00:00:00

abstract：:We have shown previously that UVC irradiation of benzo[a]pyrene diol epoxide (BPDE)-adducted DNA (BPDE/UVC) induces an increase in mutation frequency in the supF gene greater than the calculated additive value derived from either treatment alone, with a greater absolute increase in the level of BPDE signature transver...

journal_title：Mutagenesis

authors： McLuckie KI,Gaskell M,Farmer PB,Martin EA,Jones GD,Routledge MN

更新日期：2004-03-01 00:00:00

abstract：:The repairability during G(1) of DNA lesions eliciting sister chromatid exchanges (SCE) induced by methylmethanesulfonate (MMS) and ethylmethanesulfonate (EMS) in BrdU-substituted and unsubstituted DNA strands was determined in murine salivary gland cells in vivo. The SCE frequency was determined after exposure to MMS...

journal_title：Mutagenesis

authors： González-Beltrán F,Morales-Ramírez P

更新日期：2003-01-01 00:00:00

abstract：:The clastogenic potential of sodium fluoride was determined both in vitro (using cultured human lymphocytes) and in vivo (using the rat bone-marrow micronucleus test). The incidence of chromosome aberrations in human lymphocyte cultures exposed to 20 or 40 micrograms/ml sodium fluoride (3 and 9% respectively) was sign...

journal_title：Mutagenesis

authors： Albanese R

更新日期：1987-11-01 00:00:00

abstract：:Recent studies suggest increased cancer risk in patients with type 2 diabetes mellitus (T2DM) compared with healthy individuals. The present study aims to assess whether T2DM is associated with increased genome instability and whether a healthy diet with natural foods can improve genome stability in peripheral blood l...

journal_title：Mutagenesis

authors： Müllner E,Brath H,Toferer D,Adrigan S,Bulla MT,Stieglmayer R,Wallner M,Marek R,Wagner KH

更新日期：2013-03-01 00:00:00

abstract：:Activation of the human bladder carcinogen 4-aminobiphenyl (ABP) and its N-hydroxy derivatives was investigated using lysates and subcellular enzyme preparations from cultured human uroepithelial cells (HUC). Mutagenic activation was determined using Salmonella typhimurium strains TA98; TA98/1,8-DNP6, a derivative def...

journal_title：Mutagenesis

authors： Hatcher JF,Rao KP,Swaminathan S

更新日期：1993-03-01 00:00:00

abstract：:CASE, an artificial intelligence structure-activity relational system, was used to predict the carcinogenicity of a group of chemicals currently being tested in rodent bioassays by the US National Toxicology Program. The 'learning set' for the CASE predictions consisted of the results of previous 252 rodent carcinogen...

journal_title：Mutagenesis

authors： Rosenkranz HS,Klopman G

更新日期：1990-09-01 00:00:00

abstract：:Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are mutagenic and carcinogenic environmental pollutants found in diesel exhaust and on urban air pollution particles. In the present study, human bronchial epithelial BEAS-2B cells were exposed to 2-nitrobenzanthrone (2-NBA) and 3-nitrobenzanthrone (3-NBA). DNA damag...

journal_title：Mutagenesis

authors： Oya E,Ovrevik J,Arlt VM,Nagy E,Phillips DH,Holme JA

更新日期：2011-11-01 00:00:00

abstract：:Among the tests used to determine the mutagenic potential of chemicals, the chromosomal aberrations and micronucleus assays play an important role. These tests score either chromosomal structural aberrations at metaphase or micronuclei at interphase. One of the hallmarks of apoptosis is DNA fragmentation into 50-300 k...

journal_title：Mutagenesis

authors： Meintières S,Biola A,Pallardy M,Marzin D

更新日期：2001-05-01 00:00:00

abstract：:The cytogenetic effects of mimosine, a naturally occurring plant amino acid known to arrest cell-cycle progression at the G1-S border in cultured cells, have been studied. It was found that mimosine inhibits the cell-cycle progression in a dose-dependent manner in primary and transformed Chinese hamster fibroblasts as...

journal_title：Mutagenesis

authors： Jha AN,Hande PM,Mullenders LH,Natarajan AT

更新日期：1995-09-01 00:00:00

abstract：:The importance of diet in DNA damage prevention is well established; however, the comparison of weight loss diets with different micronutrient and macronutrient profiles on genome stability in peripheral blood lymphocytes (PBLs) has not been studied. This study tested the hypothesis that genome stability in PBLs of ov...

journal_title：Mutagenesis

authors： Benassi-Evans B,Clifton PM,Noakes M,Keogh JB,Fenech M

更新日期：2009-05-01 00:00:00

abstract：:The effect of cerium oxide nanoparticle (CeNP) in plants has elicited substantial controversy. While some investigators have reported that CeNP possesses antioxidant properties, others observed CeNP to induce reactive oxygen species (ROS). In spite of considerable research carried out on the effects of CeNP in metazoa...

journal_title：Mutagenesis

authors： Sadhu A,Ghosh I,Moriyasu Y,Mukherjee A,Bandyopadhyay M

更新日期：2018-04-13 00:00:00

abstract：:Radiation-induced exchange aberrations are thought to arise as a consequence of misrejoining of free ends of DNA double strand breaks (dsbs). In quiescent mammalian cells this process of misrejoining is prevalently taken up by the non-homologous end joining (NHEJ) process. In order to investigate the role of glutathio...

journal_title：Mutagenesis

authors： Dutta A,Chakraborty A,Saha A,Ray S,Chatterjee A

更新日期：2005-09-01 00:00:00

abstract：:In Saccharomyces cerevisiae, disruption of genes by deletion allowed elucidation of the molecular mechanisms of a series of human diseases, such as in Wilson disease (WD). WD is a disorder of copper metabolism, due to inherited mutations in human copper-transporting ATPase (ATP7B). An orthologous gene is present in S....

journal_title：Mutagenesis

authors： da Silva CR,Almeida GS,Caldeira-de-Araújo A,Leitão AC,de Pádula M

更新日期：2016-01-01 00:00:00

abstract：:Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is an autosomal dominant disorder characterized by blepharophimosis, ptosis and epicanthus inversus. Based on the presence and absence of premature ovarian failure, two clinical types have been distinguished. Both types of BPES have been mapped to chromosome ...

journal_title：Mutagenesis

authors： Tang S,Wang X,Lin L,Sun Y,Wang Y,Yu H

更新日期：2006-01-01 00:00:00

abstract：:The adaptive response is a phenomenon by which cells exposed to low, non-cytotoxic doses of a genotoxicant become significantly resistant to a subsequent higher dose of the same or another genotoxic agent. Induction of the adaptive response has been mainly studied using ionizing radiation and alkylating agents as geno...

journal_title：Mutagenesis

authors： Oliveira NG,Rodrigues AS,Chaveca T,Rueff J

更新日期：1997-11-01 00:00:00

abstract：:Chemical carcinogenesis can be induced by genotoxic (GTX) or non-genotoxic (NGTX) carcinogens. GTX carcinogens have a well-described mode of action. However, the complex mechanisms by which NGTX carcinogens act are less clear and may result in conflicting results between species [e.g. Wy-14,643 (Wy)]. We hypothesise t...

journal_title：Mutagenesis

authors： Rieswijk L,Brauers KJ,Coonen ML,van Breda SG,Jennen DG,Kleinjans JC

更新日期：2015-11-01 00:00:00

abstract：:Nanoremediation of soil, ground and surface water using nanoscale zerovalent iron particles (nZVI) has facilitated their direct environmental exposure posing ecotoxicological concerns. Numerous studies elucidate their phytotoxicity in terms of growth and their fate within the plant system. However, their potential gen...

journal_title：Mutagenesis

authors： Ghosh I,Mukherjee A,Mukherjee A

更新日期：2017-05-01 00:00:00

abstract：:Urine samples from 26 cigarette smokers on a restricted diet were collected in the late afternoon. Urine extracts on XAD-2 resin were tested for mutagenicity in the microsuspension assay using Salmonella typhimurium strain TA98 in the presence of metabolizing and deconjugating enzymes. Levels of urinary nicotine plus ...

journal_title：Mutagenesis

authors： Granella M,Priante E,Nardini B,Bono R,Clonfero E

更新日期：1996-03-01 00:00:00

abstract：:Basic extracts isolated from lamb meat treated at various temperatures were tested for mutagenicity in Salmonella typhimurium strain TA98 in the presence of S9 mix. Samples of ground lamb patties were cooked for 10 min per side at 100, 150, 200, 250 and 300 degrees C. Low cooking temperatures resulted in products with...

journal_title：Mutagenesis

authors： Sflomos C,Papadopoulou R,Athanasiou K

更新日期：1989-05-01 00:00:00